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Optical mammography: a new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: preliminary results with radiologic-pathologic correlation.

Athanasiou A, Vanel D, Fournier L, Balleyguier C - Cancer Imaging (2007)

Bottom Line: We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS).False positive results were seen in benign proliferative lesions.Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.

View Article: PubMed Central - PubMed

Affiliation: Institut Gustav Roussy, France.

ABSTRACT
The purpose of this prospective study is to determine the diagnostic accuracy of near-infrared breast optical absorption imaging in patients with Breast Imaging Reporting and Data System (BIRADS) 4-5 non-palpable lesions scheduled for biopsy, using pathology after core or excisional biopsy as a reference. The patient's breast was positioned onto a panel of red light-emitting diodes (640 nm). A soft membrane was inflated to exert a uniform pressure on the breast. Transmitted light was detected using a CCD camera. The entire acquisition sequence took 1 minute. Image processing generated dynamic images displayed in colour scale, to reveal time-dependent changes in the transmitted light intensity caused by the pressure change. Dynamic curves were classified in two categories: consistently decreasing intensity suspicious for malignancy, and sinusoidal increasing intensity considered as benign. Seventy-eight women consulting for non-palpable breast lesions were initially included in the study. An imaging-histology correlation was obtained for seventy-two patients, the remaining six patients were excluded for technical optical scan reasons. We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS). False positive results were seen in benign proliferative lesions. Dynamic optical breast imaging is a novel, low-cost, non-invasive technique yielding a new type of information about the physiology of breast lesions. Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.

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Case 1. (a) Mammographic images in craniocaudal view clearly depict a stellated lesion classified as BIRADS 5, with a high suspicion of malignancy. (b) High-resolution ultrasonography with a 10 mHz probe shows that the mammographic lesion corresponds to a hypoechoic, irregular nodule, BIRADS 5. (c) Dynamic optical imaging shows that the corresponding area of interest is highly hypoxic, with negative down slope dynamic curves, that strongly suggest an underlying malignant lesion.
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Figure 3: Case 1. (a) Mammographic images in craniocaudal view clearly depict a stellated lesion classified as BIRADS 5, with a high suspicion of malignancy. (b) High-resolution ultrasonography with a 10 mHz probe shows that the mammographic lesion corresponds to a hypoechoic, irregular nodule, BIRADS 5. (c) Dynamic optical imaging shows that the corresponding area of interest is highly hypoxic, with negative down slope dynamic curves, that strongly suggest an underlying malignant lesion.

Mentions: Case 1 shows a typical BIRADS 5 lesion for which dynamic optical imaging was also positive: mammography depicted a spiculated opacity with irregular borders (Fig. 3a) corresponding to a hypoechoic, irregular nodule at ultrasonography (Fig. 3b). Dynamic optical acquisition was strongly suggestive of an underlying malignancy, detecting a blue-coloured, hypoxic area with negative dynamic curves (Fig. 3c). This lesion was found to correspond to an invasive ductal carcinoma at histology.


Optical mammography: a new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: preliminary results with radiologic-pathologic correlation.

Athanasiou A, Vanel D, Fournier L, Balleyguier C - Cancer Imaging (2007)

Case 1. (a) Mammographic images in craniocaudal view clearly depict a stellated lesion classified as BIRADS 5, with a high suspicion of malignancy. (b) High-resolution ultrasonography with a 10 mHz probe shows that the mammographic lesion corresponds to a hypoechoic, irregular nodule, BIRADS 5. (c) Dynamic optical imaging shows that the corresponding area of interest is highly hypoxic, with negative down slope dynamic curves, that strongly suggest an underlying malignant lesion.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1828368&req=5

Figure 3: Case 1. (a) Mammographic images in craniocaudal view clearly depict a stellated lesion classified as BIRADS 5, with a high suspicion of malignancy. (b) High-resolution ultrasonography with a 10 mHz probe shows that the mammographic lesion corresponds to a hypoechoic, irregular nodule, BIRADS 5. (c) Dynamic optical imaging shows that the corresponding area of interest is highly hypoxic, with negative down slope dynamic curves, that strongly suggest an underlying malignant lesion.
Mentions: Case 1 shows a typical BIRADS 5 lesion for which dynamic optical imaging was also positive: mammography depicted a spiculated opacity with irregular borders (Fig. 3a) corresponding to a hypoechoic, irregular nodule at ultrasonography (Fig. 3b). Dynamic optical acquisition was strongly suggestive of an underlying malignancy, detecting a blue-coloured, hypoxic area with negative dynamic curves (Fig. 3c). This lesion was found to correspond to an invasive ductal carcinoma at histology.

Bottom Line: We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS).False positive results were seen in benign proliferative lesions.Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.

View Article: PubMed Central - PubMed

Affiliation: Institut Gustav Roussy, France.

ABSTRACT
The purpose of this prospective study is to determine the diagnostic accuracy of near-infrared breast optical absorption imaging in patients with Breast Imaging Reporting and Data System (BIRADS) 4-5 non-palpable lesions scheduled for biopsy, using pathology after core or excisional biopsy as a reference. The patient's breast was positioned onto a panel of red light-emitting diodes (640 nm). A soft membrane was inflated to exert a uniform pressure on the breast. Transmitted light was detected using a CCD camera. The entire acquisition sequence took 1 minute. Image processing generated dynamic images displayed in colour scale, to reveal time-dependent changes in the transmitted light intensity caused by the pressure change. Dynamic curves were classified in two categories: consistently decreasing intensity suspicious for malignancy, and sinusoidal increasing intensity considered as benign. Seventy-eight women consulting for non-palpable breast lesions were initially included in the study. An imaging-histology correlation was obtained for seventy-two patients, the remaining six patients were excluded for technical optical scan reasons. We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS). False positive results were seen in benign proliferative lesions. Dynamic optical breast imaging is a novel, low-cost, non-invasive technique yielding a new type of information about the physiology of breast lesions. Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.

Show MeSH
Related in: MedlinePlus