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Transcriptional territories in the genome.

Weitzman JB - J. Biol. (2002)

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ABSTRACT

An analysis of numerous Drosophila microarray experiments reveals that the genome has many large groups of adjacent genes that are expressed similarly but are not functionally related.

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Mentions: "I was stunned when I saw the first results" recalls Spellman. "We really hadn't predicted this." (See the 'Behind the scenes' box for more of the background to the work.) The groups have an average size of 12-15 genes, with individual groups spanning up to 450 kilobases. Spellman carried out a series of rigorous checks to ensure that the results were real. The gene groups are not related to the banding patterns of Drosophila polytene chromosomes nor to known chromosomal structures such as scaffold-attachment sites. Computational analysis of the groups also demonstrated that they could not be explained by any detectable similarity between the genes within similarly expressed groups - not gene homology, gene ontology, or related function.


Transcriptional territories in the genome.

Weitzman JB - J. Biol. (2002)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC117245&req=5

Mentions: "I was stunned when I saw the first results" recalls Spellman. "We really hadn't predicted this." (See the 'Behind the scenes' box for more of the background to the work.) The groups have an average size of 12-15 genes, with individual groups spanning up to 450 kilobases. Spellman carried out a series of rigorous checks to ensure that the results were real. The gene groups are not related to the banding patterns of Drosophila polytene chromosomes nor to known chromosomal structures such as scaffold-attachment sites. Computational analysis of the groups also demonstrated that they could not be explained by any detectable similarity between the genes within similarly expressed groups - not gene homology, gene ontology, or related function.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

An analysis of numerous Drosophila microarray experiments reveals that the genome has many large groups of adjacent genes that are expressed similarly but are not functionally related.

Show MeSH