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Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region.

Pandey M, Rao LP, Das SR, Mathews A, Chacko EM, Naik BR - World J Surg Oncol (2007)

Bottom Line: The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible.Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%).Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram Kerala, India. manojpandey@vsnl.com

ABSTRACT

Background: Mandibular resections are routinely carried out for achieving a R0 resection for oral cancers. However, the need of mandibular resection to achieve this has always been questioned. The present study was carried out to define the pattern of mandibular involvement in carcinoma of the mandibular region.

Patients and methods: A total of 25 consecutive patients who had undergone mandibular resection and were found to have mandibular invasion were studied in a prospective open fashion. After decalcification the specimens were serially sectioned at 1 cm interval to identify invasion of mandibular bone. Type of invasion, route of spread and host cell reactions were also recorded.

Results: The mandibular involvement was infiltrative in 14(56%) and erosive in 11(44%). It was cortical in 5(20%), marrow involvement was seen in 15(60%) while 5(20%) had spread through the inferior alveolar canal. Of the 25, 24(96%) lesions were located with in 1 cm of the mandible.

Conclusion: The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible. Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%). Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement.

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Tumour invasion (T) into the perineural space of the inferior alveolar nerve bundles.
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Figure 3: Tumour invasion (T) into the perineural space of the inferior alveolar nerve bundles.

Mentions: The mean duration of symptoms was 3.9 ± 2.5 months while the mean depth of invasion was 2.08 ± 0.88 cm. The mandibular involvement was infiltrative in 14 (53%) (Figure 1) while it was erosive in 11(44%) (Figure 2). Pattern of mandibular involvement was characterised as cortical in 5(20%), involvement of bone marrow was seen in 15(60%) while 5(20%) had spread through the canal of inferior alveolar nerve with (Figure 3) or without invasion of inferior alveolar nerve (Figure 4). Depth of invasion was shallow in 8(32%), moderate in 7(28%) and deep in 10(40%). Among the patients who were previously irradiated 2 had perineural spread (2/6 33%), two patients showed subperiosteal fibrosis and one showed new bone formation while two patients had fatty marrow. Three patients each showed infiltrative and erosive pattern in this group.


Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region.

Pandey M, Rao LP, Das SR, Mathews A, Chacko EM, Naik BR - World J Surg Oncol (2007)

Tumour invasion (T) into the perineural space of the inferior alveolar nerve bundles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1803788&req=5

Figure 3: Tumour invasion (T) into the perineural space of the inferior alveolar nerve bundles.
Mentions: The mean duration of symptoms was 3.9 ± 2.5 months while the mean depth of invasion was 2.08 ± 0.88 cm. The mandibular involvement was infiltrative in 14 (53%) (Figure 1) while it was erosive in 11(44%) (Figure 2). Pattern of mandibular involvement was characterised as cortical in 5(20%), involvement of bone marrow was seen in 15(60%) while 5(20%) had spread through the canal of inferior alveolar nerve with (Figure 3) or without invasion of inferior alveolar nerve (Figure 4). Depth of invasion was shallow in 8(32%), moderate in 7(28%) and deep in 10(40%). Among the patients who were previously irradiated 2 had perineural spread (2/6 33%), two patients showed subperiosteal fibrosis and one showed new bone formation while two patients had fatty marrow. Three patients each showed infiltrative and erosive pattern in this group.

Bottom Line: The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible.Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%).Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram Kerala, India. manojpandey@vsnl.com

ABSTRACT

Background: Mandibular resections are routinely carried out for achieving a R0 resection for oral cancers. However, the need of mandibular resection to achieve this has always been questioned. The present study was carried out to define the pattern of mandibular involvement in carcinoma of the mandibular region.

Patients and methods: A total of 25 consecutive patients who had undergone mandibular resection and were found to have mandibular invasion were studied in a prospective open fashion. After decalcification the specimens were serially sectioned at 1 cm interval to identify invasion of mandibular bone. Type of invasion, route of spread and host cell reactions were also recorded.

Results: The mandibular involvement was infiltrative in 14(56%) and erosive in 11(44%). It was cortical in 5(20%), marrow involvement was seen in 15(60%) while 5(20%) had spread through the inferior alveolar canal. Of the 25, 24(96%) lesions were located with in 1 cm of the mandible.

Conclusion: The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible. Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%). Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement.

Show MeSH
Related in: MedlinePlus