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Bcipep: a database of B-cell epitopes.

Saha S, Bhasin M, Raghava GP - BMC Genomics (2005)

Bottom Line: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens.The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy.It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Microbial Technology Chandigarh, India. saha@imtech.res.in <saha@imtech.res.in>

ABSTRACT

Background: Bcipep is a database of experimentally determined linear B-cell epitopes of varying immunogenicity collected from literature and other publicly available databases.

Results: The current version of Bcipep database contains 3031 entries that include 763 immunodominant, 1797 immunogenic and 471 -immunogenic epitopes. It covers a wide range of pathogenic organisms like viruses, bacteria, protozoa, and fungi. The database provides a set of tools for the analysis and extraction of data that includes keyword search, peptide mapping and BLAST search. It also provides hyperlinks to various databases such as GenBank, PDB, SWISS-PROT and MHCBN.

Conclusion: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens. The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy. It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes. The database is available at http://www.imtech.res.in/raghava/bcipep.

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The typical display of Bcipep database for keyword search; a) input page of keyword search; and b) output of keyword search.
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Figure 2: The typical display of Bcipep database for keyword search; a) input page of keyword search; and b) output of keyword search.

Mentions: This option allows users to perform search on all fields of the database ('Peptide Sequence', 'Source Protein', 'Publication Reference', 'Database Reference'). One can restrict the keyword search on any specific field. It also allows users to select the fields to be displayed. An example of keyword search is shown in Figure 2a, where key word 'P26694' is searched in any filed of database. The output/result of this keyword search is shown in Figure 2b.


Bcipep: a database of B-cell epitopes.

Saha S, Bhasin M, Raghava GP - BMC Genomics (2005)

The typical display of Bcipep database for keyword search; a) input page of keyword search; and b) output of keyword search.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1173103&req=5

Figure 2: The typical display of Bcipep database for keyword search; a) input page of keyword search; and b) output of keyword search.
Mentions: This option allows users to perform search on all fields of the database ('Peptide Sequence', 'Source Protein', 'Publication Reference', 'Database Reference'). One can restrict the keyword search on any specific field. It also allows users to select the fields to be displayed. An example of keyword search is shown in Figure 2a, where key word 'P26694' is searched in any filed of database. The output/result of this keyword search is shown in Figure 2b.

Bottom Line: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens.The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy.It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Microbial Technology Chandigarh, India. saha@imtech.res.in <saha@imtech.res.in>

ABSTRACT

Background: Bcipep is a database of experimentally determined linear B-cell epitopes of varying immunogenicity collected from literature and other publicly available databases.

Results: The current version of Bcipep database contains 3031 entries that include 763 immunodominant, 1797 immunogenic and 471 -immunogenic epitopes. It covers a wide range of pathogenic organisms like viruses, bacteria, protozoa, and fungi. The database provides a set of tools for the analysis and extraction of data that includes keyword search, peptide mapping and BLAST search. It also provides hyperlinks to various databases such as GenBank, PDB, SWISS-PROT and MHCBN.

Conclusion: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens. The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy. It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes. The database is available at http://www.imtech.res.in/raghava/bcipep.

Show MeSH
Related in: MedlinePlus