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Female breast cancer incidence and survival in Utah according to religious preference, 1985-1999.

Merrill RM, Folsom JA - BMC Cancer (2005)

Bottom Line: Rates were lower among LDS compared with non-LDS across the age span.In 1995-99, the age-adjusted incidence rates were 107.6 (95% CI: 103.9 - 111.3) for LDS women and 130.5 (123.2 - 137.9) for non-LDS women.With religiously active LDS serving as the reference group, the adjusted death hazard ratio for religiously less active LDS was 1.09 (0.94 - 1.27) and for non-LDS was 0.86 (0.75 - 0.98).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Science, College of Health and Human Performance, Brigham Young University, Provo, Utah, USA. Ray_Merrill@byu.edu

ABSTRACT

Background: Female breast cancer incidence rates in Utah are among the lowest in the U.S. The influence of the Church of Jesus Christ of Latter-day Saint (LDS or Mormon) religion on these rates, as well as on disease-specific survival, will be explored for individuals diagnosed with breast cancer in Utah from 1985 through 1999.

Methods: Population-based records for incident female breast cancer patients were linked with membership records from the LDS Church to determine religious affiliation and, for LDS Church members, level of religiosity. Incidence rates were age-adjusted to the 2000 U.S. standard population using the direct method. Cox proportional hazards model was used to compare survival among religiously active LDS, less religiously active LDS, and non-LDS with simultaneous adjustment for prognostic factors.

Results: Age-adjusted breast cancer incidence rates were consistently lower for LDS than non-LDS in Utah from 1985 through 1999. Rates were lower among LDS compared with non-LDS across the age span. In 1995-99, the age-adjusted incidence rates were 107.6 (95% CI: 103.9 - 111.3) for LDS women and 130.5 (123.2 - 137.9) for non-LDS women. If non-LDS women in Utah had the same breast cancer risk profile as LDS women, an estimated 214 (4.8%) fewer malignant breast cancer cases would have occurred during 1995-99. With religiously active LDS serving as the reference group, the adjusted death hazard ratio for religiously less active LDS was 1.09 (0.94 - 1.27) and for non-LDS was 0.86 (0.75 - 0.98).

Conclusion: In Utah, LDS lifestyle is associated with lower incidence rates of female breast cancer. However, LDS experience poorer survivability from breast cancer than their non-LDS counterparts. Parity and breastfeeding, while protective factors against breast cancer, may contribute to poorer prognosis of female breast cancer in LDS women.

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Age-specific malignant breast cancer incidence among white women in Utah according to LDS status, 1995–99
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Figure 2: Age-specific malignant breast cancer incidence among white women in Utah according to LDS status, 1995–99

Mentions: For the combined years 1995 through 1999, lower female malignant breast cancer incidence rates among LDS compared with non-LDS women in Utah were observed across the age span (Figure 2). Age-adjusted breast cancer incidence rates were 107.6 (95% CI: 103.9 – 111.3) for LDS women and 130.5 (123.2 – 137.9) for non-LDS women. In SEER (without Utah) the age-adjusted breast cancer incidence rate was 141.9 (140.9 – 142.9). Hypothetically speaking, if non-LDS women in Utah had the same breast cancer risk profile as LDS women, 214 (4.8%) fewer malignant breast cancer cases would have occurred during 1995–99. If the 9 SEER regions had the same breast cancer risk profile as women in Utah, 12,261 (16.2%) fewer malignant breast cancer cases would have occurred. If the 9 SEER regions had the same breast cancer risk profile as LDS women in Utah, 16,947 (22.4%) fewer malignant breast cancer cases would have occurred.


Female breast cancer incidence and survival in Utah according to religious preference, 1985-1999.

Merrill RM, Folsom JA - BMC Cancer (2005)

Age-specific malignant breast cancer incidence among white women in Utah according to LDS status, 1995–99
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1173093&req=5

Figure 2: Age-specific malignant breast cancer incidence among white women in Utah according to LDS status, 1995–99
Mentions: For the combined years 1995 through 1999, lower female malignant breast cancer incidence rates among LDS compared with non-LDS women in Utah were observed across the age span (Figure 2). Age-adjusted breast cancer incidence rates were 107.6 (95% CI: 103.9 – 111.3) for LDS women and 130.5 (123.2 – 137.9) for non-LDS women. In SEER (without Utah) the age-adjusted breast cancer incidence rate was 141.9 (140.9 – 142.9). Hypothetically speaking, if non-LDS women in Utah had the same breast cancer risk profile as LDS women, 214 (4.8%) fewer malignant breast cancer cases would have occurred during 1995–99. If the 9 SEER regions had the same breast cancer risk profile as women in Utah, 12,261 (16.2%) fewer malignant breast cancer cases would have occurred. If the 9 SEER regions had the same breast cancer risk profile as LDS women in Utah, 16,947 (22.4%) fewer malignant breast cancer cases would have occurred.

Bottom Line: Rates were lower among LDS compared with non-LDS across the age span.In 1995-99, the age-adjusted incidence rates were 107.6 (95% CI: 103.9 - 111.3) for LDS women and 130.5 (123.2 - 137.9) for non-LDS women.With religiously active LDS serving as the reference group, the adjusted death hazard ratio for religiously less active LDS was 1.09 (0.94 - 1.27) and for non-LDS was 0.86 (0.75 - 0.98).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Health Science, College of Health and Human Performance, Brigham Young University, Provo, Utah, USA. Ray_Merrill@byu.edu

ABSTRACT

Background: Female breast cancer incidence rates in Utah are among the lowest in the U.S. The influence of the Church of Jesus Christ of Latter-day Saint (LDS or Mormon) religion on these rates, as well as on disease-specific survival, will be explored for individuals diagnosed with breast cancer in Utah from 1985 through 1999.

Methods: Population-based records for incident female breast cancer patients were linked with membership records from the LDS Church to determine religious affiliation and, for LDS Church members, level of religiosity. Incidence rates were age-adjusted to the 2000 U.S. standard population using the direct method. Cox proportional hazards model was used to compare survival among religiously active LDS, less religiously active LDS, and non-LDS with simultaneous adjustment for prognostic factors.

Results: Age-adjusted breast cancer incidence rates were consistently lower for LDS than non-LDS in Utah from 1985 through 1999. Rates were lower among LDS compared with non-LDS across the age span. In 1995-99, the age-adjusted incidence rates were 107.6 (95% CI: 103.9 - 111.3) for LDS women and 130.5 (123.2 - 137.9) for non-LDS women. If non-LDS women in Utah had the same breast cancer risk profile as LDS women, an estimated 214 (4.8%) fewer malignant breast cancer cases would have occurred during 1995-99. With religiously active LDS serving as the reference group, the adjusted death hazard ratio for religiously less active LDS was 1.09 (0.94 - 1.27) and for non-LDS was 0.86 (0.75 - 0.98).

Conclusion: In Utah, LDS lifestyle is associated with lower incidence rates of female breast cancer. However, LDS experience poorer survivability from breast cancer than their non-LDS counterparts. Parity and breastfeeding, while protective factors against breast cancer, may contribute to poorer prognosis of female breast cancer in LDS women.

Show MeSH
Related in: MedlinePlus