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Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties.

Naser B, Bodinet C, Tegtmeier M, Lindequist U - Evid Based Complement Alternat Med (2005)

Bottom Line: Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data.This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant.Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations.

View Article: PubMed Central - PubMed

ABSTRACT
Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections.

No MeSH data available.


Related in: MedlinePlus

Increase in the NO2 production of alveolar macrophages through the retentate fraction from Thuja occidentalis herba (100, 10 and 1 μg/ml). Positive control substance: LPS (5 ng/ml) + IFN-γ (1 ng/ml). Data are expressed as the mean value ± SD (n = 4).
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fig5: Increase in the NO2 production of alveolar macrophages through the retentate fraction from Thuja occidentalis herba (100, 10 and 1 μg/ml). Positive control substance: LPS (5 ng/ml) + IFN-γ (1 ng/ml). Data are expressed as the mean value ± SD (n = 4).

Mentions: The influence of Thujae occidentalis herba on the oxidative metabolism of macrophages was determined by measuring the NO2− production of mouse alveolar macrophages (MH-S) after 48 h incubation with the respective test fractions. The NO2− production of the MH-S cells was increased by incubation with the retentate fraction in a concentration-dependent fashion from 2 ± 0.3 μmol/l (medium control) to a maximum of 42.5 ± 2.7 μmol/l. The combined addition of IFN and LPS (1 + 5 ng/ml) served as a positive control in this test system (Fig. 5) (38).


Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties.

Naser B, Bodinet C, Tegtmeier M, Lindequist U - Evid Based Complement Alternat Med (2005)

Increase in the NO2 production of alveolar macrophages through the retentate fraction from Thuja occidentalis herba (100, 10 and 1 μg/ml). Positive control substance: LPS (5 ng/ml) + IFN-γ (1 ng/ml). Data are expressed as the mean value ± SD (n = 4).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1062158&req=5

fig5: Increase in the NO2 production of alveolar macrophages through the retentate fraction from Thuja occidentalis herba (100, 10 and 1 μg/ml). Positive control substance: LPS (5 ng/ml) + IFN-γ (1 ng/ml). Data are expressed as the mean value ± SD (n = 4).
Mentions: The influence of Thujae occidentalis herba on the oxidative metabolism of macrophages was determined by measuring the NO2− production of mouse alveolar macrophages (MH-S) after 48 h incubation with the respective test fractions. The NO2− production of the MH-S cells was increased by incubation with the retentate fraction in a concentration-dependent fashion from 2 ± 0.3 μmol/l (medium control) to a maximum of 42.5 ± 2.7 μmol/l. The combined addition of IFN and LPS (1 + 5 ng/ml) served as a positive control in this test system (Fig. 5) (38).

Bottom Line: Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data.This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant.Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations.

View Article: PubMed Central - PubMed

ABSTRACT
Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections.

No MeSH data available.


Related in: MedlinePlus