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Mapping of lymphatic filariasis in Nepal.

Sherchand JB, Obsomer V, Thakur GD, Hommel M - Filaria J (2003)

Bottom Line: RESULTS: The overall prevalence of lymphatic filariasis from a 4,488-sample population was 13% and 33/37 districts were found to be endemic.On the basis of geographical data, the highest number of cases was found at altitudes between 500-700 m; however, a substantial number of infected individuals were found in the highly populated Kathmandu valley, at altitudes between 900-1,500 metres where transmission appears to take place.The study indicates that the prevalence of infection is far greater that was previously reported and that lymphatic filariasis should be a much higher health priority than currently given.

View Article: PubMed Central - HTML - PubMed

Affiliation: Liverpool School of Tropical Medicine, Disease Control Strategy Group, Pembroke Place L3 5QA, Liverpool, United Kingdom. mhommel@liv.ac.uk

ABSTRACT
BACKGROUND: Human infection with Wuchereria bancrofti causes a disabling parasitic disease known as lymphatic filariasis, which is a major public health and socio-economic problem in many parts of the world. At the onset of the study, little was known of the distribution of filariasis and its current importance as a public health problem in Nepal. METHODS: Epidemiological mapping was undertaken to determine the prevalence of infection by Wuchereria bancrofti in 37 districts of Nepal between July to December 2001. The study population above 15 years of age was selected, and the immunochromatographic test (ICT Filariasis) was used to screen for circulating filarial antigen (CFA). RESULTS: The overall prevalence of lymphatic filariasis from a 4,488-sample population was 13% and 33/37 districts were found to be endemic. On the basis of geographical data, the highest number of cases was found at altitudes between 500-700 m; however, a substantial number of infected individuals were found in the highly populated Kathmandu valley, at altitudes between 900-1,500 metres where transmission appears to take place. Prevalence rates above 20% were found in 11 districts (with the highest rate of 40%), 6-19% were found in 15 districts, and 0.1-5% were in 7 districts.Information on people's knowledge, attitudes and behaviour towards filariasis was also collected by means of a structured questionnaire, which is presented and discussed in the study. CONCLUSIONS: This is the most extensive study of lymphatic filariasis undertaken to date in Nepal. The study indicates that the prevalence of infection is far greater that was previously reported and that lymphatic filariasis should be a much higher health priority than currently given.

No MeSH data available.


Related in: MedlinePlus

Administrative districts of Nepal, showing the extent of the mapping exercise. Districts found positive are coloured in red, districts found negative in grey.
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Figure 1: Administrative districts of Nepal, showing the extent of the mapping exercise. Districts found positive are coloured in red, districts found negative in grey.

Mentions: The overall prevalence of lymphatic filariasis from a 4,488-sample population studied from 37 districts was 582 (13%); 33/37 districts were considered endemic on the basis of this preliminary study. A distribution of antigenemia above 20% was found in 11 districts with the highest rate of 40%, 6 to 19% were found in 15 districts, 0.1 to 5% were in 7 districts. Current categorization of endemicity level is shown in Figure 1, showing confirmed filaria-endemic districts in RED and districts contiguous to endemic districts but where endemicity was not confirmed in GREY; no study has yet been performed in the districts in WHITE. Detailed ICT results district-by-district are given on Table 1.


Mapping of lymphatic filariasis in Nepal.

Sherchand JB, Obsomer V, Thakur GD, Hommel M - Filaria J (2003)

Administrative districts of Nepal, showing the extent of the mapping exercise. Districts found positive are coloured in red, districts found negative in grey.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC153485&req=5

Figure 1: Administrative districts of Nepal, showing the extent of the mapping exercise. Districts found positive are coloured in red, districts found negative in grey.
Mentions: The overall prevalence of lymphatic filariasis from a 4,488-sample population studied from 37 districts was 582 (13%); 33/37 districts were considered endemic on the basis of this preliminary study. A distribution of antigenemia above 20% was found in 11 districts with the highest rate of 40%, 6 to 19% were found in 15 districts, 0.1 to 5% were in 7 districts. Current categorization of endemicity level is shown in Figure 1, showing confirmed filaria-endemic districts in RED and districts contiguous to endemic districts but where endemicity was not confirmed in GREY; no study has yet been performed in the districts in WHITE. Detailed ICT results district-by-district are given on Table 1.

Bottom Line: RESULTS: The overall prevalence of lymphatic filariasis from a 4,488-sample population was 13% and 33/37 districts were found to be endemic.On the basis of geographical data, the highest number of cases was found at altitudes between 500-700 m; however, a substantial number of infected individuals were found in the highly populated Kathmandu valley, at altitudes between 900-1,500 metres where transmission appears to take place.The study indicates that the prevalence of infection is far greater that was previously reported and that lymphatic filariasis should be a much higher health priority than currently given.

View Article: PubMed Central - HTML - PubMed

Affiliation: Liverpool School of Tropical Medicine, Disease Control Strategy Group, Pembroke Place L3 5QA, Liverpool, United Kingdom. mhommel@liv.ac.uk

ABSTRACT
BACKGROUND: Human infection with Wuchereria bancrofti causes a disabling parasitic disease known as lymphatic filariasis, which is a major public health and socio-economic problem in many parts of the world. At the onset of the study, little was known of the distribution of filariasis and its current importance as a public health problem in Nepal. METHODS: Epidemiological mapping was undertaken to determine the prevalence of infection by Wuchereria bancrofti in 37 districts of Nepal between July to December 2001. The study population above 15 years of age was selected, and the immunochromatographic test (ICT Filariasis) was used to screen for circulating filarial antigen (CFA). RESULTS: The overall prevalence of lymphatic filariasis from a 4,488-sample population was 13% and 33/37 districts were found to be endemic. On the basis of geographical data, the highest number of cases was found at altitudes between 500-700 m; however, a substantial number of infected individuals were found in the highly populated Kathmandu valley, at altitudes between 900-1,500 metres where transmission appears to take place. Prevalence rates above 20% were found in 11 districts (with the highest rate of 40%), 6-19% were found in 15 districts, and 0.1-5% were in 7 districts.Information on people's knowledge, attitudes and behaviour towards filariasis was also collected by means of a structured questionnaire, which is presented and discussed in the study. CONCLUSIONS: This is the most extensive study of lymphatic filariasis undertaken to date in Nepal. The study indicates that the prevalence of infection is far greater that was previously reported and that lymphatic filariasis should be a much higher health priority than currently given.

No MeSH data available.


Related in: MedlinePlus