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Some observations on the effect of Daflon (micronized purified flavonoid fraction of Rutaceae aurantiae) in bancroftian filarial lymphoedema.

Das L, Subramanyam Reddy G, Pani S - Filaria J (2003)

Bottom Line: The group receiving Daflon showed significant reduction in oedema volume from day 90 (140.6 PlusMinus; 18.8 ml) to day 360 (71.8 PlusMinus; 20.7 ml) compared to the pre-treatment (day 0, 198.4 PlusMinus; 16.5 ml) value.In the DEC group, the changes in oedema volume (between day 1 and day 360) were not significant when compared to the pre-treatment (day 0) value.The percentage reduction at day 360 was only 9%, which was not significant (P > 0.05).

View Article: PubMed Central - HTML - PubMed

Affiliation: Vector Control Research Centre, (Indian Council of Medical Research), Pondicherry-605006, India. sp_pani@vsnl.com

ABSTRACT
BACKGROUND: Morbidity management is a core component of the global programme for the elimination of lymphatic filariasis. In a double-blind clinical trial, the tolerability and efficacy of Daflon (500 mg) + DEC (25 mg) or DEC (25 mg) alone, twice daily for 90 days, was studied in 26 patients with bancroftian filarial lymphoedema. RESULTS: None of the patients in either drug group reported any adverse reaction throughout the treatment period (90 days). Haematological and biochemical parameters were within normal limits and there was no significant difference between the pre-treatment (day 0) and post-treatment (day 90) values. The group receiving Daflon showed significant reduction in oedema volume from day 90 (140.6 PlusMinus; 18.8 ml) to day 360 (71.8 PlusMinus; 20.7 ml) compared to the pre-treatment (day 0, 198.4 PlusMinus; 16.5 ml) value. This accounted for a 63.8% reduction in oedema volume by day 360 (considering the pre-treatment (day 0) as 100%). In the DEC group, the changes in oedema volume (between day 1 and day 360) were not significant when compared to the pre-treatment (day 0) value. The percentage reduction at day 360 was only 9%, which was not significant (P > 0.05). CONCLUSION: This study has shown that Daflon (500 mg, twice a day for 90 days) is both safe and efficacious in reducing oedema volume in bancroftian filarial lymphoedema. Further clinical trials are essential for strengthening the evidence base on the role of this drug in the morbidity management of lymphatic filariasis.

No MeSH data available.


Related in: MedlinePlus

Comparison of changes in mean (± SEM) oedema volume (in ml) over 360 days between patients treated with Daflon (500 mg) + DEC (25 mg), and patients treated with DEC (25 mg), twice daily for 90 days. Day 0: pre-treatment Day 1 – day 90 period of treatment Day 91 – day 360 period of follow-up *P = < 0.05 vs. day 0 **P = < 0.005 vs. day 0 ***P = < 0.001 vs. day 0
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Figure 1: Comparison of changes in mean (± SEM) oedema volume (in ml) over 360 days between patients treated with Daflon (500 mg) + DEC (25 mg), and patients treated with DEC (25 mg), twice daily for 90 days. Day 0: pre-treatment Day 1 – day 90 period of treatment Day 91 – day 360 period of follow-up *P = < 0.05 vs. day 0 **P = < 0.005 vs. day 0 ***P = < 0.001 vs. day 0

Mentions: The mean oedema volume (± SEM) in the Daflon + DEC group was 140.6 (± 18.8) ml at the end of treatment period (day 90) and it was 71.8 (± 20.7) ml at the end of the follow-up period (day 360) (Figure 1). There was a significant difference in the mean oedema volume on day 90 and on day 360 in comparison to the pre-treatment value (198.4 ± 16.5 ml on day 0, P < 0.05) (Table 2). The mean oedema (± SEM) volume in the DEC group was 272.9 ± 48.0 ml the end of the follow-up period (day 360) (Figure 1). There was no significant difference in the mean oedema volumes on day 90 and on day 360 in comparison to the pre-treatment value (272.9 ± 48.0 ml on day 0, P > 0.05).


