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Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications.

Nayak BS, Roberts L - J Inflamm (Lond) (2006)

Bottom Line: Serum sialic acid concentrations were significantly higher among diabetic subjects (66.0 +/- 11.7 mg %) as compared to controls (55.2 +/- 8.3 mg %).The diabetic retinopathy patients also demonstrated significantly higher values of serum sialic acid (77.9 +/- 29.0) and urine microalbumin (351.1 +/- 559.9).Elevated serum sialic acid microalbumin concentrations were associated with cardiovascular risk factors such as hypertension, increased waist to hip ratios. (P < 0.05).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Preclinical Sciences, Biochemistry unit, The University of the West Indies, Trinidad. snayak@fms.uwi.tt

ABSTRACT

Background: Serum sialic acid and C reactive protein are the markers for inflammation. The main objective of this study was to determine the sialic acid level in Caribbean type 2 diabetic patients with and without microvascular complications and its relationship with metabolic and anthropometric variables.

Research design and methods: The Caribbean subjects aged 15-60 years with type 2 diabetes were recruited for the study. Fasting venous blood samples were collected from 162 subjects of which 44 were healthy individuals, 44 were of type 2 diabetes, 44 were of type 2 diabetes with nephropathy and 30 were of diabetes with retinopathy. Simultaneously urine samples were also collected from each of the subjects. All the blood samples were processed for lipid profile, glucose, HbA1C, C-reactive protein and sialic acid. The urine samples were analysed for sialic acid and microalbumin.

Results: Serum sialic acid concentrations were significantly higher among diabetic subjects (66.0 +/- 11.7 mg %) as compared to controls (55.2 +/- 8.3 mg %). There was a significantly increasing trend of serum sialic acid with severity of nephropathy (71.6 +/- 23.6 mg %) and degree of urinary albumin excretion (794.3 +/- 805.9). The diabetic retinopathy patients also demonstrated significantly higher values of serum sialic acid (77.9 +/- 29.0) and urine microalbumin (351.1 +/- 559.9). Elevated serum sialic acid microalbumin concentrations were associated with cardiovascular risk factors such as hypertension, increased waist to hip ratios. (P < 0.05). Sialic acid had no correlation with CRP or any component of the lipid profile.

Conclusion: The increased serum sialic acid and microalbumin were strongly related to the presence of microvascular complications like diabetic nephropathy and diabetic retinopathy and cardiovascular risk factors like hypertension and waist to hip ratios in Caribbean type-2 diabetic patients. The serum sialic acid may be used as an inflammatory marker and possible indicator of microvascular complications in type-2 diabetic patients.

No MeSH data available.


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Lipid profile status among the four study groups.
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Figure 2: Lipid profile status among the four study groups.

Mentions: Table 1 shows the relationship between inflammatory markers, metabolic and anthropometric variables in Caribbean population with type 2 diabetes mellitus. There is significant difference (p < 0.000) in serum sialic acid concentrations between at least two means, hence the hypothesis is rejected. Serum sialic acid concentrations were significantly higher among the diabetic subjects (66.0 ± 11.7 mg %) as compared to the controls (55.2 ± 8.3 mg %), (p < 0.01). Significant higher values of serum sialic acid were found among diabetic nephropathy (71.6 ± 23.6 mg %) and retinopathy (77.9 ± 29.0) subjects as compared to the controls (P < 0.000) (Figure 1). The waist/hip ratio of the diabetic (0.92 ± 0.07), diabetic nephropathy (0.94 ± 0.06) and diabetic retinopathy (0.93 ± 0.09) subjects were significantly higher than the controls (0.86 ± 0.06) (P < 0.000). The systolic blood pressure was significantly higher in diabetic (144.4 ± 20.5 mmHg), diabetic nephropathy (160.3 ± 28.0 mmHg) and diabetic retinopathy subjects (162.8 ± 25.60) when compared to the controls (123.9 ± 14.5 mmHg) (p < 0.000). Similarly, triglyceride concentrations were significantly higher among diabetics (155.4 ± 114.8 mg/dl), diabetic nephropathy (149.4 ± 75.8) and diabetic retinopathy (176.5 ± 93.2) subjects as compared to controls (105.7 ± 65.1 mg/dl), however the diabetics with nephropathy showed moderate increase in triglycerides when compared to the controls. There was not much difference in the LDL values among the groups. The figure 2 explains the lipid profile status among the four study groups. It was found that there were significant increases in fasting blood glucose, urinary albumin and HbA1c among diabetics (p < 0.05). There was no significant change in the concentrations of C reactive protein, urinary sialic acid, HDL, VLDL, cholesterol and BMI between the four study groups. Serum sialic acid was significantly correlated with urine microalbumin (r = 0.484, p < 0.01), waist/hip ratio(r = 0.226, P < 0.05) and systolic blood pressure(r = .263, P < 0.01) Figures 3 and 4 represents the correlation of sialic acid with waist/hip ratio and systolic blood pressure respectively


Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications.

