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The Systemic Theory of Living Systems and Relevance to CAM: Part I: The Theory.

Olalde Rangel JA - Evid Based Complement Alternat Med (2005)

Bottom Line: Energy-stimulating phytomedicines increase available energy and decrease total entropy of an open biological system by providing negative entropy.SM postulates that the state of health, H, of an individual, is effectively equal to the product of the strength of each factor H = O x E x I.SM observes that when all three factors are brought back to ideal levels, patients' conditions begin the recovery to normal health.

View Article: PubMed Central - PubMed

ABSTRACT
The Systemic Theory of Living Systems is being published in several parts in eCAM. The theory is axiomatic. It originates from the phenomenological idea that physiological health is based on three factors: integrity of its structure or organization, O, functional organic energy reserve, E, and level of active biological intelligence, I. From the theory is derived a treatment strategy called Systemic Medicine (SM). This is based on identifying and prescribing phytomedicines and/or other medications that strengthen each factor. Energy-stimulating phytomedicines increase available energy and decrease total entropy of an open biological system by providing negative entropy. The same occurs with phytomedicines that act as biological intelligence modulators. They should be used as the first line of treatment in all ailments, since all pathologies, by definition, imply a higher than normal organic entropy. SM postulates that the state of health, H, of an individual, is effectively equal to the product of the strength of each factor H = O x E x I. SM observes that when all three factors are brought back to ideal levels, patients' conditions begin the recovery to normal health.

No MeSH data available.


Related in: MedlinePlus

Ginsenoside energizing mechanism. Intracellular action mechanism of Panax ginseng that results in stimulation of ATP synthesis whose hydrolysis produces energy.
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fig5: Ginsenoside energizing mechanism. Intracellular action mechanism of Panax ginseng that results in stimulation of ATP synthesis whose hydrolysis produces energy.

Mentions: Panax active principles are bonded to beta-adrenoceptors in the cellular membrane (Fig 4). This triggrers a secondary transmitting message system (cyclic AMP), the signal travels through a transducer pathway to the mitochondria to increase activity of MDH, SDH and CTS, enzymes of the glycolysis or tricarboxylic acid cycle. ATP generation is thus increased, raising energy levels using glucose as fuel, as shown in Figure 5. Moreover ginsenosides, such as the sulfonylureas, are insulin secretagogues (I stimulators) since they help regulate blood glucose levels by directly stimulating first-phase insulin secretion in the pancreatic beta cells (O). These cells are responsible for sensing and secreting appropriate amounts of insulin in response to a glucose stimulus. Mitochondrial glucose metabolism leads to ATP generation and increases intracellular ratios of ATP/ADP, which result in closure of the ATP-sensitive potassium channel (KATP; a 140 kDa membrane protein) on the plasma membrane. Closure of this channel depolarizes the membrane and triggers opening of voltage-sensitive calcium channels, leading to the rapid influx of calcium. Increased intracellular calcium causes an alteration in the cytoskeleton and stimulates translocation of insulin-containing secretor granules to the plasma membrane and the exocytotic release of insulin. Either an increase in the ATP/ADP ratio or binding of ginsenosides to cell membrane receptors results in the closure of the KATP channel and insulin secretion (21). This is depicted in Figure 6. As a corollary, with increasing energy we obtain a significantly larger health triangle because the system's intelligence has acquired more capacity to organize. Panax ginseng provides an example of a phytomedicine capable of enhancing I, E and O simultaneously in the living system.


The Systemic Theory of Living Systems and Relevance to CAM: Part I: The Theory.

Olalde Rangel JA - Evid Based Complement Alternat Med (2005)

Ginsenoside energizing mechanism. Intracellular action mechanism of Panax ginseng that results in stimulation of ATP synthesis whose hydrolysis produces energy.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1062161&req=5

fig5: Ginsenoside energizing mechanism. Intracellular action mechanism of Panax ginseng that results in stimulation of ATP synthesis whose hydrolysis produces energy.
Mentions: Panax active principles are bonded to beta-adrenoceptors in the cellular membrane (Fig 4). This triggrers a secondary transmitting message system (cyclic AMP), the signal travels through a transducer pathway to the mitochondria to increase activity of MDH, SDH and CTS, enzymes of the glycolysis or tricarboxylic acid cycle. ATP generation is thus increased, raising energy levels using glucose as fuel, as shown in Figure 5. Moreover ginsenosides, such as the sulfonylureas, are insulin secretagogues (I stimulators) since they help regulate blood glucose levels by directly stimulating first-phase insulin secretion in the pancreatic beta cells (O). These cells are responsible for sensing and secreting appropriate amounts of insulin in response to a glucose stimulus. Mitochondrial glucose metabolism leads to ATP generation and increases intracellular ratios of ATP/ADP, which result in closure of the ATP-sensitive potassium channel (KATP; a 140 kDa membrane protein) on the plasma membrane. Closure of this channel depolarizes the membrane and triggers opening of voltage-sensitive calcium channels, leading to the rapid influx of calcium. Increased intracellular calcium causes an alteration in the cytoskeleton and stimulates translocation of insulin-containing secretor granules to the plasma membrane and the exocytotic release of insulin. Either an increase in the ATP/ADP ratio or binding of ginsenosides to cell membrane receptors results in the closure of the KATP channel and insulin secretion (21). This is depicted in Figure 6. As a corollary, with increasing energy we obtain a significantly larger health triangle because the system's intelligence has acquired more capacity to organize. Panax ginseng provides an example of a phytomedicine capable of enhancing I, E and O simultaneously in the living system.

Bottom Line: Energy-stimulating phytomedicines increase available energy and decrease total entropy of an open biological system by providing negative entropy.SM postulates that the state of health, H, of an individual, is effectively equal to the product of the strength of each factor H = O x E x I.SM observes that when all three factors are brought back to ideal levels, patients' conditions begin the recovery to normal health.

View Article: PubMed Central - PubMed

ABSTRACT
The Systemic Theory of Living Systems is being published in several parts in eCAM. The theory is axiomatic. It originates from the phenomenological idea that physiological health is based on three factors: integrity of its structure or organization, O, functional organic energy reserve, E, and level of active biological intelligence, I. From the theory is derived a treatment strategy called Systemic Medicine (SM). This is based on identifying and prescribing phytomedicines and/or other medications that strengthen each factor. Energy-stimulating phytomedicines increase available energy and decrease total entropy of an open biological system by providing negative entropy. The same occurs with phytomedicines that act as biological intelligence modulators. They should be used as the first line of treatment in all ailments, since all pathologies, by definition, imply a higher than normal organic entropy. SM postulates that the state of health, H, of an individual, is effectively equal to the product of the strength of each factor H = O x E x I. SM observes that when all three factors are brought back to ideal levels, patients' conditions begin the recovery to normal health.

No MeSH data available.


Related in: MedlinePlus