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An Increased Risk of Osteoporosis during Acquired Immunodeficiency Syndrome.

Annapoorna N, Rao GV, Reddy NS, Rambabu P, Rao KR - Int J Med Sci (2004)

Bottom Line: The etiology of this occurrence in HIV infections is controversial.This problem seems to be more frequent in patients receiving potent antiretroviral therapy.The biochemical markers also aid in this assessment.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biotechnology, Acharya Nagarjuna University, Nagarjunanagar, Guntur- 522 510, A.P., India.

ABSTRACT
Osteoporosis is characterized by decreased bone mineral density and mechanistic imbalances of bone tissue that may result in reduced skeletal strength and an enhanced susceptibility to fractures. Osteoporosis in its most common form affects the elderly (both sexes) and all racial groups of human beings. Multiple environmental risk factors like acquired immune deficiency syndrome (AIDS) are believed to be one of the causes of osteoporosis. Recently a high incidence of osteoporosis has been observed in human immunodeficiency virus (HIV) infected individuals. The etiology of this occurrence in HIV infections is controversial. This problem seems to be more frequent in patients receiving potent antiretroviral therapy. In AIDS, the main suggested risk factors for the development of osteoporosis are use of protease inhibitors, longer duration of HIV infection, lower body weight before antiretroviral therapy, high viral load. Variations in serum parameters like osteocalcin, c-telopeptide, levels of elements like Calcium, Magnesium, Phosphorus, concentration of vitamin-D metabolites, lactate levels, bicarbonate concentrations, amount of alkaline phosphatase are demonstrated in the course of development of osteoporosis. OPG/RANKL/RANK system is final mediator of bone remodeling. Bone mineral density (BMD) test is of added value to assess the risk of osteoporosis in patients infected with AIDS. The biochemical markers also aid in this assessment. Clinical management mostly follows the lines of treatment of osteoporosis and osteopenia.

No MeSH data available.


Related in: MedlinePlus

Schema of the object of environmental and genetic risk factors on the interaction between bone strength and trauma that leads to osteoporotic fracture. Source of Fig. - Reference 29
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Figure 1: Schema of the object of environmental and genetic risk factors on the interaction between bone strength and trauma that leads to osteoporotic fracture. Source of Fig. - Reference 29

Mentions: The risk factors for osteoporosis are fairly straight forward (fig 1).


An Increased Risk of Osteoporosis during Acquired Immunodeficiency Syndrome.

Annapoorna N, Rao GV, Reddy NS, Rambabu P, Rao KR - Int J Med Sci (2004)

Schema of the object of environmental and genetic risk factors on the interaction between bone strength and trauma that leads to osteoporotic fracture. Source of Fig. - Reference 29
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1074710&req=5

Figure 1: Schema of the object of environmental and genetic risk factors on the interaction between bone strength and trauma that leads to osteoporotic fracture. Source of Fig. - Reference 29
Mentions: The risk factors for osteoporosis are fairly straight forward (fig 1).

Bottom Line: The etiology of this occurrence in HIV infections is controversial.This problem seems to be more frequent in patients receiving potent antiretroviral therapy.The biochemical markers also aid in this assessment.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biotechnology, Acharya Nagarjuna University, Nagarjunanagar, Guntur- 522 510, A.P., India.

ABSTRACT
Osteoporosis is characterized by decreased bone mineral density and mechanistic imbalances of bone tissue that may result in reduced skeletal strength and an enhanced susceptibility to fractures. Osteoporosis in its most common form affects the elderly (both sexes) and all racial groups of human beings. Multiple environmental risk factors like acquired immune deficiency syndrome (AIDS) are believed to be one of the causes of osteoporosis. Recently a high incidence of osteoporosis has been observed in human immunodeficiency virus (HIV) infected individuals. The etiology of this occurrence in HIV infections is controversial. This problem seems to be more frequent in patients receiving potent antiretroviral therapy. In AIDS, the main suggested risk factors for the development of osteoporosis are use of protease inhibitors, longer duration of HIV infection, lower body weight before antiretroviral therapy, high viral load. Variations in serum parameters like osteocalcin, c-telopeptide, levels of elements like Calcium, Magnesium, Phosphorus, concentration of vitamin-D metabolites, lactate levels, bicarbonate concentrations, amount of alkaline phosphatase are demonstrated in the course of development of osteoporosis. OPG/RANKL/RANK system is final mediator of bone remodeling. Bone mineral density (BMD) test is of added value to assess the risk of osteoporosis in patients infected with AIDS. The biochemical markers also aid in this assessment. Clinical management mostly follows the lines of treatment of osteoporosis and osteopenia.

No MeSH data available.


Related in: MedlinePlus