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Solitary Plasmacytoma of the Parotid Gland with Crystalline Inclusions: A Case Report.

Kanthan R, Torkian B - World J Surg Oncol (2003)

Bottom Line: BACKGROUND: Solitary extramedullary plasmacytoma of the parotid gland is a rare condition.Intracytoplasmic Crystalline inclusions in the tumor are even rarer and have been reported only once in the parotid gland.The importance of such a finding with relation to tumor progression, clinical course of the disease or prognosis in general remains to be understood.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Room 2868, G Wing, Royal University Hospital, Saskatoon, Saskatchewan, S7N OW8, CANADA. inarkanth@shaw.ca

ABSTRACT
BACKGROUND: Solitary extramedullary plasmacytoma of the parotid gland is a rare condition. Intracytoplasmic Crystalline inclusions in the tumor are even rarer and have been reported only once in the parotid gland. CASE PRESENTATION: We report here, a case of plasmacytoma of the parotid gland with intracellular crystalline inclusions in a 73-year-old woman CONCLUSION: Solitary extramedullary plasmacytoma of the parotid gland and crystalline inclusions in the tumor is of rare occurrence. The importance of such a finding with relation to tumor progression, clinical course of the disease or prognosis in general remains to be understood.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical analysis Immunohistochemical staining shows the plasma cells to be IgG positive with kappa restriction pattern (medium power × 250)
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Figure 4: Immunohistochemical analysis Immunohistochemical staining shows the plasma cells to be IgG positive with kappa restriction pattern (medium power × 250)

Mentions: A 73-year-old Caucasian female was investigated at the Royal University Hospital of Saskatoon, Canada, for a non-tender mobile mass at the angle of the right mandible with a history of recent rapid growth over the past two months. Clinical examination was otherwise non-contributory. Past medical history included psoriasis, hypertension and osteoarthritis of both hip joints and treated Hodgkin's lymphoma 10 years back. Cytology of the fine needle aspiration of the parotid mass showed numerous polymorphic lymphocytes (Figure 1). Subsequently a superficial parotidectomy with conservation of the facial nerve was performed. Histopathological examination of the excised mass at initial frozen section analysis revealed the parotid gland to be completely replaced by sheets of lesional cells that were non-salivary in origin. Detailed pathological analysis showed sheets of plasma cells and plasmacytoid cells with a fair number of the plasma cells and histiocytes containing crystalline inclusion bodies many of which were linearly profiled and of multiple shapes (Figure 2, 3). Multiple cytoplasmic globules (Russell bodies), some nuclear inclusion like structures (Dutcher bodies), mild nuclear atypia and rare mitosis were also observed. Immuno-histochemical staining showed the plasma cells to be monoclonal (kappa restricted) and the small lymphoid cells in the background to be predominantly T-cells (CD45RO+), along with a smaller proportion of B-cells (CD20+) (Figure 4). A complete multiple myeloma work-up, including bone marrow biopsy, total body skeletal survey, immunoelectrophoresis, quantitative immunoglobulins and urinary Bence Jones proteins remained negative. She developed local recurrence of her disease 18 months and 30 months later, which was managed by both radiotherapy and chemotherapy. Her clinical follow up for two years has remained uneventful.


Solitary Plasmacytoma of the Parotid Gland with Crystalline Inclusions: A Case Report.

Kanthan R, Torkian B - World J Surg Oncol (2003)

Immunohistochemical analysis Immunohistochemical staining shows the plasma cells to be IgG positive with kappa restriction pattern (medium power × 250)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC184446&req=5

Figure 4: Immunohistochemical analysis Immunohistochemical staining shows the plasma cells to be IgG positive with kappa restriction pattern (medium power × 250)
Mentions: A 73-year-old Caucasian female was investigated at the Royal University Hospital of Saskatoon, Canada, for a non-tender mobile mass at the angle of the right mandible with a history of recent rapid growth over the past two months. Clinical examination was otherwise non-contributory. Past medical history included psoriasis, hypertension and osteoarthritis of both hip joints and treated Hodgkin's lymphoma 10 years back. Cytology of the fine needle aspiration of the parotid mass showed numerous polymorphic lymphocytes (Figure 1). Subsequently a superficial parotidectomy with conservation of the facial nerve was performed. Histopathological examination of the excised mass at initial frozen section analysis revealed the parotid gland to be completely replaced by sheets of lesional cells that were non-salivary in origin. Detailed pathological analysis showed sheets of plasma cells and plasmacytoid cells with a fair number of the plasma cells and histiocytes containing crystalline inclusion bodies many of which were linearly profiled and of multiple shapes (Figure 2, 3). Multiple cytoplasmic globules (Russell bodies), some nuclear inclusion like structures (Dutcher bodies), mild nuclear atypia and rare mitosis were also observed. Immuno-histochemical staining showed the plasma cells to be monoclonal (kappa restricted) and the small lymphoid cells in the background to be predominantly T-cells (CD45RO+), along with a smaller proportion of B-cells (CD20+) (Figure 4). A complete multiple myeloma work-up, including bone marrow biopsy, total body skeletal survey, immunoelectrophoresis, quantitative immunoglobulins and urinary Bence Jones proteins remained negative. She developed local recurrence of her disease 18 months and 30 months later, which was managed by both radiotherapy and chemotherapy. Her clinical follow up for two years has remained uneventful.

Bottom Line: BACKGROUND: Solitary extramedullary plasmacytoma of the parotid gland is a rare condition.Intracytoplasmic Crystalline inclusions in the tumor are even rarer and have been reported only once in the parotid gland.The importance of such a finding with relation to tumor progression, clinical course of the disease or prognosis in general remains to be understood.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Room 2868, G Wing, Royal University Hospital, Saskatoon, Saskatchewan, S7N OW8, CANADA. inarkanth@shaw.ca

ABSTRACT
BACKGROUND: Solitary extramedullary plasmacytoma of the parotid gland is a rare condition. Intracytoplasmic Crystalline inclusions in the tumor are even rarer and have been reported only once in the parotid gland. CASE PRESENTATION: We report here, a case of plasmacytoma of the parotid gland with intracellular crystalline inclusions in a 73-year-old woman CONCLUSION: Solitary extramedullary plasmacytoma of the parotid gland and crystalline inclusions in the tumor is of rare occurrence. The importance of such a finding with relation to tumor progression, clinical course of the disease or prognosis in general remains to be understood.

No MeSH data available.


Related in: MedlinePlus