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Bcipep: a database of B-cell epitopes.

Saha S, Bhasin M, Raghava GP - BMC Genomics (2005)

Bottom Line: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens.The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy.It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Microbial Technology Chandigarh, India. saha@imtech.res.in <saha@imtech.res.in>

ABSTRACT

Background: Bcipep is a database of experimentally determined linear B-cell epitopes of varying immunogenicity collected from literature and other publicly available databases.

Results: The current version of Bcipep database contains 3031 entries that include 763 immunodominant, 1797 immunogenic and 471 -immunogenic epitopes. It covers a wide range of pathogenic organisms like viruses, bacteria, protozoa, and fungi. The database provides a set of tools for the analysis and extraction of data that includes keyword search, peptide mapping and BLAST search. It also provides hyperlinks to various databases such as GenBank, PDB, SWISS-PROT and MHCBN.

Conclusion: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens. The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy. It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes. The database is available at http://www.imtech.res.in/raghava/bcipep.

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Related in: MedlinePlus

This example illustrate peptide search on Bcipep; a) Peptide search page; and b) result of peptide search.
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Figure 3: This example illustrate peptide search on Bcipep; a) Peptide search page; and b) result of peptide search.

Mentions: The database provides option to search a peptide in Bcipep. The tool will display full information about the peptides included in Bcipep. The server also permits users to search their query sequence in any pathogen group. Search can be restricted on the basis of immunogencity that is immunodominant, immunogenic or -immunogenic. An example of input and output of peptide search is shown in Figures 3a and 3b respectively.


Bcipep: a database of B-cell epitopes.

Saha S, Bhasin M, Raghava GP - BMC Genomics (2005)

This example illustrate peptide search on Bcipep; a) Peptide search page; and b) result of peptide search.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1173103&req=5

Figure 3: This example illustrate peptide search on Bcipep; a) Peptide search page; and b) result of peptide search.
Mentions: The database provides option to search a peptide in Bcipep. The tool will display full information about the peptides included in Bcipep. The server also permits users to search their query sequence in any pathogen group. Search can be restricted on the basis of immunogencity that is immunodominant, immunogenic or -immunogenic. An example of input and output of peptide search is shown in Figures 3a and 3b respectively.

Bottom Line: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens.The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy.It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Microbial Technology Chandigarh, India. saha@imtech.res.in <saha@imtech.res.in>

ABSTRACT

Background: Bcipep is a database of experimentally determined linear B-cell epitopes of varying immunogenicity collected from literature and other publicly available databases.

Results: The current version of Bcipep database contains 3031 entries that include 763 immunodominant, 1797 immunogenic and 471 -immunogenic epitopes. It covers a wide range of pathogenic organisms like viruses, bacteria, protozoa, and fungi. The database provides a set of tools for the analysis and extraction of data that includes keyword search, peptide mapping and BLAST search. It also provides hyperlinks to various databases such as GenBank, PDB, SWISS-PROT and MHCBN.

Conclusion: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens. The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy. It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes. The database is available at http://www.imtech.res.in/raghava/bcipep.

Show MeSH
Related in: MedlinePlus