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House dust mite control measures in the treatment of asthma.

Vallance G, McSharry C, Wood S, Thomson NC - Ther Clin Risk Manag (2006)

Bottom Line: Sensitization to the house dust mite (Dermataphagoides pteronyssinus) (HDM) is the most common risk factor associated with the development of asthma in adults and children.However, a recent multi-allergen reduction approach has suggested benefits may be achievable.HDM densities tend to be high in warm, humid conditions in the home, which may be modified by external factors, such as ventilation.

View Article: PubMed Central - PubMed

ABSTRACT
Sensitization to the house dust mite (Dermataphagoides pteronyssinus) (HDM) is the most common risk factor associated with the development of asthma in adults and children. The effectiveness of HDM control measures in the treatment of asthma is not yet proven. The strategies for control for avoidance depend on our understanding of the biology of the HDM. The evidence suggests a favorable effect of transferring allergic asthmatic children to naturally low dust mite environments, such as at altitude or in hospital, but little to suggest that this can be replicated in general practice by simple practical measures such as mattress covers. However, a recent multi-allergen reduction approach has suggested benefits may be achievable. HDM densities tend to be high in warm, humid conditions in the home, which may be modified by external factors, such as ventilation. However, ventilation control to reduce indoor humidity has had inconsistent effects on dust mite levels and asthma. The challenge is to further refine the interventions in large placebo-controlled trials such that clinical outcomes may be more easily demonstrated.

No MeSH data available.


Related in: MedlinePlus

Dot plot illustrating the individual concentrations of the major house dust mite allergen Der p1 measured as µg per g of settled house dust collected from carpets in 139 randomly selected houses in the West of Scotland.
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fig3: Dot plot illustrating the individual concentrations of the major house dust mite allergen Der p1 measured as µg per g of settled house dust collected from carpets in 139 randomly selected houses in the West of Scotland.

Mentions: Scotland has the highest incidence of adolescent asthma in the world. We quantified the allergen content in carpets in 139 randomly selected Scottish homes. The dot plot in Figure 3 highlights the distribution of HDM allergen concentration. About two thirds of the carpets had levels above the WHO recommended sensitization limit of 2 µg/g (Figure 3; lower line), and about half had levels greater than the recommended clinical safety limit of 10 µg/g (Figure 3; higher line).


House dust mite control measures in the treatment of asthma.

Vallance G, McSharry C, Wood S, Thomson NC - Ther Clin Risk Manag (2006)

Dot plot illustrating the individual concentrations of the major house dust mite allergen Der p1 measured as µg per g of settled house dust collected from carpets in 139 randomly selected houses in the West of Scotland.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1936356&req=5

fig3: Dot plot illustrating the individual concentrations of the major house dust mite allergen Der p1 measured as µg per g of settled house dust collected from carpets in 139 randomly selected houses in the West of Scotland.
Mentions: Scotland has the highest incidence of adolescent asthma in the world. We quantified the allergen content in carpets in 139 randomly selected Scottish homes. The dot plot in Figure 3 highlights the distribution of HDM allergen concentration. About two thirds of the carpets had levels above the WHO recommended sensitization limit of 2 µg/g (Figure 3; lower line), and about half had levels greater than the recommended clinical safety limit of 10 µg/g (Figure 3; higher line).

Bottom Line: Sensitization to the house dust mite (Dermataphagoides pteronyssinus) (HDM) is the most common risk factor associated with the development of asthma in adults and children.However, a recent multi-allergen reduction approach has suggested benefits may be achievable.HDM densities tend to be high in warm, humid conditions in the home, which may be modified by external factors, such as ventilation.

View Article: PubMed Central - PubMed

ABSTRACT
Sensitization to the house dust mite (Dermataphagoides pteronyssinus) (HDM) is the most common risk factor associated with the development of asthma in adults and children. The effectiveness of HDM control measures in the treatment of asthma is not yet proven. The strategies for control for avoidance depend on our understanding of the biology of the HDM. The evidence suggests a favorable effect of transferring allergic asthmatic children to naturally low dust mite environments, such as at altitude or in hospital, but little to suggest that this can be replicated in general practice by simple practical measures such as mattress covers. However, a recent multi-allergen reduction approach has suggested benefits may be achievable. HDM densities tend to be high in warm, humid conditions in the home, which may be modified by external factors, such as ventilation. However, ventilation control to reduce indoor humidity has had inconsistent effects on dust mite levels and asthma. The challenge is to further refine the interventions in large placebo-controlled trials such that clinical outcomes may be more easily demonstrated.

No MeSH data available.


Related in: MedlinePlus