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Primary CNS Lymphoma

Uyesugi WYU - MedPix (2001)

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Affiliation: Tripler Army Medical Center

ABSTRACT

Primary malignant lymphoma, formerly called reticulum cell sarcoma, histiocytic lymphoma, and microglioma, is a non-hodgkins lymphoma that occurs in the brain in the absence of systemic involvement. These tumors are highly cellular and grow rapidly. Favorite sites include the deeper parts of the frontal and parietal lobes, basal ganglia and hypothalamus. Most occur in patients who are immunosupressed secondary to chemotherapy or acquired immunodeficiency (AIDS) or in organ transplant recipients who are on immunosuppressant drugs. Cerebral lymphomas are very radiosensitive and respond dramatically to steroid therapy. They usually show an excellent initial response to radiation or chemotherapy. The tumor may "melt away" - giving rise to the nickname of "ghost tumors". However, recurrence is very common, and most patients die from this disease. Lymphomas typically appear as homogeneous slightly high signal to isointense masses deep within the brain on T2 weighted images. The observed mild T2 prolongation is probably related to dense cell packing wihtin these tumors, leaving relatively little interstitial space for accumulation of water. They are frequently found in close proximity to the corpus callosum and have a propensity to extend across the corpus callosum into the opposite hemisphere, a feature that mimics gliobalstoma. Multiple lesions are present in as many as 50%. Despite their rapid growth, central necrosis is uncommon. They are associated with only a mild or moderate amount of peritumoral edema. By the time of presentation they can be quite large and yet produce relatively little mass effect, a feature that sets lymphoma apart from glioblastoma and metastases. Intratumoral cysts and hemorrhage are unusual. Most lymphomas show bright homogeneous contrast enhancement.

No MeSH data available.


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Primary CNS Lymphoma

Uyesugi WYU - MedPix (2001)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2792&req=5

View Article: MedPix Image - MedPix Topic

Affiliation: Tripler Army Medical Center

ABSTRACT

Primary malignant lymphoma, formerly called reticulum cell sarcoma, histiocytic lymphoma, and microglioma, is a non-hodgkins lymphoma that occurs in the brain in the absence of systemic involvement. These tumors are highly cellular and grow rapidly. Favorite sites include the deeper parts of the frontal and parietal lobes, basal ganglia and hypothalamus. Most occur in patients who are immunosupressed secondary to chemotherapy or acquired immunodeficiency (AIDS) or in organ transplant recipients who are on immunosuppressant drugs. Cerebral lymphomas are very radiosensitive and respond dramatically to steroid therapy. They usually show an excellent initial response to radiation or chemotherapy. The tumor may "melt away" - giving rise to the nickname of "ghost tumors". However, recurrence is very common, and most patients die from this disease. Lymphomas typically appear as homogeneous slightly high signal to isointense masses deep within the brain on T2 weighted images. The observed mild T2 prolongation is probably related to dense cell packing wihtin these tumors, leaving relatively little interstitial space for accumulation of water. They are frequently found in close proximity to the corpus callosum and have a propensity to extend across the corpus callosum into the opposite hemisphere, a feature that mimics gliobalstoma. Multiple lesions are present in as many as 50%. Despite their rapid growth, central necrosis is uncommon. They are associated with only a mild or moderate amount of peritumoral edema. By the time of presentation they can be quite large and yet produce relatively little mass effect, a feature that sets lymphoma apart from glioblastoma and metastases. Intratumoral cysts and hemorrhage are unusual. Most lymphomas show bright homogeneous contrast enhancement.

No MeSH data available.