Limits...
Mapping of neurokinin-like immunoreactivity in the human brainstem.

Coveñas R, Martin F, Belda M, Smith V, Salinas P, Rivada E, Diaz-Cabiale Z, Narvaez JA, Marcos P, Tramu G, Gonzalez-Baron S - BMC Neurosci (2003)

Bottom Line: Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata.In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Neurosciences of Castilla y León (INCYL), School of Medicine, Laboratory of Neuroanatomy of the Peptidergic Systems, Salamanca, Spain. covenas@gugu.usal.es

ABSTRACT

Background: Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.

Results: Clusters of immunoreactive cell bodies and high densities of neurokinin-immunoreactive fibers were located in the periaqueductal gray, the dorsal motor nucleus of the vagus and in the reticular formation of the medulla, pons and mesencephalon. Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata. In general, immunoreactive fibers containing neurokinin were observed throughout the whole brainstem. In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.

Conclusion: The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

Show MeSH

Related in: MedlinePlus

Distribution of NK-ir fibers and cell bodies in frontal planes of the human brainstem from the caudal (Fig. 1A) to the anterior (Fig. 3C) levels. Cell bodies containing neurokinin are represented by closed circles, whereas immunoreactive fibers are represented by dotted lines (single fibers or low density), continuous lines (moderate density) and crossed lines (high density). See list of abbreviations for nomenclature.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC149367&req=5

Figure 3: Distribution of NK-ir fibers and cell bodies in frontal planes of the human brainstem from the caudal (Fig. 1A) to the anterior (Fig. 3C) levels. Cell bodies containing neurokinin are represented by closed circles, whereas immunoreactive fibers are represented by dotted lines (single fibers or low density), continuous lines (moderate density) and crossed lines (high density). See list of abbreviations for nomenclature.

Mentions: As shown in Figures 1, 2, 3, neurokinin-like immunoreactive (NK-ir) structures are widely distributed throughout the human brainstem. In general, the distribution of the immunoreactive structures (fibers and cell bodies), as well as the density of such structures, were quite similar in the four brainstems studied. In the three brainstem regions (medulla oblongata, pons and mesencephalon), the highest density of immunoreactive structures was generally observed in their dorsal parts. In addition, the clusters of cell bodies containing NK were almost always observed in the dorsal part of the human brainstem. Finally, in general, the NK-ir cell bodies observed in the human brainstem were large (showing the longest diameter between 20–55 μm).


Mapping of neurokinin-like immunoreactivity in the human brainstem.

Coveñas R, Martin F, Belda M, Smith V, Salinas P, Rivada E, Diaz-Cabiale Z, Narvaez JA, Marcos P, Tramu G, Gonzalez-Baron S - BMC Neurosci (2003)

Distribution of NK-ir fibers and cell bodies in frontal planes of the human brainstem from the caudal (Fig. 1A) to the anterior (Fig. 3C) levels. Cell bodies containing neurokinin are represented by closed circles, whereas immunoreactive fibers are represented by dotted lines (single fibers or low density), continuous lines (moderate density) and crossed lines (high density). See list of abbreviations for nomenclature.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC149367&req=5

Figure 3: Distribution of NK-ir fibers and cell bodies in frontal planes of the human brainstem from the caudal (Fig. 1A) to the anterior (Fig. 3C) levels. Cell bodies containing neurokinin are represented by closed circles, whereas immunoreactive fibers are represented by dotted lines (single fibers or low density), continuous lines (moderate density) and crossed lines (high density). See list of abbreviations for nomenclature.
Mentions: As shown in Figures 1, 2, 3, neurokinin-like immunoreactive (NK-ir) structures are widely distributed throughout the human brainstem. In general, the distribution of the immunoreactive structures (fibers and cell bodies), as well as the density of such structures, were quite similar in the four brainstems studied. In the three brainstem regions (medulla oblongata, pons and mesencephalon), the highest density of immunoreactive structures was generally observed in their dorsal parts. In addition, the clusters of cell bodies containing NK were almost always observed in the dorsal part of the human brainstem. Finally, in general, the NK-ir cell bodies observed in the human brainstem were large (showing the longest diameter between 20–55 μm).

Bottom Line: Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata.In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Neurosciences of Castilla y León (INCYL), School of Medicine, Laboratory of Neuroanatomy of the Peptidergic Systems, Salamanca, Spain. covenas@gugu.usal.es

ABSTRACT

Background: Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.

Results: Clusters of immunoreactive cell bodies and high densities of neurokinin-immunoreactive fibers were located in the periaqueductal gray, the dorsal motor nucleus of the vagus and in the reticular formation of the medulla, pons and mesencephalon. Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata. In general, immunoreactive fibers containing neurokinin were observed throughout the whole brainstem. In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.

Conclusion: The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

Show MeSH
Related in: MedlinePlus