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Increased susceptibility to metabolic alterations in young adult females exposed to early malnutrition.

Miñana-Solis Mdel C, Escobar C - Int. J. Biol. Sci. (2006)

Bottom Line: Deleterious effects have mainly been observed when early-malnutrition is followed by a high-carbohydrate or a high-fat diet.Males under ad libitum conditions showed an elevated concentration of hepatic glycogen and low values of insulin.In the fasting-reefed satiated condition, only early-malnourished females showed an alteration in glucose response and glucagon level, compared with their well-nourished controls.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF 04510.

ABSTRACT
Early malnutrition during gestation and lactation modifies growth and metabolism permanently. Follow up studies using a nutritional rehabilitation protocol have reported that early malnourished rats exhibit hyperglycemia and/or hyperinsulinemia, suggesting that the effects of early malnutrition are permanent and produce a "programming" effect on metabolism. Deleterious effects have mainly been observed when early-malnutrition is followed by a high-carbohydrate or a high-fat diet. The aim of this study was to evaluate whether following a balanced diet subsequent to malnutrition can deter the expression of metabolic disease and lead rats to exhibit metabolic responses, similar to those of well-nourished controls. Young rats, born from dams malnourished during gestation and lactation with a low protein diet, were provided with a regular balanced chow diet upon weaning. At 90 days of age, the effects of rehabilitation were determined under three different feeding conditions: ad libitum, fasting or fasting-reefed satiated.Early-malnourished rats showed an increased rate of body weight gain. Males under ad libitum conditions showed an elevated concentration of hepatic glycogen and low values of insulin. In the fasting-reefed satiated condition, only early-malnourished females showed an alteration in glucose response and glucagon level, compared with their well-nourished controls. Data indicate that a balanced diet along life after early malnutrition can mask the expression of metabolic disorders and that a metabolic challenges due to a prolonged fasting and reefed state unmask metabolic deficiencies in early-malnourished females.

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Plasma concentration of insulin (A), glucagon (B) and insulin/glucagon ratio (C). There were differences within metabolic conditions (•) F ≠ al, F≠ S and al ≠ S (p<0.001) and (*) between groups C ≠ E-M (p<0.04). For other details see fig 2.
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Figure 4: Plasma concentration of insulin (A), glucagon (B) and insulin/glucagon ratio (C). There were differences within metabolic conditions (•) F ≠ al, F≠ S and al ≠ S (p<0.001) and (*) between groups C ≠ E-M (p<0.04). For other details see fig 2.

Mentions: The general pattern of insulin secretion was similar for the different nutritional groups. As expected, initial concentration observed in Cal and E-Mal, decreased in CF and E-MF and increased in CS and E-MS. Cal males exhibited higher insulin levels than the E-Mal males and than the Cal females (Figure 4A).


Increased susceptibility to metabolic alterations in young adult females exposed to early malnutrition.

Miñana-Solis Mdel C, Escobar C - Int. J. Biol. Sci. (2006)

Plasma concentration of insulin (A), glucagon (B) and insulin/glucagon ratio (C). There were differences within metabolic conditions (•) F ≠ al, F≠ S and al ≠ S (p<0.001) and (*) between groups C ≠ E-M (p<0.04). For other details see fig 2.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1622891&req=5

Figure 4: Plasma concentration of insulin (A), glucagon (B) and insulin/glucagon ratio (C). There were differences within metabolic conditions (•) F ≠ al, F≠ S and al ≠ S (p<0.001) and (*) between groups C ≠ E-M (p<0.04). For other details see fig 2.
Mentions: The general pattern of insulin secretion was similar for the different nutritional groups. As expected, initial concentration observed in Cal and E-Mal, decreased in CF and E-MF and increased in CS and E-MS. Cal males exhibited higher insulin levels than the E-Mal males and than the Cal females (Figure 4A).

Bottom Line: Deleterious effects have mainly been observed when early-malnutrition is followed by a high-carbohydrate or a high-fat diet.Males under ad libitum conditions showed an elevated concentration of hepatic glycogen and low values of insulin.In the fasting-reefed satiated condition, only early-malnourished females showed an alteration in glucose response and glucagon level, compared with their well-nourished controls.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF 04510.

ABSTRACT
Early malnutrition during gestation and lactation modifies growth and metabolism permanently. Follow up studies using a nutritional rehabilitation protocol have reported that early malnourished rats exhibit hyperglycemia and/or hyperinsulinemia, suggesting that the effects of early malnutrition are permanent and produce a "programming" effect on metabolism. Deleterious effects have mainly been observed when early-malnutrition is followed by a high-carbohydrate or a high-fat diet. The aim of this study was to evaluate whether following a balanced diet subsequent to malnutrition can deter the expression of metabolic disease and lead rats to exhibit metabolic responses, similar to those of well-nourished controls. Young rats, born from dams malnourished during gestation and lactation with a low protein diet, were provided with a regular balanced chow diet upon weaning. At 90 days of age, the effects of rehabilitation were determined under three different feeding conditions: ad libitum, fasting or fasting-reefed satiated.Early-malnourished rats showed an increased rate of body weight gain. Males under ad libitum conditions showed an elevated concentration of hepatic glycogen and low values of insulin. In the fasting-reefed satiated condition, only early-malnourished females showed an alteration in glucose response and glucagon level, compared with their well-nourished controls. Data indicate that a balanced diet along life after early malnutrition can mask the expression of metabolic disorders and that a metabolic challenges due to a prolonged fasting and reefed state unmask metabolic deficiencies in early-malnourished females.

Show MeSH
Related in: MedlinePlus