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Worldwide trends in mortality from biliary tract malignancies.

Patel T - BMC Cancer (2002)

Bottom Line: The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 +/- 1.5, and for females was 5.1 +/- 1.0.Increased mortality rates were observed in all geographic regions.Within Europe, increases were higher in Western Europe than in Central or Northern Europe.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Gastroenterology Scott and White Memorial Hospital and Clinic Texas A&M University System Health Science Center College of Medicine Temple, TX, USA. tpatel@medicine.tamu.edu

ABSTRACT

Background: Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies.

Methods: Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates.

Results: An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 +/- 1.5, and for females was 5.1 +/- 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 +/- 0.4 for males, but -1.3 +/- 0.4 for females.

Conclusions: There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.

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Related in: MedlinePlus

Regional differences in the mean estimated annual percent change in age-adjusted (1970 World Standard population) gender-specific mortality rates from intrahepatic biliary tract tumors (top) and gall-bladder and extra-hepatic biliary tract tumors (bottom).
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Figure 1: Regional differences in the mean estimated annual percent change in age-adjusted (1970 World Standard population) gender-specific mortality rates from intrahepatic biliary tract tumors (top) and gall-bladder and extra-hepatic biliary tract tumors (bottom).

Mentions: An overall increase in mortality was observed in all regions, with the greatest increases in the Americas, Oceania and Western Europe (Figure 1). The increase in EAPC in these regions was similar to that which we have recently reported in the United States [6]. However, regional differences were noticed in Europe, with lower reported increases in EAPC in Central and Northern Europe. The EAPC was lower for Asia/Middle East, although data from regions of known high incidence of intrahepatic cholangiocarcinoma such as Thailand and other southeastern nations were not included in this analysis. Thus, there has been a global increase in mortality related to intrahepatic cholangiocarcinoma in regions of low disease prevalence.


Worldwide trends in mortality from biliary tract malignancies.

Patel T - BMC Cancer (2002)

Regional differences in the mean estimated annual percent change in age-adjusted (1970 World Standard population) gender-specific mortality rates from intrahepatic biliary tract tumors (top) and gall-bladder and extra-hepatic biliary tract tumors (bottom).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC113759&req=5

Figure 1: Regional differences in the mean estimated annual percent change in age-adjusted (1970 World Standard population) gender-specific mortality rates from intrahepatic biliary tract tumors (top) and gall-bladder and extra-hepatic biliary tract tumors (bottom).
Mentions: An overall increase in mortality was observed in all regions, with the greatest increases in the Americas, Oceania and Western Europe (Figure 1). The increase in EAPC in these regions was similar to that which we have recently reported in the United States [6]. However, regional differences were noticed in Europe, with lower reported increases in EAPC in Central and Northern Europe. The EAPC was lower for Asia/Middle East, although data from regions of known high incidence of intrahepatic cholangiocarcinoma such as Thailand and other southeastern nations were not included in this analysis. Thus, there has been a global increase in mortality related to intrahepatic cholangiocarcinoma in regions of low disease prevalence.

Bottom Line: The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 +/- 1.5, and for females was 5.1 +/- 1.0.Increased mortality rates were observed in all geographic regions.Within Europe, increases were higher in Western Europe than in Central or Northern Europe.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Gastroenterology Scott and White Memorial Hospital and Clinic Texas A&M University System Health Science Center College of Medicine Temple, TX, USA. tpatel@medicine.tamu.edu

ABSTRACT

Background: Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies.

Methods: Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates.

Results: An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 +/- 1.5, and for females was 5.1 +/- 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 +/- 0.4 for males, but -1.3 +/- 0.4 for females.

Conclusions: There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.

Show MeSH
Related in: MedlinePlus