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Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.

Deng GM, Tarkowski A - Arthritis Res. (2000)

Bottom Line: Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN).IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rheumatology, University of Göteborg, Göteborg, Sweden. guo-min@immuno.gu.se

ABSTRACT
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

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Related in: MedlinePlus

Expression of cytokine mRNA in synovial tissue from knees of IL-12 knockout mice (IL-12–/–) in comparison with their wild-type littermates (IL-12+/+), 3 d after intra-articular inoculation with 6 μg CpG ODN. Each bar represents the mean number and SEM of positive cells per mm2 in synovial tissue from four mice. NS = not significant.
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Figure 4: Expression of cytokine mRNA in synovial tissue from knees of IL-12 knockout mice (IL-12–/–) in comparison with their wild-type littermates (IL-12+/+), 3 d after intra-articular inoculation with 6 μg CpG ODN. Each bar represents the mean number and SEM of positive cells per mm2 in synovial tissue from four mice. NS = not significant.

Mentions: To explore how IL-12 influenced the CpG ODN-triggered arthritis, synovial tissues taken from the knees of wild-type and IL-12 knockout mice at day 3 after intra-articular inoculation with CpG ODN were evaluated for TNF-α, IL-1β, and IFN-γ mRNA expression using hybridization in situ. As shown in Fig. 4, the frequency of TNF-α and IL-1β mRNA expression in synovia was lower at day 3 in IL-12 knockout mice than in wild-type mice, and IFN-γ mRNA expression was undetectable.


Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.

Deng GM, Tarkowski A - Arthritis Res. (2000)

Expression of cytokine mRNA in synovial tissue from knees of IL-12 knockout mice (IL-12–/–) in comparison with their wild-type littermates (IL-12+/+), 3 d after intra-articular inoculation with 6 μg CpG ODN. Each bar represents the mean number and SEM of positive cells per mm2 in synovial tissue from four mice. NS = not significant.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC17824&req=5

Figure 4: Expression of cytokine mRNA in synovial tissue from knees of IL-12 knockout mice (IL-12–/–) in comparison with their wild-type littermates (IL-12+/+), 3 d after intra-articular inoculation with 6 μg CpG ODN. Each bar represents the mean number and SEM of positive cells per mm2 in synovial tissue from four mice. NS = not significant.
Mentions: To explore how IL-12 influenced the CpG ODN-triggered arthritis, synovial tissues taken from the knees of wild-type and IL-12 knockout mice at day 3 after intra-articular inoculation with CpG ODN were evaluated for TNF-α, IL-1β, and IFN-γ mRNA expression using hybridization in situ. As shown in Fig. 4, the frequency of TNF-α and IL-1β mRNA expression in synovia was lower at day 3 in IL-12 knockout mice than in wild-type mice, and IFN-γ mRNA expression was undetectable.

Bottom Line: Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN).IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rheumatology, University of Göteborg, Göteborg, Sweden. guo-min@immuno.gu.se

ABSTRACT
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

Show MeSH
Related in: MedlinePlus