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Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000.

Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJ - BMC Cancer (2002)

Bottom Line: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death.Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast.There was a significant variations in the distribution of site-specific cancer mortality and incidence by region.

View Article: PubMed Central - HTML - PubMed

Affiliation: Global Program on Evidence for Health Policy, World Health Organization, Geneva, Switzerland. shibuyak@who.int

ABSTRACT

Background: Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of cancer burden for the Global Burden of Disease 2000 study.

Methods: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death. We estimated the site-specific cancer mortality distributions from vital records and cancer survival model. The regional cancer mortality by site is estimated by disaggregating the regional cancer mortality envelope based on the mortality distribution. Estimated incidence-to-mortality rate ratios were used to back calculate the final cancer incidence estimates by site.

Results: In 2000, cancer accounted for over 7 million deaths (13% of total mortality) and there were more than 10 million new cancer cases world wide in 2000. More than 60% of cancer deaths and approximately half of new cases occurred in developing regions. Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast. There was a significant variations in the distribution of site-specific cancer mortality and incidence by region.

Conclusions: Despite a regional variation, the most common cancers are potentially preventable. Cancer burden estimation by taking into account both mortality and morbidity is an essential step to set research priorities and policy formulation. Also it can used for setting priorities when combined with data on costs of interventions against cancers.

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Related in: MedlinePlus

Age-standardised mortality rate from all cancers by region, 2000
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Figure 3: Age-standardised mortality rate from all cancers by region, 2000

Mentions: Tables 2,3,4,5 show the regional estimates of total number of deaths and age-specific mortality rates of all cancers for the GBD 2000. More than 60% of cancer deaths occurred in developing regions, particularly in SearD (mainly India) and WprB1(mainly China) sub regions due to their large population size. On average global cancer mortality rates among males and females were 128.2 and 104.6 per 100,000, respectively. Not surprisingly crude mortality rates from all cancers vary significantly and are much higher in developed regions (AmrA, EurA, and WprA). However, since age-specific mortality rate is generally higher in developing regions, regional mortality rates, age-standardised to the world population, showed less variations compared to crude mortality rates and higher mortality rates were observed in regions such as AfrD, AfrE, AmrB, EurC, and WprB (Figure 3).


Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000.

Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJ - BMC Cancer (2002)

Age-standardised mortality rate from all cancers by region, 2000
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC149364&req=5

Figure 3: Age-standardised mortality rate from all cancers by region, 2000
Mentions: Tables 2,3,4,5 show the regional estimates of total number of deaths and age-specific mortality rates of all cancers for the GBD 2000. More than 60% of cancer deaths occurred in developing regions, particularly in SearD (mainly India) and WprB1(mainly China) sub regions due to their large population size. On average global cancer mortality rates among males and females were 128.2 and 104.6 per 100,000, respectively. Not surprisingly crude mortality rates from all cancers vary significantly and are much higher in developed regions (AmrA, EurA, and WprA). However, since age-specific mortality rate is generally higher in developing regions, regional mortality rates, age-standardised to the world population, showed less variations compared to crude mortality rates and higher mortality rates were observed in regions such as AfrD, AfrE, AmrB, EurC, and WprB (Figure 3).

Bottom Line: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death.Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast.There was a significant variations in the distribution of site-specific cancer mortality and incidence by region.

View Article: PubMed Central - HTML - PubMed

Affiliation: Global Program on Evidence for Health Policy, World Health Organization, Geneva, Switzerland. shibuyak@who.int

ABSTRACT

Background: Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of cancer burden for the Global Burden of Disease 2000 study.

Methods: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death. We estimated the site-specific cancer mortality distributions from vital records and cancer survival model. The regional cancer mortality by site is estimated by disaggregating the regional cancer mortality envelope based on the mortality distribution. Estimated incidence-to-mortality rate ratios were used to back calculate the final cancer incidence estimates by site.

Results: In 2000, cancer accounted for over 7 million deaths (13% of total mortality) and there were more than 10 million new cancer cases world wide in 2000. More than 60% of cancer deaths and approximately half of new cases occurred in developing regions. Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast. There was a significant variations in the distribution of site-specific cancer mortality and incidence by region.

Conclusions: Despite a regional variation, the most common cancers are potentially preventable. Cancer burden estimation by taking into account both mortality and morbidity is an essential step to set research priorities and policy formulation. Also it can used for setting priorities when combined with data on costs of interventions against cancers.

Show MeSH
Related in: MedlinePlus