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Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation.

Kendirci M, Salem E, Hellstrom WJ - Ther Clin Risk Manag (2007)

Bottom Line: Apart from a number of behavioral approaches, the treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitors (SSRIs) via either on-demand or daily delivery.However, various undesirable side-effects of these medications have led researchers to search for and develop new therapeutic approaches for PE.Dapoxetine is a short-acting SSRI developed specifically for the treatment of PE.

View Article: PubMed Central - PubMed

ABSTRACT
Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. Over the past one or two decades, clinical investigators have participated in an increasing number of studies that are helping in our understanding of PE, which will undoubtedly facilitate future treatments. Apart from a number of behavioral approaches, the treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitors (SSRIs) via either on-demand or daily delivery. However, various undesirable side-effects of these medications have led researchers to search for and develop new therapeutic approaches for PE. Dapoxetine is a short-acting SSRI developed specifically for the treatment of PE. Early trials with dapoxetine have documented successful outcomes without serious short- or long-term side-effects. This review addresses the definition, classification, diagnosis, physiology, and neurobiopathology of PE, and evaluates therapeutic strategies with novel treatments for PE.

No MeSH data available.


Related in: MedlinePlus

Non-pharmacological treatment options for PE.Adapted from Shenassa and Hellstrom (2001).
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fig1: Non-pharmacological treatment options for PE.Adapted from Shenassa and Hellstrom (2001).

Mentions: The stop-start technique has since been popularized by Kaplan in 1983. In this technique the man is asked to pause during sexual stimulation, just prior to impending ejaculation. This pause allows the patient to acclimatize to the sensation and to condition himself to increased ejaculatory control. This technique helps the patient to heighten his awareness of sexual sensations. Unfortunately, many others have found that any initial success achieved by behavioral therapy was not maintained at 3-year follow-up (Sharlip 2005). Non-pharmacological treatment options for PE are provided in Figure 1.


Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation.

Kendirci M, Salem E, Hellstrom WJ - Ther Clin Risk Manag (2007)

Non-pharmacological treatment options for PE.Adapted from Shenassa and Hellstrom (2001).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1936309&req=5

fig1: Non-pharmacological treatment options for PE.Adapted from Shenassa and Hellstrom (2001).
Mentions: The stop-start technique has since been popularized by Kaplan in 1983. In this technique the man is asked to pause during sexual stimulation, just prior to impending ejaculation. This pause allows the patient to acclimatize to the sensation and to condition himself to increased ejaculatory control. This technique helps the patient to heighten his awareness of sexual sensations. Unfortunately, many others have found that any initial success achieved by behavioral therapy was not maintained at 3-year follow-up (Sharlip 2005). Non-pharmacological treatment options for PE are provided in Figure 1.

Bottom Line: Apart from a number of behavioral approaches, the treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitors (SSRIs) via either on-demand or daily delivery.However, various undesirable side-effects of these medications have led researchers to search for and develop new therapeutic approaches for PE.Dapoxetine is a short-acting SSRI developed specifically for the treatment of PE.

View Article: PubMed Central - PubMed

ABSTRACT
Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. Over the past one or two decades, clinical investigators have participated in an increasing number of studies that are helping in our understanding of PE, which will undoubtedly facilitate future treatments. Apart from a number of behavioral approaches, the treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitors (SSRIs) via either on-demand or daily delivery. However, various undesirable side-effects of these medications have led researchers to search for and develop new therapeutic approaches for PE. Dapoxetine is a short-acting SSRI developed specifically for the treatment of PE. Early trials with dapoxetine have documented successful outcomes without serious short- or long-term side-effects. This review addresses the definition, classification, diagnosis, physiology, and neurobiopathology of PE, and evaluates therapeutic strategies with novel treatments for PE.

No MeSH data available.


Related in: MedlinePlus