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Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties.

Naser B, Bodinet C, Tegtmeier M, Lindequist U - Evid Based Complement Alternat Med (2005)

Bottom Line: Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data.This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant.Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations.

View Article: PubMed Central - PubMed

ABSTRACT
Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections.

No MeSH data available.


Related in: MedlinePlus

The solvent for extraction significantly influences the amount of thujone in the extracts of the dried herbal substance Thujae occidentalis herba.
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fig4: The solvent for extraction significantly influences the amount of thujone in the extracts of the dried herbal substance Thujae occidentalis herba.

Mentions: A critical factor for Thuja's use as a medicinal herb is its content of essential oil. Indeed, the content of thujone seems to be significantly affected by different extraction procedures. The highest content of essential oil was found in extracts obtained by distillation, whilst percolation with purified water reduced the thujone content in the extract to the lowest level (29). Using purified water as a solvent, an average of 0.6 mg of thujone was extracted from 1 g of drug during percolation (30). In contrast, when 30% (v/v) ethanol was used, 2.8 mg of thujone was extracted from 1 g of Thujae occidentalis herba, and >2.5-fold higher amounts of thujone (7.9 mg) were attained with high ethanol concentration (90% v/v) (30). From the result of 12 batches, the mean value for the thujone content was 1.16 mg/g of herbal substance and the maximum value was 2.95 mg/g, corresponding to 0.30%. Using a special extraction procedure with 30% (v/v) ethanol, the content of thujone in the extract can be reduced to one-third of the amount obtained by extraction with ethanol 90% (v/v) (Fig. 4).


Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties.

Naser B, Bodinet C, Tegtmeier M, Lindequist U - Evid Based Complement Alternat Med (2005)

The solvent for extraction significantly influences the amount of thujone in the extracts of the dried herbal substance Thujae occidentalis herba.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC1062158&req=5

fig4: The solvent for extraction significantly influences the amount of thujone in the extracts of the dried herbal substance Thujae occidentalis herba.
Mentions: A critical factor for Thuja's use as a medicinal herb is its content of essential oil. Indeed, the content of thujone seems to be significantly affected by different extraction procedures. The highest content of essential oil was found in extracts obtained by distillation, whilst percolation with purified water reduced the thujone content in the extract to the lowest level (29). Using purified water as a solvent, an average of 0.6 mg of thujone was extracted from 1 g of drug during percolation (30). In contrast, when 30% (v/v) ethanol was used, 2.8 mg of thujone was extracted from 1 g of Thujae occidentalis herba, and >2.5-fold higher amounts of thujone (7.9 mg) were attained with high ethanol concentration (90% v/v) (30). From the result of 12 batches, the mean value for the thujone content was 1.16 mg/g of herbal substance and the maximum value was 2.95 mg/g, corresponding to 0.30%. Using a special extraction procedure with 30% (v/v) ethanol, the content of thujone in the extract can be reduced to one-third of the amount obtained by extraction with ethanol 90% (v/v) (Fig. 4).

Bottom Line: Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data.This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant.Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations.

View Article: PubMed Central - PubMed

ABSTRACT
Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections.

No MeSH data available.


Related in: MedlinePlus