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Molecular alterations in a patient with Turcot's syndrome.

Rochlitz CF, Heide I, de Kant E, Neubauer A, Schmidt CA, Neuhaus P, Huhn D, Herrmann R - Br. J. Cancer (1993)

Bottom Line: Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene.Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

View Article: PubMed Central - PubMed

Affiliation: Department Innere Medizin, Kantonsspital Basel.

ABSTRACT
Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

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Related in: MedlinePlus

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Molecular alterations in a patient with Turcot's syndrome.

Rochlitz CF, Heide I, de Kant E, Neubauer A, Schmidt CA, Neuhaus P, Huhn D, Herrmann R - Br. J. Cancer (1993)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1968408&req=5

Bottom Line: Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene.Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

View Article: PubMed Central - PubMed

Affiliation: Department Innere Medizin, Kantonsspital Basel.

ABSTRACT
Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

Show MeSH
Related in: MedlinePlus