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Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.

Deng GM, Tarkowski A - Arthritis Res. (2000)

Bottom Line: Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN).IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rheumatology, University of Göteborg, Göteborg, Sweden. guo-min@immuno.gu.se

ABSTRACT
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

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Related in: MedlinePlus

Incidence and severity of arthritis in knees of IL-12 knockout mice (IL-12–/–) (n = 8) in comparison with their wild-type littermates (IL-12+/+) (n = 9), 3 d after intra-articular inoculation with 6 μg CpG ODN. (a) Incidence. (b) Severity. NS = not significant.
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Figure 3: Incidence and severity of arthritis in knees of IL-12 knockout mice (IL-12–/–) (n = 8) in comparison with their wild-type littermates (IL-12+/+) (n = 9), 3 d after intra-articular inoculation with 6 μg CpG ODN. (a) Incidence. (b) Severity. NS = not significant.

Mentions: Since IL-12 mRNA expression was high during arthritis induced by CpG ODN, we studied its role further using IL-12 knockout mice. The incidence (62.5%) and severity (0.75 ± 0.75) of arthritis were decreased in IL-12 knockout mice as compared with their congenic littermates (100% and 1.33 ± 0.5, respectively) (Fig. 3a,b). These differences do not reach statistical significance.


Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.

Deng GM, Tarkowski A - Arthritis Res. (2000)

Incidence and severity of arthritis in knees of IL-12 knockout mice (IL-12–/–) (n = 8) in comparison with their wild-type littermates (IL-12+/+) (n = 9), 3 d after intra-articular inoculation with 6 μg CpG ODN. (a) Incidence. (b) Severity. NS = not significant.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC17824&req=5

Figure 3: Incidence and severity of arthritis in knees of IL-12 knockout mice (IL-12–/–) (n = 8) in comparison with their wild-type littermates (IL-12+/+) (n = 9), 3 d after intra-articular inoculation with 6 μg CpG ODN. (a) Incidence. (b) Severity. NS = not significant.
Mentions: Since IL-12 mRNA expression was high during arthritis induced by CpG ODN, we studied its role further using IL-12 knockout mice. The incidence (62.5%) and severity (0.75 ± 0.75) of arthritis were decreased in IL-12 knockout mice as compared with their congenic littermates (100% and 1.33 ± 0.5, respectively) (Fig. 3a,b). These differences do not reach statistical significance.

Bottom Line: Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN).IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rheumatology, University of Göteborg, Göteborg, Sweden. guo-min@immuno.gu.se

ABSTRACT
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

Show MeSH
Related in: MedlinePlus