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Levels of methyleugenol in a subset of adults in the general U.S. population as determined by high resolution mass spectrometry.

Barr DB, Barr JR, Bailey SL, Lapeza CR, Beeson MD, Caudill SP, Maggio VL, Schecter A, Masten SA, Lucier GW, Needham LL, Sampson EJ - Environ. Health Perspect. (2000)

Bottom Line: Lipid adjustment of the data did not alter the distribution.Although no demographic variable was a good predictor of ME exposure or dose, our data indicate prevalent exposure of U.S. adults to ME.Detailed pharmacokinetic studies are required to determine the relationship between ME intake and human serum ME concentrations.

View Article: PubMed Central - PubMed

Affiliation: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. dlb1@cdc.gov

ABSTRACT
We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detection is 3.1 pg/g and its average coefficient of variation is 14% over a 200-pg/g range. We applied this method to measure serum ME concentrations in adults in the general U.S. population. ME was detected in 98% of our samples, with a mean ME concentration of 24 pg/g (range < 3.1-390 pg/g). Lipid adjustment of the data did not alter the distribution. Bivariate and multivariate analyses using selected demographic variables showed only marginal relationships between race/ethnicity and sex/fasting status with serum ME concentrations. Although no demographic variable was a good predictor of ME exposure or dose, our data indicate prevalent exposure of U.S. adults to ME. Detailed pharmacokinetic studies are required to determine the relationship between ME intake and human serum ME concentrations.

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Levels of methyleugenol in a subset of adults in the general U.S. population as determined by high resolution mass spectrometry.

Barr DB, Barr JR, Bailey SL, Lapeza CR, Beeson MD, Caudill SP, Maggio VL, Schecter A, Masten SA, Lucier GW, Needham LL, Sampson EJ - Environ. Health Perspect. (2000)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1638031&req=5

Bottom Line: Lipid adjustment of the data did not alter the distribution.Although no demographic variable was a good predictor of ME exposure or dose, our data indicate prevalent exposure of U.S. adults to ME.Detailed pharmacokinetic studies are required to determine the relationship between ME intake and human serum ME concentrations.

View Article: PubMed Central - PubMed

Affiliation: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. dlb1@cdc.gov

ABSTRACT
We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detection is 3.1 pg/g and its average coefficient of variation is 14% over a 200-pg/g range. We applied this method to measure serum ME concentrations in adults in the general U.S. population. ME was detected in 98% of our samples, with a mean ME concentration of 24 pg/g (range < 3.1-390 pg/g). Lipid adjustment of the data did not alter the distribution. Bivariate and multivariate analyses using selected demographic variables showed only marginal relationships between race/ethnicity and sex/fasting status with serum ME concentrations. Although no demographic variable was a good predictor of ME exposure or dose, our data indicate prevalent exposure of U.S. adults to ME. Detailed pharmacokinetic studies are required to determine the relationship between ME intake and human serum ME concentrations.

Show MeSH
Related in: MedlinePlus