Nayak BS, Roberts L - J Inflamm (Lond) (2006)

Lipid profile status among the four study groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1764741&req=5

Figure 2: Lipid profile status among the four study groups.
Mentions: Table 1 shows the relationship between inflammatory markers, metabolic and anthropometric variables in Caribbean population with type 2 diabetes mellitus. There is significant difference (p < 0.000) in serum sialic acid concentrations between at least two means, hence the hypothesis is rejected. Serum sialic acid concentrations were significantly higher among the diabetic subjects (66.0 ± 11.7 mg %) as compared to the controls (55.2 ± 8.3 mg %), (p < 0.01). Significant higher values of serum sialic acid were found among diabetic nephropathy (71.6 ± 23.6 mg %) and retinopathy (77.9 ± 29.0) subjects as compared to the controls (P < 0.000) (Figure 1). The waist/hip ratio of the diabetic (0.92 ± 0.07), diabetic nephropathy (0.94 ± 0.06) and diabetic retinopathy (0.93 ± 0.09) subjects were significantly higher than the controls (0.86 ± 0.06) (P < 0.000). The systolic blood pressure was significantly higher in diabetic (144.4 ± 20.5 mmHg), diabetic nephropathy (160.3 ± 28.0 mmHg) and diabetic retinopathy subjects (162.8 ± 25.60) when compared to the controls (123.9 ± 14.5 mmHg) (p < 0.000). Similarly, triglyceride concentrations were significantly higher among diabetics (155.4 ± 114.8 mg/dl), diabetic nephropathy (149.4 ± 75.8) and diabetic retinopathy (176.5 ± 93.2) subjects as compared to controls (105.7 ± 65.1 mg/dl), however the diabetics with nephropathy showed moderate increase in triglycerides when compared to the controls. There was not much difference in the LDL values among the groups. The figure 2 explains the lipid profile status among the four study groups. It was found that there were significant increases in fasting blood glucose, urinary albumin and HbA1c among diabetics (p < 0.05). There was no significant change in the concentrations of C reactive protein, urinary sialic acid, HDL, VLDL, cholesterol and BMI between the four study groups. Serum sialic acid was significantly correlated with urine microalbumin (r = 0.484, p < 0.01), waist/hip ratio(r = 0.226, P < 0.05) and systolic blood pressure(r = .263, P < 0.01) Figures 3 and 4 represents the correlation of sialic acid with waist/hip ratio and systolic blood pressure respectively

Bottom Line: Serum sialic acid concentrations were significantly higher among diabetic subjects (66.0 +/- 11.7 mg %) as compared to controls (55.2 +/- 8.3 mg %).The diabetic retinopathy patients also demonstrated significantly higher values of serum sialic acid (77.9 +/- 29.0) and urine microalbumin (351.1 +/- 559.9).Elevated serum sialic acid microalbumin concentrations were associated with cardiovascular risk factors such as hypertension, increased waist to hip ratios. (P < 0.05).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Preclinical Sciences, Biochemistry unit, The University of the West Indies, Trinidad. snayak@fms.uwi.tt

ABSTRACT

Background: Serum sialic acid and C reactive protein are the markers for inflammation. The main objective of this study was to determine the sialic acid level in Caribbean type 2 diabetic patients with and without microvascular complications and its relationship with metabolic and anthropometric variables.

Research design and methods: The Caribbean subjects aged 15-60 years with type 2 diabetes were recruited for the study. Fasting venous blood samples were collected from 162 subjects of which 44 were healthy individuals, 44 were of type 2 diabetes, 44 were of type 2 diabetes with nephropathy and 30 were of diabetes with retinopathy. Simultaneously urine samples were also collected from each of the subjects. All the blood samples were processed for lipid profile, glucose, HbA1C, C-reactive protein and sialic acid. The urine samples were analysed for sialic acid and microalbumin.

Results: Serum sialic acid concentrations were significantly higher among diabetic subjects (66.0 +/- 11.7 mg %) as compared to controls (55.2 +/- 8.3 mg %). There was a significantly increasing trend of serum sialic acid with severity of nephropathy (71.6 +/- 23.6 mg %) and degree of urinary albumin excretion (794.3 +/- 805.9). The diabetic retinopathy patients also demonstrated significantly higher values of serum sialic acid (77.9 +/- 29.0) and urine microalbumin (351.1 +/- 559.9). Elevated serum sialic acid microalbumin concentrations were associated with cardiovascular risk factors such as hypertension, increased waist to hip ratios. (P < 0.05). Sialic acid had no correlation with CRP or any component of the lipid profile.

Conclusion: The increased serum sialic acid and microalbumin were strongly related to the presence of microvascular complications like diabetic nephropathy and diabetic retinopathy and cardiovascular risk factors like hypertension and waist to hip ratios in Caribbean type-2 diabetic patients. The serum sialic acid may be used as an inflammatory marker and possible indicator of microvascular complications in type-2 diabetic patients.

No MeSH data available.


Related in: MedlinePlus