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The new variant of the Creutzfeldt-Jakob disease accounts for no relative increase of the Creutzfeldt-Jakob disease mortality rate in the United Kingdom; this fits ill with the new variant being the consequence of consumption of food infected with the agent of Bovine Spongiform Encephalopathy.

Laprevotte I, Hénaut A - BMC Public Health (2003)

Bottom Line: Unexpectedly, for the United Kingdom where all but a few cases of the new variant have been reported, these cases have to be included in the incidence curve of the sporadic forms of the disease in order to obtain the best fit with the median curve from all the countries.In any case, public health recommendations hold and further investigation is required.The lack of a relative increase of the Creutzfeldt-Jakob-disease mortality rate in the United Kingdom, does not fit well with the new variant being the consequence of consumption of food infected with the agent of bovine spongiform encephalopthy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratoire Génome et Informatique, UMR CNRS 8116, Tour Evry 2, 523 Place des Terrasses, 91034 Evry Cedex, France. laprevot@genopole.cnrs.fr

ABSTRACT

Background: A new variant of Creutzfeldt-Jakob disease was described in the United Kingdom. It is often claimed that it is caused by consumption of food infected with the agent of bovine spongiform encephalopathy. However, this remains open to question because the number of cases of the variant is, at the present time, less than would be expected from a major food-borne source.

Discussion: The EUROCJD cooperative study presents currently available epidemiological data of Creutzfeldt-Jakob disease and its new variant, for nine European countries plus Australia and Canada. Unexpectedly, for the United Kingdom where all but a few cases of the new variant have been reported, these cases have to be included in the incidence curve of the sporadic forms of the disease in order to obtain the best fit with the median curve from all the countries. This variant could be merely a rare clinical phenotype within the sporadic disease. The published clinical and experimental data which suggest that it is linked with bovine spongiform encephalopathy, lead us to propose that this link could be a common etiological origin other than consumption of bovine infected food. In any case, public health recommendations hold and further investigation is required.

Summary: The lack of a relative increase of the Creutzfeldt-Jakob-disease mortality rate in the United Kingdom, does not fit well with the new variant being the consequence of consumption of food infected with the agent of bovine spongiform encephalopthy.

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Annual mortality ratio (9 countries). Annual mortality ratios per million (sporadic CJD + nvCJD) for the UK and eight other countries included in the EUROCJD project (see text). Two curves correspond to the UK data, the nvCJD cases being excluded from one of them (broken line). The three other curves summarize the data from the nine countries together: for each year, three values out of the nine observed, are plotted corresponding to the curves Max, for the maximum number, Min for the minimum value and Median (fifth value or, for 1993, the average of fourth and fifth). The last year indicated is 2001 (statistics as at 31 December 2002, 6 March 2003 for France and 3 March 2003 for the UK)
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Figure 1: Annual mortality ratio (9 countries). Annual mortality ratios per million (sporadic CJD + nvCJD) for the UK and eight other countries included in the EUROCJD project (see text). Two curves correspond to the UK data, the nvCJD cases being excluded from one of them (broken line). The three other curves summarize the data from the nine countries together: for each year, three values out of the nine observed, are plotted corresponding to the curves Max, for the maximum number, Min for the minimum value and Median (fifth value or, for 1993, the average of fourth and fifth). The last year indicated is 2001 (statistics as at 31 December 2002, 6 March 2003 for France and 3 March 2003 for the UK)


The new variant of the Creutzfeldt-Jakob disease accounts for no relative increase of the Creutzfeldt-Jakob disease mortality rate in the United Kingdom; this fits ill with the new variant being the consequence of consumption of food infected with the agent of Bovine Spongiform Encephalopathy.

Laprevotte I, Hénaut A - BMC Public Health (2003)

Annual mortality ratio (9 countries). Annual mortality ratios per million (sporadic CJD + nvCJD) for the UK and eight other countries included in the EUROCJD project (see text). Two curves correspond to the UK data, the nvCJD cases being excluded from one of them (broken line). The three other curves summarize the data from the nine countries together: for each year, three values out of the nine observed, are plotted corresponding to the curves Max, for the maximum number, Min for the minimum value and Median (fifth value or, for 1993, the average of fourth and fifth). The last year indicated is 2001 (statistics as at 31 December 2002, 6 March 2003 for France and 3 March 2003 for the UK)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC184443&req=5

Figure 1: Annual mortality ratio (9 countries). Annual mortality ratios per million (sporadic CJD + nvCJD) for the UK and eight other countries included in the EUROCJD project (see text). Two curves correspond to the UK data, the nvCJD cases being excluded from one of them (broken line). The three other curves summarize the data from the nine countries together: for each year, three values out of the nine observed, are plotted corresponding to the curves Max, for the maximum number, Min for the minimum value and Median (fifth value or, for 1993, the average of fourth and fifth). The last year indicated is 2001 (statistics as at 31 December 2002, 6 March 2003 for France and 3 March 2003 for the UK)
Bottom Line: Unexpectedly, for the United Kingdom where all but a few cases of the new variant have been reported, these cases have to be included in the incidence curve of the sporadic forms of the disease in order to obtain the best fit with the median curve from all the countries.In any case, public health recommendations hold and further investigation is required.The lack of a relative increase of the Creutzfeldt-Jakob-disease mortality rate in the United Kingdom, does not fit well with the new variant being the consequence of consumption of food infected with the agent of bovine spongiform encephalopthy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratoire Génome et Informatique, UMR CNRS 8116, Tour Evry 2, 523 Place des Terrasses, 91034 Evry Cedex, France. laprevot@genopole.cnrs.fr

ABSTRACT

Background: A new variant of Creutzfeldt-Jakob disease was described in the United Kingdom. It is often claimed that it is caused by consumption of food infected with the agent of bovine spongiform encephalopathy. However, this remains open to question because the number of cases of the variant is, at the present time, less than would be expected from a major food-borne source.

Discussion: The EUROCJD cooperative study presents currently available epidemiological data of Creutzfeldt-Jakob disease and its new variant, for nine European countries plus Australia and Canada. Unexpectedly, for the United Kingdom where all but a few cases of the new variant have been reported, these cases have to be included in the incidence curve of the sporadic forms of the disease in order to obtain the best fit with the median curve from all the countries. This variant could be merely a rare clinical phenotype within the sporadic disease. The published clinical and experimental data which suggest that it is linked with bovine spongiform encephalopathy, lead us to propose that this link could be a common etiological origin other than consumption of bovine infected food. In any case, public health recommendations hold and further investigation is required.

Summary: The lack of a relative increase of the Creutzfeldt-Jakob-disease mortality rate in the United Kingdom, does not fit well with the new variant being the consequence of consumption of food infected with the agent of bovine spongiform encephalopthy.

Show MeSH
Related in: MedlinePlus