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MRS - MR Spectroscopy

Smirniotopoulos, M.D. JGSM - MedPix (1998)

View Article: MedPix Image - MedPix Topic

Affiliation: Uniformed Services University

ABSTRACT

MR Spectroscopy can be obtained from a single volume of tissue - a voxel; or, by a multivoxel technique - where there is a grid of spectra from several adjacent volume regions. Going from left to right in a conventional MRS display, there are several normal and abnormal spectral peaks: • Myoinositol is elevated in mature glial neoplasms • Glutamate reflects excitotoxicity (e.g. seizures) or damage from ongoing infarction. • Choline is associated with cell membrane synthesis and degradation. Choline is usually shorter than Creatine. This peak is increased in neoplasms, but also slightly elevated in reactive processes. • Creatine is a normal "baseline" spectrum, often used as a reference height for comparison. • N-acetyl aspartate (NAA) is unique to the vertebrate nervous system, and relates to healthy neurons. In normal brain this is typically the tallest peak. • Lactate is not normal in brain, and indicates anaerobic glycolysis from ischemia or necrosis in a neoplasm. • Lipids are elevated in some necrotic lesions • Amino acid peaks are associated with tissue breakdown in an abscess • Lysine may be present in Ependymoma (DDx spinal masses) »

No MeSH data available.


Hypothetical MR spectroscopy in a neoplasm.  Hunter's Angle is broken.  The n-acetyl-aspartate peak (NAA) is missing; and, the choline (Cho) peak is greater than creatine (CR).  This suggests an increase in cell synthesis - corresponding to a neoplasm.  Lactate and lipid may also be elevated with tumor necrosis.
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MPX2686_synpic36079: Hypothetical MR spectroscopy in a neoplasm. Hunter's Angle is broken. The n-acetyl-aspartate peak (NAA) is missing; and, the choline (Cho) peak is greater than creatine (CR). This suggests an increase in cell synthesis - corresponding to a neoplasm. Lactate and lipid may also be elevated with tumor necrosis.


MRS - MR Spectroscopy

Smirniotopoulos, M.D. JGSM - MedPix (1998)

Hypothetical MR spectroscopy in a neoplasm.  Hunter's Angle is broken.  The n-acetyl-aspartate peak (NAA) is missing; and, the choline (Cho) peak is greater than creatine (CR).  This suggests an increase in cell synthesis - corresponding to a neoplasm.  Lactate and lipid may also be elevated with tumor necrosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2686&req=5

MPX2686_synpic36079: Hypothetical MR spectroscopy in a neoplasm. Hunter's Angle is broken. The n-acetyl-aspartate peak (NAA) is missing; and, the choline (Cho) peak is greater than creatine (CR). This suggests an increase in cell synthesis - corresponding to a neoplasm. Lactate and lipid may also be elevated with tumor necrosis.

View Article: MedPix Image - MedPix Topic

Affiliation: Uniformed Services University

ABSTRACT

MR Spectroscopy can be obtained from a single volume of tissue - a voxel; or, by a multivoxel technique - where there is a grid of spectra from several adjacent volume regions. Going from left to right in a conventional MRS display, there are several normal and abnormal spectral peaks: • Myoinositol is elevated in mature glial neoplasms • Glutamate reflects excitotoxicity (e.g. seizures) or damage from ongoing infarction. • Choline is associated with cell membrane synthesis and degradation. Choline is usually shorter than Creatine. This peak is increased in neoplasms, but also slightly elevated in reactive processes. • Creatine is a normal "baseline" spectrum, often used as a reference height for comparison. • N-acetyl aspartate (NAA) is unique to the vertebrate nervous system, and relates to healthy neurons. In normal brain this is typically the tallest peak. • Lactate is not normal in brain, and indicates anaerobic glycolysis from ischemia or necrosis in a neoplasm. • Lipids are elevated in some necrotic lesions • Amino acid peaks are associated with tissue breakdown in an abscess • Lysine may be present in Ependymoma (DDx spinal masses) »

No MeSH data available.