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Mapping of neurokinin-like immunoreactivity in the human brainstem.

Coveñas R, Martin F, Belda M, Smith V, Salinas P, Rivada E, Diaz-Cabiale Z, Narvaez JA, Marcos P, Tramu G, Gonzalez-Baron S - BMC Neurosci (2003)

Bottom Line: Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata.In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

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Affiliation: Institute of Neurosciences of Castilla y León (INCYL), School of Medicine, Laboratory of Neuroanatomy of the Peptidergic Systems, Salamanca, Spain. covenas@gugu.usal.es

ABSTRACT

Background: Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.

Results: Clusters of immunoreactive cell bodies and high densities of neurokinin-immunoreactive fibers were located in the periaqueductal gray, the dorsal motor nucleus of the vagus and in the reticular formation of the medulla, pons and mesencephalon. Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata. In general, immunoreactive fibers containing neurokinin were observed throughout the whole brainstem. In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.

Conclusion: The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

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A. NK-ir perikarya (arrows) and fibers (arrowheads) in the periaqueductal gray (PAG). D: dorsal; M: medial. Scale bar: 100 μm B. A low density of immunoreactive fibers is observed in layer 1 of the superior colliculus (SC), whereas a high density is located in layer 2. D: dorsal; M: medial. Scale bar: 100 μm
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Figure 10: A. NK-ir perikarya (arrows) and fibers (arrowheads) in the periaqueductal gray (PAG). D: dorsal; M: medial. Scale bar: 100 μm B. A low density of immunoreactive fibers is observed in layer 1 of the superior colliculus (SC), whereas a high density is located in layer 2. D: dorsal; M: medial. Scale bar: 100 μm

Mentions: In the mesencephalon two populations of cell bodies containing NK were observed. The first (high density) was located above the periaqueductal gray and the central nucleus of the inferior colliculus and extended into the latter nucleus (Figs. 3A; 8A,8B; 9A,9B). The second was observed in the periaqueductal gray (high density) (Figs. 3B; 10A) and in the reticular formation (low density) (Fig. 3B). In the caudal and rostral regions of the periaqueductal gray a low density of NK-ir perikarya was found in the ventromedial part of the nucleus (Fig. 3A,3C).


Mapping of neurokinin-like immunoreactivity in the human brainstem.

Coveñas R, Martin F, Belda M, Smith V, Salinas P, Rivada E, Diaz-Cabiale Z, Narvaez JA, Marcos P, Tramu G, Gonzalez-Baron S - BMC Neurosci (2003)

A. NK-ir perikarya (arrows) and fibers (arrowheads) in the periaqueductal gray (PAG). D: dorsal; M: medial. Scale bar: 100 μm B. A low density of immunoreactive fibers is observed in layer 1 of the superior colliculus (SC), whereas a high density is located in layer 2. D: dorsal; M: medial. Scale bar: 100 μm
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC149367&req=5

Figure 10: A. NK-ir perikarya (arrows) and fibers (arrowheads) in the periaqueductal gray (PAG). D: dorsal; M: medial. Scale bar: 100 μm B. A low density of immunoreactive fibers is observed in layer 1 of the superior colliculus (SC), whereas a high density is located in layer 2. D: dorsal; M: medial. Scale bar: 100 μm
Mentions: In the mesencephalon two populations of cell bodies containing NK were observed. The first (high density) was located above the periaqueductal gray and the central nucleus of the inferior colliculus and extended into the latter nucleus (Figs. 3A; 8A,8B; 9A,9B). The second was observed in the periaqueductal gray (high density) (Figs. 3B; 10A) and in the reticular formation (low density) (Fig. 3B). In the caudal and rostral regions of the periaqueductal gray a low density of NK-ir perikarya was found in the ventromedial part of the nucleus (Fig. 3A,3C).

Bottom Line: Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata.In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Neurosciences of Castilla y León (INCYL), School of Medicine, Laboratory of Neuroanatomy of the Peptidergic Systems, Salamanca, Spain. covenas@gugu.usal.es

ABSTRACT

Background: Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.

Results: Clusters of immunoreactive cell bodies and high densities of neurokinin-immunoreactive fibers were located in the periaqueductal gray, the dorsal motor nucleus of the vagus and in the reticular formation of the medulla, pons and mesencephalon. Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata. In general, immunoreactive fibers containing neurokinin were observed throughout the whole brainstem. In addition to the nuclei mentioned above, the highest densities of such immunoreactive fibers were located in the spinal trigeminal nucleus, the lateral reticular nucleus, the nucleus of the solitary tract, the superior colliculus, the substantia nigra, the nucleus ambiguus, the gracile nucleus, the cuneate nucleus, the motor hypoglossal nucleus, the medial and superior vestibular nuclei, the nucleus prepositus hypoglossi and the interpeduncular nucleus.

Conclusion: The widespread distribution of immunoreactive structures containing neurokinin in the human brainstem indicates that neurokinin might be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

Show MeSH
Related in: MedlinePlus