Some observations on the effect of Daflon (micronized purified flavonoid fraction of Rutaceae aurantiae) in bancroftian filarial lymphoedema.

Das L, Subramanyam Reddy G, Pani S - Filaria J (2003)

Comparison of changes in mean (± SEM) oedema volume (in ml) over 360 days between patients treated with Daflon (500 mg) + DEC (25 mg), and patients treated with DEC (25 mg), twice daily for 90 days. Day 0: pre-treatment Day 1 – day 90 period of treatment Day 91 – day 360 period of follow-up *P = < 0.05 vs. day 0 **P = < 0.005 vs. day 0 ***P = < 0.001 vs. day 0
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC153483&req=5

Figure 1: Comparison of changes in mean (± SEM) oedema volume (in ml) over 360 days between patients treated with Daflon (500 mg) + DEC (25 mg), and patients treated with DEC (25 mg), twice daily for 90 days. Day 0: pre-treatment Day 1 – day 90 period of treatment Day 91 – day 360 period of follow-up *P = < 0.05 vs. day 0 **P = < 0.005 vs. day 0 ***P = < 0.001 vs. day 0
Mentions: The mean oedema volume (± SEM) in the Daflon + DEC group was 140.6 (± 18.8) ml at the end of treatment period (day 90) and it was 71.8 (± 20.7) ml at the end of the follow-up period (day 360) (Figure 1). There was a significant difference in the mean oedema volume on day 90 and on day 360 in comparison to the pre-treatment value (198.4 ± 16.5 ml on day 0, P < 0.05) (Table 2). The mean oedema (± SEM) volume in the DEC group was 272.9 ± 48.0 ml the end of the follow-up period (day 360) (Figure 1). There was no significant difference in the mean oedema volumes on day 90 and on day 360 in comparison to the pre-treatment value (272.9 ± 48.0 ml on day 0, P > 0.05).

Bottom Line: The group receiving Daflon showed significant reduction in oedema volume from day 90 (140.6 PlusMinus; 18.8 ml) to day 360 (71.8 PlusMinus; 20.7 ml) compared to the pre-treatment (day 0, 198.4 PlusMinus; 16.5 ml) value.In the DEC group, the changes in oedema volume (between day 1 and day 360) were not significant when compared to the pre-treatment (day 0) value.The percentage reduction at day 360 was only 9%, which was not significant (P > 0.05).

View Article: PubMed Central - HTML - PubMed

Affiliation: Vector Control Research Centre, (Indian Council of Medical Research), Pondicherry-605006, India. sp_pani@vsnl.com

ABSTRACT
BACKGROUND: Morbidity management is a core component of the global programme for the elimination of lymphatic filariasis. In a double-blind clinical trial, the tolerability and efficacy of Daflon (500 mg) + DEC (25 mg) or DEC (25 mg) alone, twice daily for 90 days, was studied in 26 patients with bancroftian filarial lymphoedema. RESULTS: None of the patients in either drug group reported any adverse reaction throughout the treatment period (90 days). Haematological and biochemical parameters were within normal limits and there was no significant difference between the pre-treatment (day 0) and post-treatment (day 90) values. The group receiving Daflon showed significant reduction in oedema volume from day 90 (140.6 PlusMinus; 18.8 ml) to day 360 (71.8 PlusMinus; 20.7 ml) compared to the pre-treatment (day 0, 198.4 PlusMinus; 16.5 ml) value. This accounted for a 63.8% reduction in oedema volume by day 360 (considering the pre-treatment (day 0) as 100%). In the DEC group, the changes in oedema volume (between day 1 and day 360) were not significant when compared to the pre-treatment (day 0) value. The percentage reduction at day 360 was only 9%, which was not significant (P > 0.05). CONCLUSION: This study has shown that Daflon (500 mg, twice a day for 90 days) is both safe and efficacious in reducing oedema volume in bancroftian filarial lymphoedema. Further clinical trials are essential for strengthening the evidence base on the role of this drug in the morbidity management of lymphatic filariasis.

No MeSH data available.


Related in: MedlinePlus