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From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality.

De Souza W - Kinetoplastid Biol Dis (2002)

Bottom Line: These organisms are also of biological interest since they are able to change the morphology according to the environment where they live, through a process of reversible cell transformation, and possess structures and organelles that are not found in mammalian cells.In addition, the present knowledge of structures and organelles such as the nucleus, the plasma membrane, the sub-pellicular microtubules, the flagellum, the kinetoplast-mitochondrion complex, the peroxisome (glycosome), the acidocalcisome and the structures and organelles involved in the endocytic pathway, is reviewed from a cell biology perspective.The possible use of available data for the development of new anti parasite drugs is also discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCSBloco G, 21941900, Rio de JaneiroRJ, Brasil. wsouza@biof.ufrj.br

ABSTRACT
Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These organisms are also of biological interest since they are able to change the morphology according to the environment where they live, through a process of reversible cell transformation, and possess structures and organelles that are not found in mammalian cells. This review analyses the process of transformation, which takes place during the life cycle of Trypanosoma cruzi in the vertebrate and invertebrate hosts. Special attention is given to the interaction of the parasite with vertebrate cells. In addition, the present knowledge of structures and organelles such as the nucleus, the plasma membrane, the sub-pellicular microtubules, the flagellum, the kinetoplast-mitochondrion complex, the peroxisome (glycosome), the acidocalcisome and the structures and organelles involved in the endocytic pathway, is reviewed from a cell biology perspective. The possible use of available data for the development of new anti parasite drugs is also discussed.

No MeSH data available.


Related in: MedlinePlus

Schematic view of the various phases of the interaction of T. cruzi with vertebrate cells.
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Figure 4: Schematic view of the various phases of the interaction of T. cruzi with vertebrate cells.

Mentions: The trypomastigote forms eliminated in the feces and urine of the invertebrate host are able to penetrate into vertebrate cells where they transform into spheromastigotes (Fig. 4). These divide repeatedly by binary fission and give rise to trypomastigotes that are liberated into the intercellular space, may reach the bloodstream, and can penetrate into other cells initiating a new cycle. Contrary to what is known for the African trypanosomes, the trypomastigote form of T cruzi does not divide in the bloodstream. Two morphological types of bloodstream trypomastigotes have been observed: one is slender, with an elongated nucleus, a subterminal kinetoplast, and a short free flagellum; the other is broad, with an oval nucleus, an almost terminal kinetoplast, and a long free flagellum. The predominance of one form over the other is dependent on the strain of T. cruzi and the time of infection. It has been suggested that the slender forms are mainly responsible for the infection of the vertebrate cells while the broad forms are more able to infect the invertebrate host [Review in [10]].


From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality.

De Souza W - Kinetoplastid Biol Dis (2002)

Schematic view of the various phases of the interaction of T. cruzi with vertebrate cells.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC119324&req=5

Figure 4: Schematic view of the various phases of the interaction of T. cruzi with vertebrate cells.
Mentions: The trypomastigote forms eliminated in the feces and urine of the invertebrate host are able to penetrate into vertebrate cells where they transform into spheromastigotes (Fig. 4). These divide repeatedly by binary fission and give rise to trypomastigotes that are liberated into the intercellular space, may reach the bloodstream, and can penetrate into other cells initiating a new cycle. Contrary to what is known for the African trypanosomes, the trypomastigote form of T cruzi does not divide in the bloodstream. Two morphological types of bloodstream trypomastigotes have been observed: one is slender, with an elongated nucleus, a subterminal kinetoplast, and a short free flagellum; the other is broad, with an oval nucleus, an almost terminal kinetoplast, and a long free flagellum. The predominance of one form over the other is dependent on the strain of T. cruzi and the time of infection. It has been suggested that the slender forms are mainly responsible for the infection of the vertebrate cells while the broad forms are more able to infect the invertebrate host [Review in [10]].

Bottom Line: These organisms are also of biological interest since they are able to change the morphology according to the environment where they live, through a process of reversible cell transformation, and possess structures and organelles that are not found in mammalian cells.In addition, the present knowledge of structures and organelles such as the nucleus, the plasma membrane, the sub-pellicular microtubules, the flagellum, the kinetoplast-mitochondrion complex, the peroxisome (glycosome), the acidocalcisome and the structures and organelles involved in the endocytic pathway, is reviewed from a cell biology perspective.The possible use of available data for the development of new anti parasite drugs is also discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCSBloco G, 21941900, Rio de JaneiroRJ, Brasil. wsouza@biof.ufrj.br

ABSTRACT
Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These organisms are also of biological interest since they are able to change the morphology according to the environment where they live, through a process of reversible cell transformation, and possess structures and organelles that are not found in mammalian cells. This review analyses the process of transformation, which takes place during the life cycle of Trypanosoma cruzi in the vertebrate and invertebrate hosts. Special attention is given to the interaction of the parasite with vertebrate cells. In addition, the present knowledge of structures and organelles such as the nucleus, the plasma membrane, the sub-pellicular microtubules, the flagellum, the kinetoplast-mitochondrion complex, the peroxisome (glycosome), the acidocalcisome and the structures and organelles involved in the endocytic pathway, is reviewed from a cell biology perspective. The possible use of available data for the development of new anti parasite drugs is also discussed.

No MeSH data available.


Related in: MedlinePlus