Limits...
Municipal mortality due to thyroid cancer in Spain.

Lope V, Pollán M, Pérez-Gómez B, Aragonés N, Ramis R, Gómez-Barroso D, López-Abente G - BMC Public Health (2006)

Bottom Line: The observed mortality pattern coincides with areas in Spain where goiter has been declared endemic.The higher frequency in these same areas of undifferentiated, more aggressive carcinomas could be reflected in the mortality figures.Other unknown genetic or environmental factors could also play a role in the etiology of this tumor.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cancer and Environmental Epidemiology Area, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. vicarvajal@isciii.es

ABSTRACT

Background: Thyroid cancer is a tumor with a low but growing incidence in Spain. This study sought to depict its spatial municipal mortality pattern, using the classic model proposed by Besag, York and Mollié.

Methods: It was possible to compile and ascertain the posterior distribution of relative risk on the basis of a single Bayesian spatial model covering all of Spain's 8077 municipal areas. Maps were plotted depicting standardized mortality ratios, smoothed relative risk (RR) estimates, and the posterior probability that RR > 1.

Results: From 1989 to 1998 a total of 2,538 thyroid cancer deaths were registered in 1,041 municipalities. The highest relative risks were mostly situated in the Canary Islands, the province of Lugo, the east of La Coruña (Corunna) and western areas of Asturias and Orense.

Conclusion: The observed mortality pattern coincides with areas in Spain where goiter has been declared endemic. The higher frequency in these same areas of undifferentiated, more aggressive carcinomas could be reflected in the mortality figures. Other unknown genetic or environmental factors could also play a role in the etiology of this tumor.

Show MeSH

Related in: MedlinePlus

Municipal distribution of thyroid cancer mortality. Posterior probability of RR being greater than 1. Spain 1989–1998.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC1764886&req=5

Figure 3: Municipal distribution of thyroid cancer mortality. Posterior probability of RR being greater than 1. Spain 1989–1998.

Mentions: The SMRs are shown in Figure 1, the distribution of smoothed RRs for TC is plotted in Figure 2, and the posterior probability of RR being greater than 1 is depicted in Figure 3. The SMR map shows the polarization of the distribution towards its extremes (towns with and without cases), with no specific pattern being clearly discernable. The "noise" present in this map, deriving from the instability of the indicator, was eliminated by the smoothing procedure (Figure 2).


Municipal mortality due to thyroid cancer in Spain.

Lope V, Pollán M, Pérez-Gómez B, Aragonés N, Ramis R, Gómez-Barroso D, López-Abente G - BMC Public Health (2006)

Municipal distribution of thyroid cancer mortality. Posterior probability of RR being greater than 1. Spain 1989–1998.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1764886&req=5

Figure 3: Municipal distribution of thyroid cancer mortality. Posterior probability of RR being greater than 1. Spain 1989–1998.
Mentions: The SMRs are shown in Figure 1, the distribution of smoothed RRs for TC is plotted in Figure 2, and the posterior probability of RR being greater than 1 is depicted in Figure 3. The SMR map shows the polarization of the distribution towards its extremes (towns with and without cases), with no specific pattern being clearly discernable. The "noise" present in this map, deriving from the instability of the indicator, was eliminated by the smoothing procedure (Figure 2).

Bottom Line: The observed mortality pattern coincides with areas in Spain where goiter has been declared endemic.The higher frequency in these same areas of undifferentiated, more aggressive carcinomas could be reflected in the mortality figures.Other unknown genetic or environmental factors could also play a role in the etiology of this tumor.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cancer and Environmental Epidemiology Area, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. vicarvajal@isciii.es

ABSTRACT

Background: Thyroid cancer is a tumor with a low but growing incidence in Spain. This study sought to depict its spatial municipal mortality pattern, using the classic model proposed by Besag, York and Mollié.

Methods: It was possible to compile and ascertain the posterior distribution of relative risk on the basis of a single Bayesian spatial model covering all of Spain's 8077 municipal areas. Maps were plotted depicting standardized mortality ratios, smoothed relative risk (RR) estimates, and the posterior probability that RR > 1.

Results: From 1989 to 1998 a total of 2,538 thyroid cancer deaths were registered in 1,041 municipalities. The highest relative risks were mostly situated in the Canary Islands, the province of Lugo, the east of La Coruña (Corunna) and western areas of Asturias and Orense.

Conclusion: The observed mortality pattern coincides with areas in Spain where goiter has been declared endemic. The higher frequency in these same areas of undifferentiated, more aggressive carcinomas could be reflected in the mortality figures. Other unknown genetic or environmental factors could also play a role in the etiology of this tumor.

Show MeSH
Related in: MedlinePlus