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Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus.

Pimenta FJ, Pinheiro MD, Gomez RS - Int J Med Sci (2004)

Bottom Line: It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa.Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive.Ten cases of normal mucosa were added to the control group.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

ABSTRACT
Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA mismatch repair (hMMR) genes and it plays an important role in reducing mutation and maintaining genomic stability. hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma. In this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium. We examined the expression of hMSH2 protein by immunohistochemistry in twenty-six cases of oral lichen planus. Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive. Ten cases of normal mucosa were added to the control group. Results showed that the percentage of positive cells to hMSH2 was smaller in reticular (46.54%; p=0,006) and atrophic/erosive (48.79%; p=0,028) subtypes of oral lichen planus compared to normal mucosa (61.29%). The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more susceptible to mutation and therefore facilitate the development of oral squamous cell carcinoma.

No MeSH data available.


Related in: MedlinePlus

Increased labelling of hMSH2 protein in basal and intermediate epithelial layers of normal oral mucosa (streptavidin-biotin amplified system, x 400).
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Figure 2: Increased labelling of hMSH2 protein in basal and intermediate epithelial layers of normal oral mucosa (streptavidin-biotin amplified system, x 400).

Mentions: The hMSH2 immunoreativity was detected mainly in basal and intermediate epithelial layers (Fig. 1 and 2). The mean percentage of positive epithelial cells to hMSH2 in OLP and oral normal mucosa were listed in table 1. The percentage of positive cells in reticular and atrophic/erosive subtypes of OLP was significantly decreased compared to oral normal mucosa (Table 1). No difference was detected between the reticular and atrophic/erosive subtypes.


Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus.

Pimenta FJ, Pinheiro MD, Gomez RS - Int J Med Sci (2004)

Increased labelling of hMSH2 protein in basal and intermediate epithelial layers of normal oral mucosa (streptavidin-biotin amplified system, x 400).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1074709&req=5

Figure 2: Increased labelling of hMSH2 protein in basal and intermediate epithelial layers of normal oral mucosa (streptavidin-biotin amplified system, x 400).
Mentions: The hMSH2 immunoreativity was detected mainly in basal and intermediate epithelial layers (Fig. 1 and 2). The mean percentage of positive epithelial cells to hMSH2 in OLP and oral normal mucosa were listed in table 1. The percentage of positive cells in reticular and atrophic/erosive subtypes of OLP was significantly decreased compared to oral normal mucosa (Table 1). No difference was detected between the reticular and atrophic/erosive subtypes.

Bottom Line: It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa.Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive.Ten cases of normal mucosa were added to the control group.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

ABSTRACT
Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA mismatch repair (hMMR) genes and it plays an important role in reducing mutation and maintaining genomic stability. hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma. In this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium. We examined the expression of hMSH2 protein by immunohistochemistry in twenty-six cases of oral lichen planus. Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive. Ten cases of normal mucosa were added to the control group. Results showed that the percentage of positive cells to hMSH2 was smaller in reticular (46.54%; p=0,006) and atrophic/erosive (48.79%; p=0,028) subtypes of oral lichen planus compared to normal mucosa (61.29%). The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more susceptible to mutation and therefore facilitate the development of oral squamous cell carcinoma.

No MeSH data available.


Related in: MedlinePlus