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Solitary metastatic cancer to the thyroid: a report of five cases with fine-needle aspiration cytology.

Lee MW, Batoroev YK, Odashiro AN, Nguyen GK - Cytojournal (2007)

Bottom Line: Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer.In 3 cases, immunostaining of the aspirated tumor cells with thyroglobulin antibody was performed, and in 1 case an aspiration smear was stained with commercial HMB-45 antibody.All 5 patients died of metastatic disease 27 to 40 months after surgical resection of their SMCTs.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, Alberta, Canada. mwlee@cha.ab.ca

ABSTRACT
Three men and 2 women with ages ranging from 37 to 70 years, clinically and histologically confirmed solitary, palpable metastatic cancers to the thyroid (SMCT) and preoperative cytologic investigation of their thyroid lesions by fine-needle aspiration (FNA), were reviewed. Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer. Direct smears prepared from the patients' thyroid FNAs were fixed in 95% ethanol and stained with the Papanicolaou method. In 3 cases, immunostaining of the aspirated tumor cells with thyroglobulin antibody was performed, and in 1 case an aspiration smear was stained with commercial HMB-45 antibody. A correct cytodiagnosis of metastatic cancer to the thyroid was made in all 5 cases. In 1 patient the thyroid FNA revealed a metastatic RCC that led to the discovery of a clinically occult RCC. All 5 patients died of metastatic disease 27 to 40 months after surgical resection of their SMCTs.

No MeSH data available.


Related in: MedlinePlus

Histology of metastatic amelanotic melanoma to the thyroid in patient 4 shows large malignant polygonal cells with oval nuclei and prominent nucleoli, in solid pattern (hematoxylin and eosin, × 250).
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Figure 10: Histology of metastatic amelanotic melanoma to the thyroid in patient 4 shows large malignant polygonal cells with oval nuclei and prominent nucleoli, in solid pattern (hematoxylin and eosin, × 250).

Mentions: The primary tumors and the thyroid tumors in patients 1 to 4 were histologically similar and showed histologic features of a moderately differentiated bronchogenic squamous cell carcinoma, a parotid adenoid cystic carcinoma, an RCC and a cutaneous melanoma metastatic to the thyroid (Figures 7, 8, 9, 10). In patient 5 the thyroid tumor was histologically similar to the RCC of his right kidney, indicating a metastatic RCC to his thyroid.


Solitary metastatic cancer to the thyroid: a report of five cases with fine-needle aspiration cytology.

Lee MW, Batoroev YK, Odashiro AN, Nguyen GK - Cytojournal (2007)

Histology of metastatic amelanotic melanoma to the thyroid in patient 4 shows large malignant polygonal cells with oval nuclei and prominent nucleoli, in solid pattern (hematoxylin and eosin, × 250).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1808473&req=5

Figure 10: Histology of metastatic amelanotic melanoma to the thyroid in patient 4 shows large malignant polygonal cells with oval nuclei and prominent nucleoli, in solid pattern (hematoxylin and eosin, × 250).
Mentions: The primary tumors and the thyroid tumors in patients 1 to 4 were histologically similar and showed histologic features of a moderately differentiated bronchogenic squamous cell carcinoma, a parotid adenoid cystic carcinoma, an RCC and a cutaneous melanoma metastatic to the thyroid (Figures 7, 8, 9, 10). In patient 5 the thyroid tumor was histologically similar to the RCC of his right kidney, indicating a metastatic RCC to his thyroid.

Bottom Line: Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer.In 3 cases, immunostaining of the aspirated tumor cells with thyroglobulin antibody was performed, and in 1 case an aspiration smear was stained with commercial HMB-45 antibody.All 5 patients died of metastatic disease 27 to 40 months after surgical resection of their SMCTs.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, Alberta, Canada. mwlee@cha.ab.ca

ABSTRACT
Three men and 2 women with ages ranging from 37 to 70 years, clinically and histologically confirmed solitary, palpable metastatic cancers to the thyroid (SMCT) and preoperative cytologic investigation of their thyroid lesions by fine-needle aspiration (FNA), were reviewed. Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer. Direct smears prepared from the patients' thyroid FNAs were fixed in 95% ethanol and stained with the Papanicolaou method. In 3 cases, immunostaining of the aspirated tumor cells with thyroglobulin antibody was performed, and in 1 case an aspiration smear was stained with commercial HMB-45 antibody. A correct cytodiagnosis of metastatic cancer to the thyroid was made in all 5 cases. In 1 patient the thyroid FNA revealed a metastatic RCC that led to the discovery of a clinically occult RCC. All 5 patients died of metastatic disease 27 to 40 months after surgical resection of their SMCTs.

No MeSH data available.


Related in: MedlinePlus