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Understanding gastrointestinal perfusion in critical care: so near, and yet so far.

Ackland G, Grocott MP, Mythen MG - Crit Care (2000)

Bottom Line: Much of the data to support this idea comes from studies using gastric tonometry.Furthermore, current understanding of the physiology of gastrointestinal perfusion in health and disease is incomplete.This review considers critically the striking clinical data and basic physiological investigations that support a key role for gastrointestinal hypoperfusion in initiating and/or perpetuating critical disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Anaesthesia, University College London, London, UK.

ABSTRACT
An association between abnormal gastrointestinal perfusion and critical illness has been suggested for a number of years. Much of the data to support this idea comes from studies using gastric tonometry. Although an attractive technology, the interpretation of tonometry data is complex. Furthermore, current understanding of the physiology of gastrointestinal perfusion in health and disease is incomplete. This review considers critically the striking clinical data and basic physiological investigations that support a key role for gastrointestinal hypoperfusion in initiating and/or perpetuating critical disease.

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Related in: MedlinePlus

A dynamic balance between vasodilatation and vasoconstriction in the gastrointestinal blood supply exists during both health and disease.
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Figure 3: A dynamic balance between vasodilatation and vasoconstriction in the gastrointestinal blood supply exists during both health and disease.

Mentions: Under normal circumstances, in addition to the fundamental role of the splanchnic circulation in maintaining liver and gut perfusion to maintain mucosal integrity, the splanchnic bed also acts as a 'circulatory sink' [27]. The redistribution of blood flow that occurs during feeding and exercise are routine haemodynamic challenges for the splanchnic circulation. Exploration of how splanchnic perfusion copes at these extremes of normal homeostatic function illustrates the regulatory mechanisms at play (Fig. 3).


Understanding gastrointestinal perfusion in critical care: so near, and yet so far.

Ackland G, Grocott MP, Mythen MG - Crit Care (2000)

A dynamic balance between vasodilatation and vasoconstriction in the gastrointestinal blood supply exists during both health and disease.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC137256&req=5

Figure 3: A dynamic balance between vasodilatation and vasoconstriction in the gastrointestinal blood supply exists during both health and disease.
Mentions: Under normal circumstances, in addition to the fundamental role of the splanchnic circulation in maintaining liver and gut perfusion to maintain mucosal integrity, the splanchnic bed also acts as a 'circulatory sink' [27]. The redistribution of blood flow that occurs during feeding and exercise are routine haemodynamic challenges for the splanchnic circulation. Exploration of how splanchnic perfusion copes at these extremes of normal homeostatic function illustrates the regulatory mechanisms at play (Fig. 3).

Bottom Line: Much of the data to support this idea comes from studies using gastric tonometry.Furthermore, current understanding of the physiology of gastrointestinal perfusion in health and disease is incomplete.This review considers critically the striking clinical data and basic physiological investigations that support a key role for gastrointestinal hypoperfusion in initiating and/or perpetuating critical disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Anaesthesia, University College London, London, UK.

ABSTRACT
An association between abnormal gastrointestinal perfusion and critical illness has been suggested for a number of years. Much of the data to support this idea comes from studies using gastric tonometry. Although an attractive technology, the interpretation of tonometry data is complex. Furthermore, current understanding of the physiology of gastrointestinal perfusion in health and disease is incomplete. This review considers critically the striking clinical data and basic physiological investigations that support a key role for gastrointestinal hypoperfusion in initiating and/or perpetuating critical disease.

Show MeSH
Related in: MedlinePlus