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Liver fluke induces cholangiocarcinoma.

Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ - PLoS Med. (2007)

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Khon Kaen University, Khon Kaen, Thailand. banchob@kku.ac.th

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Related in: MedlinePlus

Incidence of CCA and O. viverrini in Thailand from 1990–2001Increasing intensity of red represents increasing prevalence of O. viverrini, while increasing number of dots represents increasing cancer rates. In general, higher O. viverrini prevalence correlates with a higher CCA burden, although sporadic anthelmintic therapy has influenced this relationship. It should be noted that even one spot represents significant cancer rates anywhere else in the world. *Truncated age-standardised incidence from 35–64 years. **Age-standardised incidence of CCA throughout registered regions. Adapted from [20].
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pmed-0040201.g003: Incidence of CCA and O. viverrini in Thailand from 1990–2001Increasing intensity of red represents increasing prevalence of O. viverrini, while increasing number of dots represents increasing cancer rates. In general, higher O. viverrini prevalence correlates with a higher CCA burden, although sporadic anthelmintic therapy has influenced this relationship. It should be noted that even one spot represents significant cancer rates anywhere else in the world. *Truncated age-standardised incidence from 35–64 years. **Age-standardised incidence of CCA throughout registered regions. Adapted from [20].

Mentions: In Thailand, the first evidence for such an association came from hospital case series. CCA was observed in a high percentage of liver cancers from northeast Thailand, where the prevalence of O. viverrini infection is higher than elsewhere in this country [19]. More formal correlation studies showed that the incidence of CCA in the five major regions of Thailand varied by at least 12-fold and had a strong positive correlation with the prevalence of O. viverrini infection, as measured by anti-O. viverrini antibody titres in the general population (Figure 3) [20,21]. Similar correlations have been observed in populations in Laos [22,23]. Hepatocellular carcinoma (HCC) shows no such relationship.


Liver fluke induces cholangiocarcinoma.

Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ - PLoS Med. (2007)

Incidence of CCA and O. viverrini in Thailand from 1990–2001Increasing intensity of red represents increasing prevalence of O. viverrini, while increasing number of dots represents increasing cancer rates. In general, higher O. viverrini prevalence correlates with a higher CCA burden, although sporadic anthelmintic therapy has influenced this relationship. It should be noted that even one spot represents significant cancer rates anywhere else in the world. *Truncated age-standardised incidence from 35–64 years. **Age-standardised incidence of CCA throughout registered regions. Adapted from [20].
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1913093&req=5

pmed-0040201.g003: Incidence of CCA and O. viverrini in Thailand from 1990–2001Increasing intensity of red represents increasing prevalence of O. viverrini, while increasing number of dots represents increasing cancer rates. In general, higher O. viverrini prevalence correlates with a higher CCA burden, although sporadic anthelmintic therapy has influenced this relationship. It should be noted that even one spot represents significant cancer rates anywhere else in the world. *Truncated age-standardised incidence from 35–64 years. **Age-standardised incidence of CCA throughout registered regions. Adapted from [20].
Mentions: In Thailand, the first evidence for such an association came from hospital case series. CCA was observed in a high percentage of liver cancers from northeast Thailand, where the prevalence of O. viverrini infection is higher than elsewhere in this country [19]. More formal correlation studies showed that the incidence of CCA in the five major regions of Thailand varied by at least 12-fold and had a strong positive correlation with the prevalence of O. viverrini infection, as measured by anti-O. viverrini antibody titres in the general population (Figure 3) [20,21]. Similar correlations have been observed in populations in Laos [22,23]. Hepatocellular carcinoma (HCC) shows no such relationship.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Khon Kaen University, Khon Kaen, Thailand. banchob@kku.ac.th

Show MeSH
Related in: MedlinePlus