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Effects of brain polarization on reaction times and pinch force in chronic stroke.

Hummel FC, Voller B, Celnik P, Floel A, Giraux P, Gerloff C, Cohen LG - BMC Neurosci (2006)

Bottom Line: Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL).It is not known if relatively simpler motor tasks are similarly affected.Anodal tDCS shortened reaction times and improved pinch force in the paretic hand relative to Sham stimulation, an effect present in patients with higher impairment. tDCS of M1affected hemisphere can modulate performance of motor tasks simpler than those previously studied, a finding that could potentially benefit patients with relatively higher impairment levels.

View Article: PubMed Central - HTML - PubMed

Affiliation: Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. f.hummel@uke.uni-hamburg.de <f.hummel@uke.uni-hamburg.de>

ABSTRACT

Background: Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively simpler motor tasks are similarly affected. Here we tested the effects of tDCS on pinch force (PF) and simple reaction time (RT) tasks in patients with chronic stroke in a double-blind cross-over Sham-controlled experimental design.

Results: Anodal tDCS shortened reaction times and improved pinch force in the paretic hand relative to Sham stimulation, an effect present in patients with higher impairment.

Conclusion: tDCS of M1affected hemisphere can modulate performance of motor tasks simpler than those previously studied, a finding that could potentially benefit patients with relatively higher impairment levels.

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Related in: MedlinePlus

Effects of tDCS and impairment of patients. Patients were stratified in two groups according to their ability to perform skilled ADL-like motor tasks. Less impaired patients (n = 7) were able to perform the Jebsen-Taylor-Task (JTT) and more impaired patients were not able to perform the JTT. After stratification tDCS-induced improvement of reaction time (A) and pinch force (B) was calculated for each group. Note, that the improvement was larger in the more impaired group.
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Figure 2: Effects of tDCS and impairment of patients. Patients were stratified in two groups according to their ability to perform skilled ADL-like motor tasks. Less impaired patients (n = 7) were able to perform the Jebsen-Taylor-Task (JTT) and more impaired patients were not able to perform the JTT. After stratification tDCS-induced improvement of reaction time (A) and pinch force (B) was calculated for each group. Note, that the improvement was larger in the more impaired group.

Mentions: Stratification of patients according to impairment levels revealed that tDCS-induced improvement was more pronounced in the more impaired group (RT = 15.0 ± 3.2%; Fig. 2A) compared to the less impaired group (RT = 8.9 ± 3.1%; Fig. 2A). Correlation analyses showed a nonsignificant trend for more prominent tDCS-induced improvement in RT in patients with lower MRC scores (Spearman's rho [two tailed] R2 = 0.36; p = 0.06)


Effects of brain polarization on reaction times and pinch force in chronic stroke.

Hummel FC, Voller B, Celnik P, Floel A, Giraux P, Gerloff C, Cohen LG - BMC Neurosci (2006)

Effects of tDCS and impairment of patients. Patients were stratified in two groups according to their ability to perform skilled ADL-like motor tasks. Less impaired patients (n = 7) were able to perform the Jebsen-Taylor-Task (JTT) and more impaired patients were not able to perform the JTT. After stratification tDCS-induced improvement of reaction time (A) and pinch force (B) was calculated for each group. Note, that the improvement was larger in the more impaired group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1636653&req=5

Figure 2: Effects of tDCS and impairment of patients. Patients were stratified in two groups according to their ability to perform skilled ADL-like motor tasks. Less impaired patients (n = 7) were able to perform the Jebsen-Taylor-Task (JTT) and more impaired patients were not able to perform the JTT. After stratification tDCS-induced improvement of reaction time (A) and pinch force (B) was calculated for each group. Note, that the improvement was larger in the more impaired group.
Mentions: Stratification of patients according to impairment levels revealed that tDCS-induced improvement was more pronounced in the more impaired group (RT = 15.0 ± 3.2%; Fig. 2A) compared to the less impaired group (RT = 8.9 ± 3.1%; Fig. 2A). Correlation analyses showed a nonsignificant trend for more prominent tDCS-induced improvement in RT in patients with lower MRC scores (Spearman's rho [two tailed] R2 = 0.36; p = 0.06)

Bottom Line: Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL).It is not known if relatively simpler motor tasks are similarly affected.Anodal tDCS shortened reaction times and improved pinch force in the paretic hand relative to Sham stimulation, an effect present in patients with higher impairment. tDCS of M1affected hemisphere can modulate performance of motor tasks simpler than those previously studied, a finding that could potentially benefit patients with relatively higher impairment levels.

View Article: PubMed Central - HTML - PubMed

Affiliation: Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. f.hummel@uke.uni-hamburg.de <f.hummel@uke.uni-hamburg.de>

ABSTRACT

Background: Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively simpler motor tasks are similarly affected. Here we tested the effects of tDCS on pinch force (PF) and simple reaction time (RT) tasks in patients with chronic stroke in a double-blind cross-over Sham-controlled experimental design.

Results: Anodal tDCS shortened reaction times and improved pinch force in the paretic hand relative to Sham stimulation, an effect present in patients with higher impairment.

Conclusion: tDCS of M1affected hemisphere can modulate performance of motor tasks simpler than those previously studied, a finding that could potentially benefit patients with relatively higher impairment levels.

Show MeSH
Related in: MedlinePlus