Limits...
Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers.

Willemse BW, ten Hacken NH, Rutgers B, Postma DS, Timens W - Respir. Res. (2005)

Bottom Line: Inflammation in the airways and lung parenchyma underlies fixed airway obstruction in chronic obstructive pulmonary disease.Neutrophil percentage, interleukin-8 and eosinophilic-cationic-protein levels in sputum were higher in chronic obstructive pulmonary disease (stage I-III) than asymptomatic smokers.This may have implications for future studies, which should avoid including mixed populations of smokers and ex-smokers.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands. willemse@path.umcg.nl

ABSTRACT

Background: Inflammation in the airways and lung parenchyma underlies fixed airway obstruction in chronic obstructive pulmonary disease. The exact role of smoking as promoting factor of inflammation in chronic obstructive pulmonary disease is not clear, partly because studies often do not distinguish between current and ex-smokers.

Methods: We investigated airway inflammation in sputum and bronchial biopsies of 34 smokers with chronic obstructive pulmonary disease (9 Global initiative for Chronic Obstructive Lung Disease stage 0, 9 stage I, 10 stage II and 6 stage III) and 26 asymptomatic smokers, and its relationship with past and present smoking habits and airway obstruction.

Results: Neutrophil percentage, interleukin-8 and eosinophilic-cationic-protein levels in sputum were higher in chronic obstructive pulmonary disease (stage I-III) than asymptomatic smokers. Inflammatory cell numbers in bronchial biopsies were similar in both groups. Current smoking correlated positively with macrophages: in bronchial biopsies in both groups, and in sputum in chronic obstructive pulmonary disease. Pack-years smoking correlated positively with biopsy macrophages only in chronic obstructive pulmonary disease.

Conclusion: Inflammatory effects of current smoking may mask the underlying ongoing inflammatory process pertinent to chronic obstructive pulmonary disease. This may have implications for future studies, which should avoid including mixed populations of smokers and ex-smokers.

Show MeSH

Related in: MedlinePlus

Spearman's rank correlation: Cigarettes smoked per day and percentage of macrophages in biopsies. COPD (■, ): rho = 0.69 p = 0.002 and asymptomatic smokers(□, ): rho = 0.46 p = 0.03.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC1140754&req=5

Figure 2: Spearman's rank correlation: Cigarettes smoked per day and percentage of macrophages in biopsies. COPD (■, ): rho = 0.69 p = 0.002 and asymptomatic smokers(□, ): rho = 0.46 p = 0.03.

Mentions: The number of cigarettes smoked per day correlated negatively with neutrophils and positively with macrophages in sputum, which was significant in COPD (table 3, figure 1). The number of cigarettes smoked per day correlated positively with macrophages in bronchial biopsies, in both groups (table 3, figure 2). In asymptomatic smokers, the number of cigarettes per day correlated negatively with the number and percentage of eosinophils in sputum. In COPD the number of cigarettes smoked per day correlated negatively with eosinophil area in bronchial biopsies (table 3).


Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers.

Willemse BW, ten Hacken NH, Rutgers B, Postma DS, Timens W - Respir. Res. (2005)

Spearman's rank correlation: Cigarettes smoked per day and percentage of macrophages in biopsies. COPD (■, ): rho = 0.69 p = 0.002 and asymptomatic smokers(□, ): rho = 0.46 p = 0.03.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1140754&req=5

Figure 2: Spearman's rank correlation: Cigarettes smoked per day and percentage of macrophages in biopsies. COPD (■, ): rho = 0.69 p = 0.002 and asymptomatic smokers(□, ): rho = 0.46 p = 0.03.
Mentions: The number of cigarettes smoked per day correlated negatively with neutrophils and positively with macrophages in sputum, which was significant in COPD (table 3, figure 1). The number of cigarettes smoked per day correlated positively with macrophages in bronchial biopsies, in both groups (table 3, figure 2). In asymptomatic smokers, the number of cigarettes per day correlated negatively with the number and percentage of eosinophils in sputum. In COPD the number of cigarettes smoked per day correlated negatively with eosinophil area in bronchial biopsies (table 3).

Bottom Line: Inflammation in the airways and lung parenchyma underlies fixed airway obstruction in chronic obstructive pulmonary disease.Neutrophil percentage, interleukin-8 and eosinophilic-cationic-protein levels in sputum were higher in chronic obstructive pulmonary disease (stage I-III) than asymptomatic smokers.This may have implications for future studies, which should avoid including mixed populations of smokers and ex-smokers.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands. willemse@path.umcg.nl

ABSTRACT

Background: Inflammation in the airways and lung parenchyma underlies fixed airway obstruction in chronic obstructive pulmonary disease. The exact role of smoking as promoting factor of inflammation in chronic obstructive pulmonary disease is not clear, partly because studies often do not distinguish between current and ex-smokers.

Methods: We investigated airway inflammation in sputum and bronchial biopsies of 34 smokers with chronic obstructive pulmonary disease (9 Global initiative for Chronic Obstructive Lung Disease stage 0, 9 stage I, 10 stage II and 6 stage III) and 26 asymptomatic smokers, and its relationship with past and present smoking habits and airway obstruction.

Results: Neutrophil percentage, interleukin-8 and eosinophilic-cationic-protein levels in sputum were higher in chronic obstructive pulmonary disease (stage I-III) than asymptomatic smokers. Inflammatory cell numbers in bronchial biopsies were similar in both groups. Current smoking correlated positively with macrophages: in bronchial biopsies in both groups, and in sputum in chronic obstructive pulmonary disease. Pack-years smoking correlated positively with biopsy macrophages only in chronic obstructive pulmonary disease.

Conclusion: Inflammatory effects of current smoking may mask the underlying ongoing inflammatory process pertinent to chronic obstructive pulmonary disease. This may have implications for future studies, which should avoid including mixed populations of smokers and ex-smokers.

Show MeSH
Related in: MedlinePlus