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Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions.

Adams JD, Wang R, Yang J, Lien EJ - Chin Med (2006)

Bottom Line: Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries.Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities.Meta-analyses of S. miltiorrhiza are also discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA. jadams@usc.edu

ABSTRACT
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina pectoris, stroke and some other conditions. The use of S. miltiorrhiza has been increasing in the management of stroke. Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities. This review discusses the pharmacology, medicinal chemistry and clinical studies published, especially in China, for danshen and tanshinone preparations. Clinical examinations are evaluated in terms of S. miltiorrhiza preparation, dose, double blinding, control, clinical assessments of outcomes and other parameters. Meta-analyses of S. miltiorrhiza are also discussed.

No MeSH data available.


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Danshensu and monoterpenoids from S. miltiorrhiza. All of these compounds contain catechol functionalities.
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Figure 4: Danshensu and monoterpenoids from S. miltiorrhiza. All of these compounds contain catechol functionalities.

Mentions: Salvianolic acids in S. miltiorrhiza appear to be synthesized from monoterpenoids such as danshensu (Figure 4). Acetylsalvianolic acid A, a semi-synthetic derivative of salvianolic acid from S. miltiorrhiza is neuroprotective in middle cerebral artery thrombosis [43] and inhibits platelet aggregation [44]. Salvianolic acids (Figure 5) from S. miltiorrhiza increase cerebral blood flow after ischemia [45]. Salvianolic acid A is protective against cerebral and myocardial ischemia and reperfusion [46]. Lithospermic acid B (Figure 6), also called tanshinoate B or salvianolic acid B, increases NO production by endothelial cells [47] and inhibits ACE [6]. NO is a vasorelaxant that should bring down local blood pressure. Lithospermic acid B is antihypertensive and is protective against cerebral and myocardial ischemia and reperfusion [46]. Rosmarinic acid and salvianolic acids in S. miltiorrhiza inhibit thrombosis, thromboxane B2 formation and platelet aggregation [45,46].


Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions.

Adams JD, Wang R, Yang J, Lien EJ - Chin Med (2006)

Danshensu and monoterpenoids from S. miltiorrhiza. All of these compounds contain catechol functionalities.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1761145&req=5

Figure 4: Danshensu and monoterpenoids from S. miltiorrhiza. All of these compounds contain catechol functionalities.
Mentions: Salvianolic acids in S. miltiorrhiza appear to be synthesized from monoterpenoids such as danshensu (Figure 4). Acetylsalvianolic acid A, a semi-synthetic derivative of salvianolic acid from S. miltiorrhiza is neuroprotective in middle cerebral artery thrombosis [43] and inhibits platelet aggregation [44]. Salvianolic acids (Figure 5) from S. miltiorrhiza increase cerebral blood flow after ischemia [45]. Salvianolic acid A is protective against cerebral and myocardial ischemia and reperfusion [46]. Lithospermic acid B (Figure 6), also called tanshinoate B or salvianolic acid B, increases NO production by endothelial cells [47] and inhibits ACE [6]. NO is a vasorelaxant that should bring down local blood pressure. Lithospermic acid B is antihypertensive and is protective against cerebral and myocardial ischemia and reperfusion [46]. Rosmarinic acid and salvianolic acids in S. miltiorrhiza inhibit thrombosis, thromboxane B2 formation and platelet aggregation [45,46].

Bottom Line: Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries.Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities.Meta-analyses of S. miltiorrhiza are also discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA. jadams@usc.edu

ABSTRACT
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina pectoris, stroke and some other conditions. The use of S. miltiorrhiza has been increasing in the management of stroke. Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities. This review discusses the pharmacology, medicinal chemistry and clinical studies published, especially in China, for danshen and tanshinone preparations. Clinical examinations are evaluated in terms of S. miltiorrhiza preparation, dose, double blinding, control, clinical assessments of outcomes and other parameters. Meta-analyses of S. miltiorrhiza are also discussed.

No MeSH data available.


Related in: MedlinePlus