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Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays.

Tinwell H, Soames AR, Foster JR, Ashby J - Environ. Health Perspect. (2000)

Bottom Line: Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content.We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding increases in uterine epithelial cell height, glandular formation, cell labeling, and DNA content.We concluded that the uterotrophic activity of coumestrol is typical of the natural estrogen estradiol.

View Article: PubMed Central - PubMed

Affiliation: Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom.

ABSTRACT
Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content. We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding increases in uterine epithelial cell height, glandular formation, cell labeling, and DNA content. These papers did not answer the question of whether there is a basic difference between the ovariectomized and the intact rat uterotrophic assays. In this paper, we report that coumestrol gives a typical estradiol-type uterotrophic response in uterotrophic assays using immature intact, immature ovariectomized, and mature ovariectomized rats. We concluded that the uterotrophic activity of coumestrol is typical of the natural estrogen estradiol.

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Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays.

Tinwell H, Soames AR, Foster JR, Ashby J - Environ. Health Perspect. (2000)

© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC1638188&req=5

Bottom Line: Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content.We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding increases in uterine epithelial cell height, glandular formation, cell labeling, and DNA content.We concluded that the uterotrophic activity of coumestrol is typical of the natural estrogen estradiol.

View Article: PubMed Central - PubMed

Affiliation: Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom.

ABSTRACT
Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content. We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding increases in uterine epithelial cell height, glandular formation, cell labeling, and DNA content. These papers did not answer the question of whether there is a basic difference between the ovariectomized and the intact rat uterotrophic assays. In this paper, we report that coumestrol gives a typical estradiol-type uterotrophic response in uterotrophic assays using immature intact, immature ovariectomized, and mature ovariectomized rats. We concluded that the uterotrophic activity of coumestrol is typical of the natural estrogen estradiol.

Show MeSH
Related in: MedlinePlus