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Modelling vaccination schedules for a cancer immunoprevention vaccine.

Motta S, Castiglione F, Lollini P, Pappalardo F - Immunome Res (2005)

Bottom Line: This model accurately reproduces in-vivo experiments results on HER-2/neu mice treated with the immuno-prevention cancer vaccine (Triplex) for mammary carcinoma.In vivo experiments have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma.We found that, applying the vaccination scheme used in in-vivo experiments, the number of vaccine injections can be reduced roughly by 30%.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Mathematics and Computer Science, University of Catania, Catania, Italy. motta@dmi.unict.it

ABSTRACT
We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs immune system competition activated by tumor vaccine. This model accurately reproduces in-vivo experiments results on HER-2/neu mice treated with the immuno-prevention cancer vaccine (Triplex) for mammary carcinoma. In vivo experiments have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma. The full protection was conferred using chronic (prophylactic) vaccination protocol while therapeutic vaccination was less efficient. In the present paper we use the computer simulations to systematically search for a vaccination schedule which prevents solid tumor formation. The strategy we used for defining a successful vaccination schedule is to control the number of cancer cells with vaccination cycles. We found that, applying the vaccination scheme used in in-vivo experiments, the number of vaccine injections can be reduced roughly by 30%.

No MeSH data available.


Related in: MedlinePlus

Immune response. The immune response activation due to the vaccine effect is shown for a possible vaccination schedules, versus time in days. Red ticks above x axis represent the timing of vaccine administration.
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Related In: Results  -  Collection

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Figure 11: Immune response. The immune response activation due to the vaccine effect is shown for a possible vaccination schedules, versus time in days. Red ticks above x axis represent the timing of vaccine administration.

Mentions: We get the tumor control for 85% of mice of the sample with the schedule shown in Figure 11, which shows the mean values for all mice of sample S1 in order to compare with previous figures.


Modelling vaccination schedules for a cancer immunoprevention vaccine.

Motta S, Castiglione F, Lollini P, Pappalardo F - Immunome Res (2005)

Immune response. The immune response activation due to the vaccine effect is shown for a possible vaccination schedules, versus time in days. Red ticks above x axis represent the timing of vaccine administration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1287065&req=5

Figure 11: Immune response. The immune response activation due to the vaccine effect is shown for a possible vaccination schedules, versus time in days. Red ticks above x axis represent the timing of vaccine administration.
Mentions: We get the tumor control for 85% of mice of the sample with the schedule shown in Figure 11, which shows the mean values for all mice of sample S1 in order to compare with previous figures.

Bottom Line: This model accurately reproduces in-vivo experiments results on HER-2/neu mice treated with the immuno-prevention cancer vaccine (Triplex) for mammary carcinoma.In vivo experiments have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma.We found that, applying the vaccination scheme used in in-vivo experiments, the number of vaccine injections can be reduced roughly by 30%.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Mathematics and Computer Science, University of Catania, Catania, Italy. motta@dmi.unict.it

ABSTRACT
We present a systematic approach to search for an effective vaccination schedule using mathematical computerized models. Our study is based on our previous model that simulates the cancer vs immune system competition activated by tumor vaccine. This model accurately reproduces in-vivo experiments results on HER-2/neu mice treated with the immuno-prevention cancer vaccine (Triplex) for mammary carcinoma. In vivo experiments have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma. The full protection was conferred using chronic (prophylactic) vaccination protocol while therapeutic vaccination was less efficient. In the present paper we use the computer simulations to systematically search for a vaccination schedule which prevents solid tumor formation. The strategy we used for defining a successful vaccination schedule is to control the number of cancer cells with vaccination cycles. We found that, applying the vaccination scheme used in in-vivo experiments, the number of vaccine injections can be reduced roughly by 30%.

No MeSH data available.


Related in: MedlinePlus