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Study of the combined action of a group of chlorine derivatives of hydrocarbons entering the organism by inhalation.

Sidorenko GI, Tsulaya VR, Bonashevskaya TI, Shaĭpak VM - Environ. Health Perspect. (1979)

Bottom Line: Since a correct assessment of the combined action of substances is based on the comparison of the effect of mixed compounds and the effects observed for each component alone, research was conducted on each individual substances on the basis of the "concentration--time" relationship.The reaction of several mixtures of substances was also studied at various concentration levels, from high to low concentration levels of substances which are actually present in the atmosphere.Research result showed that the character of the mixture at both high and low levels of concentration was identical and approximate to the overall effects.

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ABSTRACT
The combined action of substances having a munidirectional toxic effect on the organism was studied for several typical chlorine derivatives of hydrocarbons (1,2-dichloropropane, 1,2,3,-trichloropropane, and perchloroethylene). Since a correct assessment of the combined action of substances is based on the comparison of the effect of mixed compounds and the effects observed for each component alone, research was conducted on each individual substances on the basis of the "concentration--time" relationship. The reaction of several mixtures of substances was also studied at various concentration levels, from high to low concentration levels of substances which are actually present in the atmosphere. Research result showed that the character of the mixture at both high and low levels of concentration was identical and approximate to the overall effects.

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Study of the combined action of a group of chlorine derivatives of hydrocarbons entering the organism by inhalation.

Sidorenko GI, Tsulaya VR, Bonashevskaya TI, Shaĭpak VM - Environ. Health Perspect. (1979)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1637697&req=5

Bottom Line: Since a correct assessment of the combined action of substances is based on the comparison of the effect of mixed compounds and the effects observed for each component alone, research was conducted on each individual substances on the basis of the "concentration--time" relationship.The reaction of several mixtures of substances was also studied at various concentration levels, from high to low concentration levels of substances which are actually present in the atmosphere.Research result showed that the character of the mixture at both high and low levels of concentration was identical and approximate to the overall effects.

View Article: PubMed Central - PubMed

ABSTRACT
The combined action of substances having a munidirectional toxic effect on the organism was studied for several typical chlorine derivatives of hydrocarbons (1,2-dichloropropane, 1,2,3,-trichloropropane, and perchloroethylene). Since a correct assessment of the combined action of substances is based on the comparison of the effect of mixed compounds and the effects observed for each component alone, research was conducted on each individual substances on the basis of the "concentration--time" relationship. The reaction of several mixtures of substances was also studied at various concentration levels, from high to low concentration levels of substances which are actually present in the atmosphere. Research result showed that the character of the mixture at both high and low levels of concentration was identical and approximate to the overall effects.

Show MeSH
Related in: MedlinePlus