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Stable isotope ratios in hair and teeth reflect biologic rhythms.

Appenzeller O, Qualls C, Barbic F, Furlan R, Porta A - PLoS ONE (2007)

Bottom Line: We found recurring circa-annual periods of slow and fast rhythms in hydrogen isotope ratios in hair and carbon and oxygen isotope ratios in teeth.The power spectra contained slow and fast frequency power, matching, in terms of normalized frequency, the spectra of heart rate variability found in our living subjects.Our study shows that spectral analysis of stable isotope ratios in readily available tissues such as hair could become a powerful diagnostic tool when effective treatments and neuroprotective drugs for neurodegenerative diseases become available.

View Article: PubMed Central - PubMed

Affiliation: New Mexico Health Enhancement and Marathon Clinics Research Foundation, Albuquerque, New Mexico, United States of America. oarun@unm.edu

ABSTRACT
Biologic rhythms give insight into normal physiology and disease. They can be used as biomarkers for neuronal degenerations. We present a diverse data set to show that hair and teeth contain an extended record of biologic rhythms, and that analysis of these tissues could yield signals of neurodegenerations. We examined hair from mummified humans from South America, extinct mammals and modern animals and people, both healthy and diseased, and teeth of hominins. We also monitored heart-rate variability, a measure of a biologic rhythm, in some living subjects and analyzed it using power spectra. The samples were examined to determine variations in stable isotope ratios along the length of the hair and across growth-lines of the enamel in teeth. We found recurring circa-annual periods of slow and fast rhythms in hydrogen isotope ratios in hair and carbon and oxygen isotope ratios in teeth. The power spectra contained slow and fast frequency power, matching, in terms of normalized frequency, the spectra of heart rate variability found in our living subjects. Analysis of the power spectra of hydrogen isotope ratios in hair from a patient with neurodegeneration revealed the same spectral features seen in the patient's heart-rate variability. Our study shows that spectral analysis of stable isotope ratios in readily available tissues such as hair could become a powerful diagnostic tool when effective treatments and neuroprotective drugs for neurodegenerative diseases become available. It also suggests that similar analyses of archaeological specimens could give insight into the physiology of ancient people and animals.

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Related in: MedlinePlus

Power spectra derived from hydrogen isotope ratios in hair of humans (A) and oxygen isotope ratios in Paranthropus robustus teeth (B).Note that the slow and fast power peaks, in terms of normalized frequencies, are similar to those derived from power spectra of heart rate variability of the Italian subject and especially the virtual absence of frequency modulations in the patient with PAF (see Figure 3). X =  very slow frequency cycling at 32 weeks.The frequency of spectral power peaks of hydrogen isotope ratios in hair in the normal human and oxygen isotope ratios in Paranthropus robustus is also very similar (B) giving additional support to the influence of the ANS on biologic rhythms derived from different tissues.
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pone-0000636-g002: Power spectra derived from hydrogen isotope ratios in hair of humans (A) and oxygen isotope ratios in Paranthropus robustus teeth (B).Note that the slow and fast power peaks, in terms of normalized frequencies, are similar to those derived from power spectra of heart rate variability of the Italian subject and especially the virtual absence of frequency modulations in the patient with PAF (see Figure 3). X =  very slow frequency cycling at 32 weeks.The frequency of spectral power peaks of hydrogen isotope ratios in hair in the normal human and oxygen isotope ratios in Paranthropus robustus is also very similar (B) giving additional support to the influence of the ANS on biologic rhythms derived from different tissues.

Mentions: The power spectral densities of the hydrogen isotope ratios obtained from hair are given in Figure 2.


Stable isotope ratios in hair and teeth reflect biologic rhythms.

Appenzeller O, Qualls C, Barbic F, Furlan R, Porta A - PLoS ONE (2007)

Power spectra derived from hydrogen isotope ratios in hair of humans (A) and oxygen isotope ratios in Paranthropus robustus teeth (B).Note that the slow and fast power peaks, in terms of normalized frequencies, are similar to those derived from power spectra of heart rate variability of the Italian subject and especially the virtual absence of frequency modulations in the patient with PAF (see Figure 3). X =  very slow frequency cycling at 32 weeks.The frequency of spectral power peaks of hydrogen isotope ratios in hair in the normal human and oxygen isotope ratios in Paranthropus robustus is also very similar (B) giving additional support to the influence of the ANS on biologic rhythms derived from different tissues.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1919425&req=5

pone-0000636-g002: Power spectra derived from hydrogen isotope ratios in hair of humans (A) and oxygen isotope ratios in Paranthropus robustus teeth (B).Note that the slow and fast power peaks, in terms of normalized frequencies, are similar to those derived from power spectra of heart rate variability of the Italian subject and especially the virtual absence of frequency modulations in the patient with PAF (see Figure 3). X =  very slow frequency cycling at 32 weeks.The frequency of spectral power peaks of hydrogen isotope ratios in hair in the normal human and oxygen isotope ratios in Paranthropus robustus is also very similar (B) giving additional support to the influence of the ANS on biologic rhythms derived from different tissues.
Mentions: The power spectral densities of the hydrogen isotope ratios obtained from hair are given in Figure 2.

Bottom Line: We found recurring circa-annual periods of slow and fast rhythms in hydrogen isotope ratios in hair and carbon and oxygen isotope ratios in teeth.The power spectra contained slow and fast frequency power, matching, in terms of normalized frequency, the spectra of heart rate variability found in our living subjects.Our study shows that spectral analysis of stable isotope ratios in readily available tissues such as hair could become a powerful diagnostic tool when effective treatments and neuroprotective drugs for neurodegenerative diseases become available.

View Article: PubMed Central - PubMed

Affiliation: New Mexico Health Enhancement and Marathon Clinics Research Foundation, Albuquerque, New Mexico, United States of America. oarun@unm.edu

ABSTRACT
Biologic rhythms give insight into normal physiology and disease. They can be used as biomarkers for neuronal degenerations. We present a diverse data set to show that hair and teeth contain an extended record of biologic rhythms, and that analysis of these tissues could yield signals of neurodegenerations. We examined hair from mummified humans from South America, extinct mammals and modern animals and people, both healthy and diseased, and teeth of hominins. We also monitored heart-rate variability, a measure of a biologic rhythm, in some living subjects and analyzed it using power spectra. The samples were examined to determine variations in stable isotope ratios along the length of the hair and across growth-lines of the enamel in teeth. We found recurring circa-annual periods of slow and fast rhythms in hydrogen isotope ratios in hair and carbon and oxygen isotope ratios in teeth. The power spectra contained slow and fast frequency power, matching, in terms of normalized frequency, the spectra of heart rate variability found in our living subjects. Analysis of the power spectra of hydrogen isotope ratios in hair from a patient with neurodegeneration revealed the same spectral features seen in the patient's heart-rate variability. Our study shows that spectral analysis of stable isotope ratios in readily available tissues such as hair could become a powerful diagnostic tool when effective treatments and neuroprotective drugs for neurodegenerative diseases become available. It also suggests that similar analyses of archaeological specimens could give insight into the physiology of ancient people and animals.

Show MeSH
Related in: MedlinePlus