Limits...
Bone turnover in elderly men: relationships to change in bone mineral density.

Nguyen TV, Meier C, Center JR, Eisman JA, Seibel MJ - BMC Musculoskelet Disord (2007)

Bottom Line: However, neither baseline sPINP (p = 0.50) nor baseline sICTP (p = 0.63) was associated with subsequent changes in BMD.Moreover, changes in BMD were not significantly associated with previous changes in sPINP (p = 0.13) or sICTP (p = 0.95).However, neither sPINP nor sICTP was sufficiently sensitive to predict the rate of change in BMD for a group of individuals or for an individual.

View Article: PubMed Central - HTML - PubMed

Affiliation: Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia. t.nguyen@garvan.org.au

ABSTRACT

Background: It is not clear whether bone turnover markers can be used to make inference regarding changes in bone mineral density (BMD) in untreated healthy elderly men. The present study was designed to address three specific questions: (i) is there a relationship between bone turnover markers and femoral neck BMD within an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?

Methods: The present study was part of the on-going Dubbo Osteoporosis Epidemiology Study, which was designed as a prospective investigation. Men who had had at least 3 sequential visits with serum samples available during follow-up were selected from the study population. Serum C-terminal telopeptide of type I collagen (sICTP), N-terminal propeptide of type I collagen (sPINP) and femoral neck BMD were measured by competitive radioimmunoassays. Femoral neck bone mineral density (BMD) was measured by a densitometer (GE Lunar Corp, Madison, WI). Various mixed-effects models were used to assess the association between the markers and changes in BMD.

Results: One hundred and one men aged 70 +/- 4.1 years (mean +/- SD) met the criteria of selection for analysis. On average, sPINP decreased by 0.7% per year (p = 0.026), sICTP increased by 1.7% per year (p = 0.0002), and femoral neck BMD decreased by 0.4% per year (p < 0.01). Within-subject analysis indicated that changes in BMD were significantly associated with changes in sPINP (p = 0.022), but not with changes in sICTP (p = 0.84). However, neither baseline sPINP (p = 0.50) nor baseline sICTP (p = 0.63) was associated with subsequent changes in BMD. Moreover, changes in BMD were not significantly associated with previous changes in sPINP (p = 0.13) or sICTP (p = 0.95).

Conclusion: These results suggest that in elderly men of Caucasian background, changes in sPINP were inversely related to changes in BMD within an individual. However, neither sPINP nor sICTP was sufficiently sensitive to predict the rate of change in BMD for a group of individuals or for an individual.

Show MeSH

Related in: MedlinePlus

Relationship between change in femoral neck BMD (between visit 2 and visit 1) and change in sPINP (between visit 2 and visit 1) (left panel), and change in sICTP (right panel).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC1808057&req=5

Figure 3: Relationship between change in femoral neck BMD (between visit 2 and visit 1) and change in sPINP (between visit 2 and visit 1) (left panel), and change in sICTP (right panel).

Mentions: Changes in sPINP and sICTP between visit 2 and visit 1 were not significant predictors of subsequent change in femoral neck BMD between visit 3 and visit 2 (Figure 3). However, the relationship was consistent with results from the within-subject analysis. For instance, each unit increase in sPINP between visit 2 and visit 1 was related to a subsequent decrease in femoral neck BMD of 0.6 ± 0.4 mg/cm2, but the relationship was not statistically significant (p = 0.18).


Bone turnover in elderly men: relationships to change in bone mineral density.

Nguyen TV, Meier C, Center JR, Eisman JA, Seibel MJ - BMC Musculoskelet Disord (2007)

Relationship between change in femoral neck BMD (between visit 2 and visit 1) and change in sPINP (between visit 2 and visit 1) (left panel), and change in sICTP (right panel).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1808057&req=5

Figure 3: Relationship between change in femoral neck BMD (between visit 2 and visit 1) and change in sPINP (between visit 2 and visit 1) (left panel), and change in sICTP (right panel).
Mentions: Changes in sPINP and sICTP between visit 2 and visit 1 were not significant predictors of subsequent change in femoral neck BMD between visit 3 and visit 2 (Figure 3). However, the relationship was consistent with results from the within-subject analysis. For instance, each unit increase in sPINP between visit 2 and visit 1 was related to a subsequent decrease in femoral neck BMD of 0.6 ± 0.4 mg/cm2, but the relationship was not statistically significant (p = 0.18).

Bottom Line: However, neither baseline sPINP (p = 0.50) nor baseline sICTP (p = 0.63) was associated with subsequent changes in BMD.Moreover, changes in BMD were not significantly associated with previous changes in sPINP (p = 0.13) or sICTP (p = 0.95).However, neither sPINP nor sICTP was sufficiently sensitive to predict the rate of change in BMD for a group of individuals or for an individual.

View Article: PubMed Central - HTML - PubMed

Affiliation: Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia. t.nguyen@garvan.org.au

ABSTRACT

Background: It is not clear whether bone turnover markers can be used to make inference regarding changes in bone mineral density (BMD) in untreated healthy elderly men. The present study was designed to address three specific questions: (i) is there a relationship between bone turnover markers and femoral neck BMD within an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?

Methods: The present study was part of the on-going Dubbo Osteoporosis Epidemiology Study, which was designed as a prospective investigation. Men who had had at least 3 sequential visits with serum samples available during follow-up were selected from the study population. Serum C-terminal telopeptide of type I collagen (sICTP), N-terminal propeptide of type I collagen (sPINP) and femoral neck BMD were measured by competitive radioimmunoassays. Femoral neck bone mineral density (BMD) was measured by a densitometer (GE Lunar Corp, Madison, WI). Various mixed-effects models were used to assess the association between the markers and changes in BMD.

Results: One hundred and one men aged 70 +/- 4.1 years (mean +/- SD) met the criteria of selection for analysis. On average, sPINP decreased by 0.7% per year (p = 0.026), sICTP increased by 1.7% per year (p = 0.0002), and femoral neck BMD decreased by 0.4% per year (p < 0.01). Within-subject analysis indicated that changes in BMD were significantly associated with changes in sPINP (p = 0.022), but not with changes in sICTP (p = 0.84). However, neither baseline sPINP (p = 0.50) nor baseline sICTP (p = 0.63) was associated with subsequent changes in BMD. Moreover, changes in BMD were not significantly associated with previous changes in sPINP (p = 0.13) or sICTP (p = 0.95).

Conclusion: These results suggest that in elderly men of Caucasian background, changes in sPINP were inversely related to changes in BMD within an individual. However, neither sPINP nor sICTP was sufficiently sensitive to predict the rate of change in BMD for a group of individuals or for an individual.

Show MeSH
Related in: MedlinePlus