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Aged garlic extract therapy for sickle cell anemia patients.

Takasu J, Uykimpang R, Sunga M, Amagase H, Niihara Y - BMC Blood Disord (2002)

Bottom Line: With this disorder oxidative, phenomena play a significant role in its pathophysiology.In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03).CONCLUSIONS: These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, CA. yniihara@rei.edu

ABSTRACT
BACKGROUND: Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). METHODS: Five patients (two men and three women, mean age 40 ± 15 years, range 24-58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. RESULTS: The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). CONCLUSIONS: These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia.

No MeSH data available.


Related in: MedlinePlus

Heinz body (%) from blood samples at entry and 4 weeks follow-up.
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Figure 1: Heinz body (%) from blood samples at entry and 4 weeks follow-up.

Mentions: Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) were entered into the study. Table 1 summarizes the hematological data, RBC glutamine content, and the results of the Heinz body analysis at baseline and after 4 weeks of administration of AGE. (Figure 1) There were no significant changes in RBC count, hemoglobin level, hematocrit or reticulocyte count. However, the average Heinz body count decreased from 58.9 to 29.8 percent (P < .03). In all patients, the average Heinz body count decreased significantly at 4 weeks compared to the baseline.


Aged garlic extract therapy for sickle cell anemia patients.

Takasu J, Uykimpang R, Sunga M, Amagase H, Niihara Y - BMC Blood Disord (2002)

Heinz body (%) from blood samples at entry and 4 weeks follow-up.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC117242&req=5

Figure 1: Heinz body (%) from blood samples at entry and 4 weeks follow-up.
Mentions: Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) were entered into the study. Table 1 summarizes the hematological data, RBC glutamine content, and the results of the Heinz body analysis at baseline and after 4 weeks of administration of AGE. (Figure 1) There were no significant changes in RBC count, hemoglobin level, hematocrit or reticulocyte count. However, the average Heinz body count decreased from 58.9 to 29.8 percent (P < .03). In all patients, the average Heinz body count decreased significantly at 4 weeks compared to the baseline.

Bottom Line: With this disorder oxidative, phenomena play a significant role in its pathophysiology.In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 &PlusMinus; 20.0% at baseline to 29.8 &PlusMinus; 15.3% at follow-up, p = 0.03).CONCLUSIONS: These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, CA. yniihara@rei.edu

ABSTRACT
BACKGROUND: Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). METHODS: Five patients (two men and three women, mean age 40 ± 15 years, range 24-58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. RESULTS: The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). CONCLUSIONS: These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia.

No MeSH data available.


Related in: MedlinePlus