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On the number of New World founders: a population genetic portrait of the peopling of the Americas.

Hey J - PLoS Biol. (2005)

Bottom Line: The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow.The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population.Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA. hey@biology.rutgers.edu

ABSTRACT
The founding of New World populations by Asian peoples is the focus of considerable archaeological and genetic research, and there persist important questions on when and how these events occurred. Genetic data offer great potential for the study of human population history, but there are significant challenges in discerning distinct demographic processes. A new method for the study of diverging populations was applied to questions on the founding and history of Amerind-speaking Native American populations. The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow. Analyses of data from nine loci are consistent with the general portrait that has emerged from archaeological and other kinds of evidence. The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population. By adding a splitting parameter to population divergence models it becomes possible to develop detailed portraits of human demographic history. Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.

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Approximate Geographic Locations, and Sample Sizes per location, for Each Locus Listed in Table 1In some cases locations are based on actual geographic locations, in other cases the locations are the approximate center of the geographic region occupied by ethnic groups identified in the original references (Table 1).
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pbio-0030193-g002: Approximate Geographic Locations, and Sample Sizes per location, for Each Locus Listed in Table 1In some cases locations are based on actual geographic locations, in other cases the locations are the approximate center of the geographic region occupied by ethnic groups identified in the original references (Table 1).

Mentions: These models were applied to questions on the founding of New World populations from Asia. A total of nine DNA sequence datasets that included Asian and Native American (Amerind-speaking) samples were drawn from the literature (Figure 2 and Table 1) and analyzed jointly using a procedure that provides posterior probability distributions for each of the model parameters [30,33]. The stochastic variance among loci is clearly evident in the variation of FST values (between Asian and New World samples) observed among the loci. Of the nine loci included in the present study, three have fairly high FST values, while the remainder are either negative (undefined) or near zero (Table 1).


On the number of New World founders: a population genetic portrait of the peopling of the Americas.

Hey J - PLoS Biol. (2005)

Approximate Geographic Locations, and Sample Sizes per location, for Each Locus Listed in Table 1In some cases locations are based on actual geographic locations, in other cases the locations are the approximate center of the geographic region occupied by ethnic groups identified in the original references (Table 1).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1131883&req=5

pbio-0030193-g002: Approximate Geographic Locations, and Sample Sizes per location, for Each Locus Listed in Table 1In some cases locations are based on actual geographic locations, in other cases the locations are the approximate center of the geographic region occupied by ethnic groups identified in the original references (Table 1).
Mentions: These models were applied to questions on the founding of New World populations from Asia. A total of nine DNA sequence datasets that included Asian and Native American (Amerind-speaking) samples were drawn from the literature (Figure 2 and Table 1) and analyzed jointly using a procedure that provides posterior probability distributions for each of the model parameters [30,33]. The stochastic variance among loci is clearly evident in the variation of FST values (between Asian and New World samples) observed among the loci. Of the nine loci included in the present study, three have fairly high FST values, while the remainder are either negative (undefined) or near zero (Table 1).

Bottom Line: The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow.The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population.Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA. hey@biology.rutgers.edu

ABSTRACT
The founding of New World populations by Asian peoples is the focus of considerable archaeological and genetic research, and there persist important questions on when and how these events occurred. Genetic data offer great potential for the study of human population history, but there are significant challenges in discerning distinct demographic processes. A new method for the study of diverging populations was applied to questions on the founding and history of Amerind-speaking Native American populations. The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow. Analyses of data from nine loci are consistent with the general portrait that has emerged from archaeological and other kinds of evidence. The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population. By adding a splitting parameter to population divergence models it becomes possible to develop detailed portraits of human demographic history. Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.

Show MeSH