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Immunity status against poliomyelitis in Germany: determination of cut-off values in International Units.

Diedrich S, Claus H, Schreier E - BMC Infect. Dis. (2002)

Bottom Line: Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively.Overall, this seroprevalence indicates a very high level of immunity of the general population.It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.

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Affiliation: Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany. DiedrichS@rki.de

ABSTRACT

Background: To prevent importations of wild polioviruses into a polio free region a high level of population immunity must be kept. Standard methodology for determination of polio antibodies is a feature aimed at obtaining consistent results. An International Standard Serum for polio antibodies exists, but no protective level in International Units is defined.

Methods: A representative study was carried out in order to determine the serological status against poliomyelitis in Germany (n = 2564, age 18-79 years). Furthermore, sera from persons aged less than 18 years were included (n = 881). Microneutralization test has been used for determination of antibody levels. Results have been expressed in International Units.

Results: The results of this study indicate that the cut-off level for polio antibodies is 0.075 IU/ml for Polio 1, 0.180 IU/ml for Polio 2 and 0.080 IU/ml for Polio 3. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively.

Conclusions: Overall, this seroprevalence indicates a very high level of immunity of the general population. It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.

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Related in: MedlinePlus

Prevalence of antibodies to polio viruses in Germany, n = 3445
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Figure 1: Prevalence of antibodies to polio viruses in Germany, n = 3445

Mentions: Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2% (95% confidence interval CI: 95.5%-96.9%), 96.8% (CI: 96.1%-97.5%) and 89.6% (CI: 88.4%-90.8%) of samples, respectively (Fig. 1). 85% of all tested persons had antibodies against all three virus types. Only 0.3% of tested persons had no detectable antibodies against all polioviruses.


Immunity status against poliomyelitis in Germany: determination of cut-off values in International Units.

Diedrich S, Claus H, Schreier E - BMC Infect. Dis. (2002)

Prevalence of antibodies to polio viruses in Germany, n = 3445
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC101379&req=5

Figure 1: Prevalence of antibodies to polio viruses in Germany, n = 3445
Mentions: Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2% (95% confidence interval CI: 95.5%-96.9%), 96.8% (CI: 96.1%-97.5%) and 89.6% (CI: 88.4%-90.8%) of samples, respectively (Fig. 1). 85% of all tested persons had antibodies against all three virus types. Only 0.3% of tested persons had no detectable antibodies against all polioviruses.

Bottom Line: Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively.Overall, this seroprevalence indicates a very high level of immunity of the general population.It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.

View Article: PubMed Central - HTML - PubMed

Affiliation: Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany. DiedrichS@rki.de

ABSTRACT

Background: To prevent importations of wild polioviruses into a polio free region a high level of population immunity must be kept. Standard methodology for determination of polio antibodies is a feature aimed at obtaining consistent results. An International Standard Serum for polio antibodies exists, but no protective level in International Units is defined.

Methods: A representative study was carried out in order to determine the serological status against poliomyelitis in Germany (n = 2564, age 18-79 years). Furthermore, sera from persons aged less than 18 years were included (n = 881). Microneutralization test has been used for determination of antibody levels. Results have been expressed in International Units.

Results: The results of this study indicate that the cut-off level for polio antibodies is 0.075 IU/ml for Polio 1, 0.180 IU/ml for Polio 2 and 0.080 IU/ml for Polio 3. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively.

Conclusions: Overall, this seroprevalence indicates a very high level of immunity of the general population. It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.

Show MeSH
Related in: MedlinePlus