Limits...
Leishmania species and zymodemes isolated from endemic areas of cutaneous leishmaniasis in Jordan.

Nimri L, Soubani R, Gramiccia M - Kinetoplastid Biol Dis (2002)

Bottom Line: Four Leishmania major zymodemes were found, one of which was a new zymodeme (ZMON-103 variant in GLUD220); L. major ZMON-103 was the most common zymodeme.CONCLUSION: The findings of this study indicate the emergence of the CL disease in new areas.New foci are reported, where the sporadic nature of the cases indicates recent spread of the disease to these areas and the urge for the implementation of control measures.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Applied Biology, Jordan University of Science and Technology, P, O, Box 3030, Irbid 22110, Jordan. nimri@just.edu.jo

ABSTRACT
BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in the Middle Eastern countries. New cases are emerging in areas previously free of the disease. In Jordan, the diagnosis of cases during the 1960s and 1970s was mainly reported in military hospitals in Amman. Endemicity of the disease was ascertained after reporting a total of 524 cases during 1973-1978. RESULTS: Leishmania major and Leishmania tropica were isolated from seventy-six autochthonous and imported cases of CL, during eight-year period. The highest infection rates recorded were in the central part of Jordan (60.5%), in males (72.4%) and in the age group 21-30 years (30.5%). Lesions were on the exposed sites of the body, mainly on the face (40%). Both Leishmania spp. were isolated from all parts of the country, although L. major was the predominant species (75% of cases) in all areas except in the north part of Jordan. Isoenzyme characterization of the isolates identified four previously undescribed zymodemes (Z). Four Leishmania major zymodemes were found, one of which was a new zymodeme (ZMON-103 variant in GLUD220); L. major ZMON-103 was the most common zymodeme. Four Leishmania tropica zymodemes were identified, of which three were previously unreported. Of these, ZMON-54 var PGD96-97 was isolated from autochthonous cases, whereas ZMON-59 var MDH100 and ZMON-75 var FH110 were obtained from both autochthonous and imported cases, or from an imported CL case, respectively. CONCLUSION: The findings of this study indicate the emergence of the CL disease in new areas. New foci are reported, where the sporadic nature of the cases indicates recent spread of the disease to these areas and the urge for the implementation of control measures.

No MeSH data available.


Related in: MedlinePlus

Distribution of cutaneous leishmaniasis cases in Jordan during 1992–2000.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC149425&req=5

Figure 1: Distribution of cutaneous leishmaniasis cases in Jordan during 1992–2000.

Mentions: Patient's residence, working place, travel history and the time of appearance of the lesions were important data for determining the locations where the infections might have taken place. The numbers of positive cases in the north, central and south parts of Jordan are shown in Table 2. The highest infection rate (60.5%) was recorded in patients who are living or contracted the disease in the central part of Jordan (Figure 1) followed by the infection rate (14.5%) recorded for patients from the north. The lowest rate (13.2%) was recorded for patients living or contracted the disease in the south. The infection rate in patients who contracted the disease in the neighboring countries was 11.8 %. These patients worked and lived outside Jordan previous to the appearance of the lesions. The countries where they contacted the disease were Saudi Arabia (three in Taif and two in Riyadh), Iraq (two in Baghdad) and Syria (two in Aleppo); these countries are known to be endemic with CL.


Leishmania species and zymodemes isolated from endemic areas of cutaneous leishmaniasis in Jordan.

Nimri L, Soubani R, Gramiccia M - Kinetoplastid Biol Dis (2002)

Distribution of cutaneous leishmaniasis cases in Jordan during 1992–2000.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC149425&req=5

Figure 1: Distribution of cutaneous leishmaniasis cases in Jordan during 1992–2000.
Mentions: Patient's residence, working place, travel history and the time of appearance of the lesions were important data for determining the locations where the infections might have taken place. The numbers of positive cases in the north, central and south parts of Jordan are shown in Table 2. The highest infection rate (60.5%) was recorded in patients who are living or contracted the disease in the central part of Jordan (Figure 1) followed by the infection rate (14.5%) recorded for patients from the north. The lowest rate (13.2%) was recorded for patients living or contracted the disease in the south. The infection rate in patients who contracted the disease in the neighboring countries was 11.8 %. These patients worked and lived outside Jordan previous to the appearance of the lesions. The countries where they contacted the disease were Saudi Arabia (three in Taif and two in Riyadh), Iraq (two in Baghdad) and Syria (two in Aleppo); these countries are known to be endemic with CL.

Bottom Line: Four Leishmania major zymodemes were found, one of which was a new zymodeme (ZMON-103 variant in GLUD220); L. major ZMON-103 was the most common zymodeme.CONCLUSION: The findings of this study indicate the emergence of the CL disease in new areas.New foci are reported, where the sporadic nature of the cases indicates recent spread of the disease to these areas and the urge for the implementation of control measures.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Applied Biology, Jordan University of Science and Technology, P, O, Box 3030, Irbid 22110, Jordan. nimri@just.edu.jo

ABSTRACT
BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in the Middle Eastern countries. New cases are emerging in areas previously free of the disease. In Jordan, the diagnosis of cases during the 1960s and 1970s was mainly reported in military hospitals in Amman. Endemicity of the disease was ascertained after reporting a total of 524 cases during 1973-1978. RESULTS: Leishmania major and Leishmania tropica were isolated from seventy-six autochthonous and imported cases of CL, during eight-year period. The highest infection rates recorded were in the central part of Jordan (60.5%), in males (72.4%) and in the age group 21-30 years (30.5%). Lesions were on the exposed sites of the body, mainly on the face (40%). Both Leishmania spp. were isolated from all parts of the country, although L. major was the predominant species (75% of cases) in all areas except in the north part of Jordan. Isoenzyme characterization of the isolates identified four previously undescribed zymodemes (Z). Four Leishmania major zymodemes were found, one of which was a new zymodeme (ZMON-103 variant in GLUD220); L. major ZMON-103 was the most common zymodeme. Four Leishmania tropica zymodemes were identified, of which three were previously unreported. Of these, ZMON-54 var PGD96-97 was isolated from autochthonous cases, whereas ZMON-59 var MDH100 and ZMON-75 var FH110 were obtained from both autochthonous and imported cases, or from an imported CL case, respectively. CONCLUSION: The findings of this study indicate the emergence of the CL disease in new areas. New foci are reported, where the sporadic nature of the cases indicates recent spread of the disease to these areas and the urge for the implementation of control measures.

No MeSH data available.


Related in: MedlinePlus