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Atrial and placental melanoma metastasis: a case report and literature review.

Lakshminarayana P, Danson S, Suvarna K, Hancock B - J Med Case Rep (2007)

Bottom Line: Malignant melanoma can metastasize to virtually any organ of the body.The aggressiveness is determined by the primary site, depth of dermal invasion, presence or absence of ulceration, lymphovascular infiltration and regional lymph node involvement.A review of literature on cardiac and placental involvement of melanoma is also provided.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Clinical Oncology, Weston Park Hospital, Whitham Road, Sheffield, S10 2SJ, UK. drpradeephl@yahoo.co.uk.

ABSTRACT
Malignant melanoma can metastasize to virtually any organ of the body. The aggressiveness is determined by the primary site, depth of dermal invasion, presence or absence of ulceration, lymphovascular infiltration and regional lymph node involvement. We report a case of a pregnant woman with a previous history of stage 3 melanoma who presented with cardiac metastasis and placental melanoma infiltration. A review of literature on cardiac and placental involvement of melanoma is also provided.

No MeSH data available.


Related in: MedlinePlus

Histopathology: A. Endomyocardial biopsy showed pleomorphic malignant melanoma(mm) with associated necrosis (original magnification × 200). B. Placental tissue shows villous tissue(v) with foci of malignant melanoma(mm) (original magnification × 200).
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Figure 2: Histopathology: A. Endomyocardial biopsy showed pleomorphic malignant melanoma(mm) with associated necrosis (original magnification × 200). B. Placental tissue shows villous tissue(v) with foci of malignant melanoma(mm) (original magnification × 200).

Mentions: An MRI scan of the heart confirmed the mass to be more extensive measuring 8 cm in size and extending into the superior vena cava (fig 1). An echocardiogram guided biopsy of the mass (fig 2A) revealed necrotic tumour with associated thrombus and adjacent normal myocardium. The viable tumour was composed of moderately pleomorphic epitheliod melanocyes (S100/HMB45 positive) with enlarged pleomorphic nuclei and prominent nucleoli.


Atrial and placental melanoma metastasis: a case report and literature review.

Lakshminarayana P, Danson S, Suvarna K, Hancock B - J Med Case Rep (2007)

Histopathology: A. Endomyocardial biopsy showed pleomorphic malignant melanoma(mm) with associated necrosis (original magnification × 200). B. Placental tissue shows villous tissue(v) with foci of malignant melanoma(mm) (original magnification × 200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1878489&req=5

Figure 2: Histopathology: A. Endomyocardial biopsy showed pleomorphic malignant melanoma(mm) with associated necrosis (original magnification × 200). B. Placental tissue shows villous tissue(v) with foci of malignant melanoma(mm) (original magnification × 200).
Mentions: An MRI scan of the heart confirmed the mass to be more extensive measuring 8 cm in size and extending into the superior vena cava (fig 1). An echocardiogram guided biopsy of the mass (fig 2A) revealed necrotic tumour with associated thrombus and adjacent normal myocardium. The viable tumour was composed of moderately pleomorphic epitheliod melanocyes (S100/HMB45 positive) with enlarged pleomorphic nuclei and prominent nucleoli.

Bottom Line: Malignant melanoma can metastasize to virtually any organ of the body.The aggressiveness is determined by the primary site, depth of dermal invasion, presence or absence of ulceration, lymphovascular infiltration and regional lymph node involvement.A review of literature on cardiac and placental involvement of melanoma is also provided.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Clinical Oncology, Weston Park Hospital, Whitham Road, Sheffield, S10 2SJ, UK. drpradeephl@yahoo.co.uk.

ABSTRACT
Malignant melanoma can metastasize to virtually any organ of the body. The aggressiveness is determined by the primary site, depth of dermal invasion, presence or absence of ulceration, lymphovascular infiltration and regional lymph node involvement. We report a case of a pregnant woman with a previous history of stage 3 melanoma who presented with cardiac metastasis and placental melanoma infiltration. A review of literature on cardiac and placental involvement of melanoma is also provided.

No MeSH data available.


Related in: MedlinePlus