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Conducting systematic reviews of diagnostic studies: didactic guidelines.

Devillé WL, Buntinx F, Bouter LM, Montori VM, de Vet HC, van der Windt DA, Bezemer PD - BMC Med Res Methodol (2002)

Bottom Line: Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed information.Development of guidelines based on a systematic review of the evidence in reports of systematic searches of the literature for diagnostic research, of methodological criteria to evaluate diagnostic research, of methods for statistical pooling of data on diagnostic accuracy, and of methods for exploring heterogeneity.Examples are given using the results of two systematic reviews on the accuracy of the urine dipstick in the diagnosis of urinary tract infections, and on the accuracy of the straight-leg-raising test in the diagnosis of intervertebral disc hernia.

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Affiliation: Institute for Research in Extramural Medicine (EMGO Institute), VU University Medical Centre, Amsterdam, The Netherlands. w.deville@nivel.nl

ABSTRACT

Background: Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed information.

Methods: Development of guidelines based on a systematic review of the evidence in reports of systematic searches of the literature for diagnostic research, of methodological criteria to evaluate diagnostic research, of methods for statistical pooling of data on diagnostic accuracy, and of methods for exploring heterogeneity.

Results: Guidelines for conducting diagnostic systematic reviews are presented in a stepwise fashion and are followed by comments providing further information. Examples are given using the results of two systematic reviews on the accuracy of the urine dipstick in the diagnosis of urinary tract infections, and on the accuracy of the straight-leg-raising test in the diagnosis of intervertebral disc hernia.

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Related in: MedlinePlus

Sub-group analyses of the accuracy of the Lasègue's test for the diagnosis of disc hernia in low back pain. Odds ratios are pooled per sub-group.
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Figure 4: Sub-group analyses of the accuracy of the Lasègue's test for the diagnosis of disc hernia in low back pain. Odds ratios are pooled per sub-group.

Mentions: Example taken from the straight-leg-raising test review. In Figure 4 the DOR and confidence boundaries are plotted on the y-axis on a logarithmic scale. Relevant study characteristics (i.e., double-blind versus single-blind studies, studies with or without verification bias) are plotted on the x-axis.


Conducting systematic reviews of diagnostic studies: didactic guidelines.

Devillé WL, Buntinx F, Bouter LM, Montori VM, de Vet HC, van der Windt DA, Bezemer PD - BMC Med Res Methodol (2002)

Sub-group analyses of the accuracy of the Lasègue's test for the diagnosis of disc hernia in low back pain. Odds ratios are pooled per sub-group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC117243&req=5

Figure 4: Sub-group analyses of the accuracy of the Lasègue's test for the diagnosis of disc hernia in low back pain. Odds ratios are pooled per sub-group.
Mentions: Example taken from the straight-leg-raising test review. In Figure 4 the DOR and confidence boundaries are plotted on the y-axis on a logarithmic scale. Relevant study characteristics (i.e., double-blind versus single-blind studies, studies with or without verification bias) are plotted on the x-axis.

Bottom Line: Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed information.Development of guidelines based on a systematic review of the evidence in reports of systematic searches of the literature for diagnostic research, of methodological criteria to evaluate diagnostic research, of methods for statistical pooling of data on diagnostic accuracy, and of methods for exploring heterogeneity.Examples are given using the results of two systematic reviews on the accuracy of the urine dipstick in the diagnosis of urinary tract infections, and on the accuracy of the straight-leg-raising test in the diagnosis of intervertebral disc hernia.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Research in Extramural Medicine (EMGO Institute), VU University Medical Centre, Amsterdam, The Netherlands. w.deville@nivel.nl

ABSTRACT

Background: Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed information.

Methods: Development of guidelines based on a systematic review of the evidence in reports of systematic searches of the literature for diagnostic research, of methodological criteria to evaluate diagnostic research, of methods for statistical pooling of data on diagnostic accuracy, and of methods for exploring heterogeneity.

Results: Guidelines for conducting diagnostic systematic reviews are presented in a stepwise fashion and are followed by comments providing further information. Examples are given using the results of two systematic reviews on the accuracy of the urine dipstick in the diagnosis of urinary tract infections, and on the accuracy of the straight-leg-raising test in the diagnosis of intervertebral disc hernia.

Show MeSH
Related in: MedlinePlus