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Prevalence of oropharyngeal beta-lactamase-producing Capnocytophaga spp. in pediatric oncology patients over a ten-year period.

Jolivet-Gougeon A, Tamanai-Shacoori Z, Desbordes L, Gandemer V, Sixou JL, Morvan-Graveline N, Cormier M, Bonnaure-Mallet M - BMC Infect. Dis. (2005)

Bottom Line: A total of 440 strains of Capnocytophaga spp. were isolated, 309 (70%) of which were beta-lactamase producers.The beta-lactamase-producing strains were all resistant to cefazolin, 86% to amoxicillin, and 63% to ceftazidime.The proportion of strains resistant to third-generation cephalosporins remained high throughout the ten-year study, while susceptibility to imipenem and amoxicillin combined with clavulanic acid was always conserved.

View Article: PubMed Central - HTML - PubMed

Affiliation: Equipe de Microbiologie, UPRES-EA 1254, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France. anne.gougeon@univ-rennes1.fr

ABSTRACT

Background: The aim of this study was to evaluate the prevalence of beta-lactamase-producing Capnocytophaga isolates in young children hospitalized in the Pediatric Oncology Department of Hôpital Sud (Rennes, France) over a ten-year period (1993-2002).

Methods: In neutropenic children, a periodic survey of the oral cavity allows a predictive evaluation of the risk of systemic infections by Capnocytophaga spp. In 449 children with cancer, 3,053 samples were collected by oral swabbing and plated on TBBP agar. The susceptibility of Capnocytophaga isolates to five beta-lactams was determined.

Results: A total of 440 strains of Capnocytophaga spp. were isolated, 309 (70%) of which were beta-lactamase producers. The beta-lactamase-producing strains were all resistant to cefazolin, 86% to amoxicillin, and 63% to ceftazidime. The proportion of strains resistant to third-generation cephalosporins remained high throughout the ten-year study, while susceptibility to imipenem and amoxicillin combined with clavulanic acid was always conserved.

Conclusion: These results highlight the risk of antibiotic failure in Capnocytophaga infections and the importance of monitoring immunosuppressed patients and testing for antibiotic susceptibility and beta-lactamase production.

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Related in: MedlinePlus

Prevalence of beta-lactamase producing Capnocytophaga spp. strains in periodic oral samples from children hospitalized in the Pediatric Oncology Department of Hôpital Sud (Rennes, France) from 1993 to 2002.
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Figure 1: Prevalence of beta-lactamase producing Capnocytophaga spp. strains in periodic oral samples from children hospitalized in the Pediatric Oncology Department of Hôpital Sud (Rennes, France) from 1993 to 2002.

Mentions: Whatever the number of isolates, there was a high prevalence of beta-lactamase-producing strains (70%), with a varying incidence from 54% in 1996 (based on three out of 49 children) to 78% in 1995 (similarly, 11/14 isolates describes 8/45 children) (Figures 1 and 2). The susceptibility of Capnocytophaga strains was always conserved with imipenem (MIC < 4 μg/ml) and amoxicillin combined with clavulanic acid (MIC < 4/2 μg/ml). All beta-lactamase producing strains were uniformly resistant to cefazolin (MIC > 8 μg/ml), but the authors noted different levels of resistance to amoxicillin and ceftazidime (Table 2).


Prevalence of oropharyngeal beta-lactamase-producing Capnocytophaga spp. in pediatric oncology patients over a ten-year period.

Jolivet-Gougeon A, Tamanai-Shacoori Z, Desbordes L, Gandemer V, Sixou JL, Morvan-Graveline N, Cormier M, Bonnaure-Mallet M - BMC Infect. Dis. (2005)

Prevalence of beta-lactamase producing Capnocytophaga spp. strains in periodic oral samples from children hospitalized in the Pediatric Oncology Department of Hôpital Sud (Rennes, France) from 1993 to 2002.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC1131902&req=5

Figure 1: Prevalence of beta-lactamase producing Capnocytophaga spp. strains in periodic oral samples from children hospitalized in the Pediatric Oncology Department of Hôpital Sud (Rennes, France) from 1993 to 2002.
Mentions: Whatever the number of isolates, there was a high prevalence of beta-lactamase-producing strains (70%), with a varying incidence from 54% in 1996 (based on three out of 49 children) to 78% in 1995 (similarly, 11/14 isolates describes 8/45 children) (Figures 1 and 2). The susceptibility of Capnocytophaga strains was always conserved with imipenem (MIC < 4 μg/ml) and amoxicillin combined with clavulanic acid (MIC < 4/2 μg/ml). All beta-lactamase producing strains were uniformly resistant to cefazolin (MIC > 8 μg/ml), but the authors noted different levels of resistance to amoxicillin and ceftazidime (Table 2).

Bottom Line: A total of 440 strains of Capnocytophaga spp. were isolated, 309 (70%) of which were beta-lactamase producers.The beta-lactamase-producing strains were all resistant to cefazolin, 86% to amoxicillin, and 63% to ceftazidime.The proportion of strains resistant to third-generation cephalosporins remained high throughout the ten-year study, while susceptibility to imipenem and amoxicillin combined with clavulanic acid was always conserved.

View Article: PubMed Central - HTML - PubMed

Affiliation: Equipe de Microbiologie, UPRES-EA 1254, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France. anne.gougeon@univ-rennes1.fr

ABSTRACT

Background: The aim of this study was to evaluate the prevalence of beta-lactamase-producing Capnocytophaga isolates in young children hospitalized in the Pediatric Oncology Department of Hôpital Sud (Rennes, France) over a ten-year period (1993-2002).

Methods: In neutropenic children, a periodic survey of the oral cavity allows a predictive evaluation of the risk of systemic infections by Capnocytophaga spp. In 449 children with cancer, 3,053 samples were collected by oral swabbing and plated on TBBP agar. The susceptibility of Capnocytophaga isolates to five beta-lactams was determined.

Results: A total of 440 strains of Capnocytophaga spp. were isolated, 309 (70%) of which were beta-lactamase producers. The beta-lactamase-producing strains were all resistant to cefazolin, 86% to amoxicillin, and 63% to ceftazidime. The proportion of strains resistant to third-generation cephalosporins remained high throughout the ten-year study, while susceptibility to imipenem and amoxicillin combined with clavulanic acid was always conserved.

Conclusion: These results highlight the risk of antibiotic failure in Capnocytophaga infections and the importance of monitoring immunosuppressed patients and testing for antibiotic susceptibility and beta-lactamase production.

Show MeSH
Related in: MedlinePlus