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PharmGED: Pharmacogenetic Effect Database.

Zheng CJ, Han LY, Xie B, Liew CY, Ong S, Cui J, Zhang HL, Tang ZQ, Gan SH, Jiang L, Chen YZ - Nucleic Acids Res. (2006)

Bottom Line: Although databases of pharmacogenetic knowledge, polymorphism and toxicogenomic information have appeared, some of the relevant data are provided in separate web-pages and in terms of relatively long descriptions quoted from literatures.To facilitate easy and quick assessment of the relevant information, it is helpful to develop databases that provide all of the information related to a pharmacogenetic effect in the same web-page and in brief descriptions.We developed a database, Pharmacogenetic Effect Database (PharmGED), for providing sequence, function, polymorphism, affected drugs and pharmacogenetic effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Bioinformatics and Drug Design Group, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, Singapore 117543.

ABSTRACT
Prediction and elucidation of pharmacogenetic effects is important for facilitating the development of personalized medicines. Knowledge of polymorphism-induced and other types of drug-response variations is needed for facilitating such studies. Although databases of pharmacogenetic knowledge, polymorphism and toxicogenomic information have appeared, some of the relevant data are provided in separate web-pages and in terms of relatively long descriptions quoted from literatures. To facilitate easy and quick assessment of the relevant information, it is helpful to develop databases that provide all of the information related to a pharmacogenetic effect in the same web-page and in brief descriptions. We developed a database, Pharmacogenetic Effect Database (PharmGED), for providing sequence, function, polymorphism, affected drugs and pharmacogenetic effects. PharmGED can be accessed at http://bidd.cz3.nus.edu.sg/phg/ free of charge for academic use. It currently contains 1825 entries covering 108 disease conditions, 266 distinct proteins, 693 polymorphisms, 414 drugs/ligands cited from 856 references.

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Related in: MedlinePlus

Interface displaying the detailed information of an entry in PharmGED.
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fig2: Interface displaying the detailed information of an entry in PharmGED.

Mentions: The result of a typical search is illustrated in Figure 1. In this interface, all entries that satisfy the specified search criteria are listed along with protein name, polymorphism rules, drug/ligand name, drug classification, disease name and links to other related entries in this database. More detailed information of an entry can be obtained by clicking the corresponding protein name. The result is displayed in an interface shown in Figure 2. From this interface, one finds the accession number, name, sequence and function of protein, pharmacogenetic polymorphism, affected drugs and drug class, corresponding disease condition and pharmacogenetic effect. Moreover, the information about the related references and links to the literature database PUBMED (22) is also provided.


PharmGED: Pharmacogenetic Effect Database.

Zheng CJ, Han LY, Xie B, Liew CY, Ong S, Cui J, Zhang HL, Tang ZQ, Gan SH, Jiang L, Chen YZ - Nucleic Acids Res. (2006)

Interface displaying the detailed information of an entry in PharmGED.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1761431&req=5

fig2: Interface displaying the detailed information of an entry in PharmGED.
Mentions: The result of a typical search is illustrated in Figure 1. In this interface, all entries that satisfy the specified search criteria are listed along with protein name, polymorphism rules, drug/ligand name, drug classification, disease name and links to other related entries in this database. More detailed information of an entry can be obtained by clicking the corresponding protein name. The result is displayed in an interface shown in Figure 2. From this interface, one finds the accession number, name, sequence and function of protein, pharmacogenetic polymorphism, affected drugs and drug class, corresponding disease condition and pharmacogenetic effect. Moreover, the information about the related references and links to the literature database PUBMED (22) is also provided.

Bottom Line: Although databases of pharmacogenetic knowledge, polymorphism and toxicogenomic information have appeared, some of the relevant data are provided in separate web-pages and in terms of relatively long descriptions quoted from literatures.To facilitate easy and quick assessment of the relevant information, it is helpful to develop databases that provide all of the information related to a pharmacogenetic effect in the same web-page and in brief descriptions.We developed a database, Pharmacogenetic Effect Database (PharmGED), for providing sequence, function, polymorphism, affected drugs and pharmacogenetic effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Bioinformatics and Drug Design Group, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, Singapore 117543.

ABSTRACT
Prediction and elucidation of pharmacogenetic effects is important for facilitating the development of personalized medicines. Knowledge of polymorphism-induced and other types of drug-response variations is needed for facilitating such studies. Although databases of pharmacogenetic knowledge, polymorphism and toxicogenomic information have appeared, some of the relevant data are provided in separate web-pages and in terms of relatively long descriptions quoted from literatures. To facilitate easy and quick assessment of the relevant information, it is helpful to develop databases that provide all of the information related to a pharmacogenetic effect in the same web-page and in brief descriptions. We developed a database, Pharmacogenetic Effect Database (PharmGED), for providing sequence, function, polymorphism, affected drugs and pharmacogenetic effects. PharmGED can be accessed at http://bidd.cz3.nus.edu.sg/phg/ free of charge for academic use. It currently contains 1825 entries covering 108 disease conditions, 266 distinct proteins, 693 polymorphisms, 414 drugs/ligands cited from 856 references.

Show MeSH
Related in: MedlinePlus